Institute of Developmental Genetics

Official account of the Institute of Developmental Genetics at the Helmholtz Zentrum München - Impressum

[Institute of Developmental Genetics @IDG_Wurst]

We thank all our collaborators for this fantastic work on molecular mechanisms in early #Parkinson´s Disease. Not possible without you!!!!! @NatureComms : https://t.co/CBiNkXJKue @LickertHeiko @fabian_theis @DZNE_en @UniFAU @TueNeuroCampus @SyNergy_Cluster

[PioneerCampus @HelmholtzMunich @PioneerCampus]

📣Job ALERT📣 Science Grant & Project Manager🎇 @PioneerCampus @HelmholtzMunich https://t.co/Kpx77AjKUX
✅committed ✅capable ✅coordinated - to support our #innovative #international #inclusive PI's shaping the future of biomedicine/heath👇
https://t.co/PkPtDMGlCc @helmholtz_en

[IMPC @impc]

Happy #RareDiseaseDay! 💚
@impc we work to produce a genome-wide resource of mutant mouse lines to model human biology and disease, to enable diagnosis and therapeutic discovery, including #rarediseases

[Patrik Brundin MD PhD @BrundinPatrik]

Exiting times ahead!
First patient receives milestone #stem cell-based #transplant for #Parkinson Disease at Lund University, Sweden. https://t.co/ilvhNPVdJy

[Gene Therapy @GeneTherapy_SN]

Online now, Huazhong University researchers use #CRISPR-based homology-directed repair of the MYBPC3 gene to rescue #HypertrophicCardiomyopathy phenotypes in an animal model. Read #GTArticle here now➡️https://t.co/OAC4lssbhH
📷: ©iStock

[ESC & iPSC News @ESC_iPSC_News]

🧪 Dr. Matthias Mann (@labs_mann) and collaborators generated a comprehensive atlas of #proteomes, #chromatomes, and chromatin affinities for the ground, formative, and primed #pluripotency states. @MPI_Biochem @UCPH_CPR @NAR_Open

🔗 https://t.co/SyqN8MdlfT

[Helmholtz Munich | @HelmholtzMunich @HelmholtzMunich]

Tomorrow, the @DigiMedBayern symposium on Big Data and AI takes place with a talk from #HelmholtzMunich researcher Annette Peters and an exciting session on infrastructure for big data. Program:https://t.co/CAQUdNghPB More about our part👉https://t.co/JAw8g0Y0ec @EPI_Helmholtz

[Heiko Lickert @LickertHeiko]

Beautiful example of dynamic RTK signaling - shows you really should plan your experiments well to understand what happens😲

[The Science of Parkinson's @ScienceofPD]

Using primary mouse cells, @smoburke & @LouisTrudeau find that certain types of neurons (that are differential more vulnerable in #Parkinsons) are endowed with larger axonal domains, which are more complex & have more axonal varicosities
https://t.co/PtCIAsfum5

[The Science of Parkinson's @ScienceofPD]

The definitive guide to current research on the neuroprotective effects of glucagon-like peptide 1 (GLP-1) in #Alzheimers & #Parkinsons; "Novel dual agonists have been developed to cross the BBB at an enhanced rate, showing superior effects"
https://t.co/ne0cEsgdCv

[The Science of Parkinson's @ScienceofPD]

Feel the RAGE:
New research reportst that #Parkinsons-associated α-Synuclein is a ligand of receptor for advanced glycation end products (RAGE), which mediates the binding of α-syn amyloid fibrils to microglia; RAGE inhibitor FPS-ZM1 mitigated neuroinflam.
https://t.co/RwBG579cd7

[Institute of Developmental Genetics @IDG_Wurst]

Maybe help for a percentage of PD patients available?

[The Science of Parkinson's @ScienceofPD]

Researchers significantly reduced #Parkinsons-associated α-synuclein (oligomer) accumulation in the mouse striatum through long-term LRRK2 inhibition using GNE-7915 (specific brain-penetrant LRRK2 inhibitor) without causing adverse peripheral effects
https://t.co/RmdMHZZcB9

[The Science of Parkinson's @ScienceofPD]

Ooooh, look at that:
@MicheleTagliati & colleagues have made a preprint of results of the Phase II, randomized, double-blinded, placebo-controlled clinical trial of Liraglutide in #Parkinsons available - Study funded by @CureParkinsonsT
https://t.co/2F4XiKasdp

[Benjamin Stecher @Neuronologist1]

Here is a relatively simple question that there seems to be no answer to: How many different symptoms are associated with the clinical label we call #Parkinsons Diseases?

[Gene Therapy @GeneTherapy_SN]

Trending now is a review by Alexa Rabeling and Mubeen Goolam @UCT_news discussing the applications and limitations of #cerebralorganoids in #AutismSpectrumDisorder research and drug development. Join our #GTReaders now➡️https://t.co/g5sUIzSQNn

📸: @harvardstemcell/@MITChemE

[INACTIVE ACCOUNT Lars Dittrich @dittrich_lars]

Wer kann meinem Sohn diese Frage beantworten: Wenn man den Kopf unter Wasser hält, nennt man das tauchen. Wie nennt man es, wenn ein Fisch so lange er kann den Kopf über Wasser hält?

[Helmholtz Munich | @HelmholtzMunich @HelmholtzMunich]

In der @ARDalpha Doku „𝐃𝐢𝐞 𝐌𝐞𝐝𝐢𝐳𝐢𝐧 𝐯𝐨𝐧 𝐌𝐨𝐫𝐠𝐞𝐧“ spricht @KSchwanke von Min 35:54 – 40:11 mit @LickertHeiko über die Rolle der #Bauchspeicheldrüse und #Insulin bei der Behandlung von #Diabetes.
📺https://t.co/T0qff2au9s
@helmholtz_diabc

[The Science of Parkinson's @ScienceofPD]

New research from @christina_neuro @LabGandhi & colleagues provides an in-depth regional profile of the proteome at different stages of #Parkinsons; Highlights mitochondrial dysfunction as detectable prior to neuronal loss & alpha-synuclein deposition
https://t.co/6jAg9XkEzs

[Trends in Neurosciences @TrendsNeuro]

'How the immune system shapes neurodegenerative diseases'

@TrendsNeuro Review by Hannah Mason & Dorian McGavern

https://t.co/mQZ2twPRuF

[The Science of Parkinson's @ScienceofPD]

Researchers examine the distribution of α-synuclein oligomers in formalin-fixed paraffin-embedded brain samples from patients with #Parkinsons; Distribution of oligomers = more widespread than that of Lewy-related pathology
https://t.co/IlwZbDD01p

[Organoid News @organoidscience]

Congrats to Dr. @HansClevers on his new @CellStemCell paper! 🎉

It presents an optimized #protocol for culturing human small intestinal #organoids, and uses them to reveal the interleukin-22-dependency of paneth cell formation.

Learn more: https://t.co/cpETeN3dQ3