HullemanLab

A vision research lab leveraging chemical biology, biochemistry, drug discovery, and gene therapy to develop unique approaches for retinal diseases.

[HullemanLab @HullemanLab]

After a year-long hiatus from X, it is nice to see a shout-out from @NEIDirector Michael Chiang on our #Nlrp3 paper just before ringing in the New Year! #NIHfunded #UMNproud

Cell Death and Disease article link: https://t.co/K4KmTGnTnL

[Michael F. Chiang, MD @NEIDirector]

#NIHfunded work shows targeting the inflammatory sensor Nlrp3 reduced early #AMD-like pathology in preclinical models, underscoring inflammation as a therapeutic target.
@Umnmedschool @HullemanLab @UTSWMedCenter #VisionResearch
@cddpress paper: https://t.co/S9gk0q7xX0

[HullemanLab @HullemanLab]

#HappyHolidays from the Hulleman Lab! Our Texas-born #Christmas cactus has been working overtime this year!

[HullemanLab @HullemanLab]

Cool to see our work highlighted in the @promega Connections blog. Thanks to Jordan Villanueva for the write up! Check it out below.

https://t.co/eenjvr5FV0

[HullemanLab @HullemanLab]

Congrats to Nathan Johnson, Ph.D. for securing a VitreoRetinal Surgery Foundation (VRSF) Fellowship to extend his time in the lab!

[HullemanLab @HullemanLab]

Looking forward to presenting @UciCtvr this Friday! Hope you can attend, see announcement below.

[Brunson Center for Translational Vision Research @UciCtvr]

Small molecule remodeling of the ECM prevents AMD-like pathology

More details and link to join here: https://t.co/Y9rpXIf8Oy

[HullemanLab @HullemanLab]

Welcome to @MPaT_PHCL_UMN rotation students Jillian VanTreeck and Julian Yang. Two full weeks in and already some successful HiBiT edits. It’s great to have their enthusiasm in the lab! #visionscience #ophthalmology

[HullemanLab @HullemanLab]

Proud of our first yellow flame plasmid in @Addgene! Request yours while supplies last…
https://t.co/YDV2ZQNrHA

[HullemanLab @HullemanLab]

Don’t hit snooze after your parrilla-induced siesta today!

Be sure to stop by our #ISER2024 session on small molecule therapies for retinal diseases - Quebracho B 5th Floor starting at 3:30PM. @iserworld

[HullemanLab @HullemanLab]

What a difference a day makes - clearly fall in MN, lovely spring (almost summer) weather in Buenos Aires. #ISER2024 has started off with a strong program today. @iserworld

[HullemanLab @HullemanLab]

Great to see that our #AMD-related work was recognized by @NEIDirector!

Beautiful photo credit: @StefPhDaniel and @pravz2505

[Michael F. Chiang, MD @NEIDirector]

From @UMNews: researchers led by John Hulleman discovered a new pathway to prevent #AMD (mouse model) by reducing the production of glycoprotein fibulin-3.

#NEIfunded @umnmedschool @HullemanLab

@JCI_insight paper: https://t.co/0Ft7Bn47Qf

[UMN Medical School @umnmedschool]

Exciting news: U of M researchers have discovered a potential new pathway to prevent age-related macular degeneration.

Read more from John Hulleman, PhD ➡️: https://t.co/WYcJ1mSC7y.

#MacularDegeneration | #AMD

[HullemanLab @HullemanLab]

#ISER2024 is 2 mo away! Mark your calendars - Yuanyuan Chen @UPMC and I are hosting a session on small molecule therapies for retinal degeneration. Talks by @StefPhDaniel, Liyun Zhang @HopkinsMedicine, Tim Corson @UofTPharmacy, Marco Bassetto @UciCtvr, and yours truly. @iserworld

[HullemanLab @HullemanLab]

Very excited to share our recent work just published in @JCI_Insight. Low level #GSK3 inhibition via CHIR99021 remodels the #ECM and prevents BLamDs in an early-onset #AMD mouse model. Congrats to Sophie DiCesare on a great paper! @UMNews

https://t.co/VCYDSdu2XW

[HullemanLab @HullemanLab]

After dedicating 2+ yrs to the Lab, quantifying ~35,000 microns of Bruch’s memb./basal laminar deposits in TEM images, Antonio Ortega is now a Vivien Thomas PhD Scholar @HopkinsMedicine. Thankful for the opportunity to teach and learn from Ant and excited for his next chapter!

[HullemanLab @HullemanLab]

In our latest work, we show that fibulin-3 cysteine mutations present in the human population can severely compromise secretion, affect #MMP2 activity, and trigger #ERstress with implications for human #ECM diseases. @biorxivpreprint @ClinGenResource
https://t.co/XtDE7G9tle

[HullemanLab @HullemanLab]

Happy to announce that we have received a two-year Regenerative Medicine Minnesota grant to develop next-gen tools to better study proteins implicated in age-related macular degeneration (#AMD). @UMNews @UMNmedschool #RegenMedMN

[HullemanLab @HullemanLab]

Congrats to @StefPhDaniel for receiving a travel grant to attend the #ISER2024 meeting in Argentina. Also, welcome to medical student Nathan Johnson, who secured a summer research fellowship from the University of Minnesota-Duluth. #visionresearch #ophthalmology @iserworld

[HullemanLab @HullemanLab]

It's hard to get 7 people in a photobooth. n = 4 for a partially successful whole lab picture. Happy Birthday Antonio!

[HullemanLab @HullemanLab]

Over the past month the Hulleman Lab has grown substantially. It's great to welcome Emily Baker, Anna Roovers, Pravallika Kambhampati, and Harkamal Kaur to the team! #visionscience #ophthalmology

[HullemanLab @HullemanLab]

An amazing resource @UMNresearch is the access to human donor eyes. Since ~2500 eyes are processed annually by @LionsGiftSight, we took a cool Lab Field Trip to learn about the process and watch a human globe dissection by the talented Sung Lee. #AMD #RPE