Hui Ye Lab@CPU

PI in China Pharmaceutical University. Focus on chemical proteomics, PTM and metabolomics. Interested in probing how metabolites and drugs regulate proteins.

[Jing Yang @Yang_J_lab]

We are very excited to share our new study @nchembio with @KateCarrollLab, expanding the ligandable/druggable space in the cysteine redoxome. This paper represents 6-yr hard works, led by Ling Fu and Youngeun Jung.
https://t.co/Naypgj9nRZ

[Hui Ye Lab@CPU @HuiYeLabCPU1]

Welcome to join us on Aug 10th 2 pm (Beijing time) and follow Prof. Bernhard Kuster to decryt drug MoA using chemoproteomics and phosphoproteomics!@kusterlab

[Jing Yang @Yang_J_lab]

Thrilled to announce that pChem is now online @nchembio. This easy-to-use computational too provides a streamlined pipeline for unbiased performance assessment of chemoproteomic probes. 1/n
https://t.co/7pioGfyZ5r

[Hui Ye Lab@CPU @HuiYeLabCPU1]

Congrats to Erin!!! Great work!!!

[Baker Lab UNC @BakerLabMS]

We are so excited to share our newest manuscript @NatureProtocols! This protocol shows how to use Skyline to evaluate lipidomic data & took 1.5 yrs in review😅(thanks reviewers). It has a 4D lipidomic library & datasets to try. Way to go @KaylieKirkwood!
https://t.co/q6tC5Ma87Y

[Baker Lab UNC @BakerLabMS]

We are so excited to share our newest manuscript @NatureProtocols! This protocol shows how to use Skyline to evaluate lipidomic data & took 1.5 yrs in review😅(thanks reviewers). It has a 4D lipidomic library & datasets to try. Way to go @KaylieKirkwood!
https://t.co/q6tC5Ma87Y

[Ying Ge Research Lab @Ge_Lab_UW]

Register for a great conference (and cool prizes!) here:

https://t.co/Ae8ezYM9ni

[George Caputa @curiousdrgeorge]

The detection of metabolites has come a long way.

This Perspective in @Cell_Metabolism by @kadzuis @yaneslab & @MartinGiera looks back on the history of metabolite identification, current & new tech, and where the field of metabolomics is going

https://t.co/sZi3LNlmUt

[Hui Ye Lab@CPU @HuiYeLabCPU1]

Love the July issue most! coz our work is in it 🥳

[Nature Methods @naturemethods]

Our July issue is live! https://t.co/ohUmEMTXjb

On the cover, microfabricated organoid culture chips enable high-content 3D imaging. Artwork by Diego Pitta de Araujo, representing https://t.co/tAy656isZo from @Viasnofflab @BeghinTeam and colleagues.

[Hui Ye Lab@CPU @HuiYeLabCPU1]

The 2nd CASMS conference goes virtual! Very much looking forward to it! The deadline for abstract submission is 07/29.

[Chinese American Society for Mass Spectrometry @CASMSorg]

Call For Abstract! The 2nd Chinese American Society for Mass Spectrometry Virtual Conference (10/17-10/21, 2022). Submit your abstract by 07/29 to compete for > 20 presentation awards! Presenters will receive complimentary registration! https://t.co/n5gv4I538F

[Hui Ye Lab@CPU @HuiYeLabCPU1]

So glad this event can be attended virtually😁🙆‍♀️

[Lingjun Li @LingjunLi2]

Looking forward to this exciting event!

[Hui Ye Lab@CPU @HuiYeLabCPU1]

@naturemethods @DrArunimaSingh @hecklab Immonium ion is doing its trick again!

[Hui Ye Lab@CPU @HuiYeLabCPU1]

@naturemethods @DrArunimaSingh @HuiYe93121721 @FemalesInMS Thank you for your patience and help when handling our work during the past 9 mon! We are so excited that it is online! This work has received tons of attention in China but most of them can't tweet😀I hope more people will be interested in digging dark matter from the proteome!

[Hui Ye Lab@CPU @HuiYeLabCPU1]

@galliganlab It was not discussed in the section where we demonstrated the regulatory role of Klac on glycolysis because we specifically introduce L-lac to ALDOA rather than D-lac. There was a discussion on these two PTMs, and we feel sorry about cutting it due to word limit during revision.

[Hui Ye Lab@CPU @HuiYeLabCPU1]

@galliganlab Dear Dr. Galligan, we certainly have read your paper on Cell Chem Biol which reports the formation of D-lactylation. It has been cited as ref 19 in the main text.

[Hui Ye Lab@CPU @HuiYeLabCPU1]

Thank Nature Methods and Andy for the great highlight article!

[Nature Methods @naturemethods]

Read the News & Views highlighting this work here: https://t.co/iMZVeZUHQ7

[Hui Ye Lab@CPU @HuiYeLabCPU1]

Congrats to Mike and Meng!

[Lingjun Li @LingjunLi2]

What a fun celebration with @LiResearch group members! Congratulations to Mike and Meng on your well-earned PhDs! We will miss you. Good luck and best wishes for your new positions @GileadSciences and @BrukerMassSpec !

[Hui Ye Lab@CPU @HuiYeLabCPU1]

Thank Lingjun for the 5-year hard-core mass spec traning and continuing support along the way! Hopefully more functional interplay between metabolites and proteins can be discovered with powerful MS techniques😀😀😀

[Lingjun Li @LingjunLi2]

A cyclic immonium ion as diagnostic ion led to proteome wide discovery of lysine lactylation. Congratulations to former @LiResearch alum Prof. @HuiYe93121721 and her colleagues @HuiYeLabCPU1 on this great work published in @naturemethods !#PTM

[Hui Ye Lab@CPU @HuiYeLabCPU1]

@Gaoyuan_Lu Thank you for helping us to increase our work's visibility! We hope that more researchers are willling to dig deep to mine the dark matter in the human proteome!

[Hui Ye Lab@CPU @HuiYeLabCPU1]

Thank Nature Methods for publishing our work! With the cycIm ion, we found that lactylation is a widespread and functional PTM in human. Proteomics, molecular biology and chem biology tools are jointly used. It was a team effort! Thank @LingjunLi2 @GrahamDelafield for support!

[Nature Methods @naturemethods]

Hui Ye and colleagues report the cyclic immonium ion as a diagnostic fragment ion for lysine lactylation. They analyzed various enriched and unenriched proteome databases to demonstrate prevalence of this PTM beyond histones. @HuiYe93121721 @FemalesInMS
https://t.co/2lTqwYfh05