IUSM Dept of Biochemistry and Molecular Biology

Department of Biochemistry and Molecular Biology at Indiana University School of Medicine. @IUMedSchool

[IUSM Dept of Biochemistry and Molecular Biology @IUSM_Biochem]

This Lectureship is given in honor of Dr. Peter Roach, who made exceptional contributions to the field of Glycogen Metabolism and Lafora Disease during his 40+ years at IUSM.
Join us at 3pm, in MS 326 to celebrate Dr. Roach, and hear the extraordinary reseasrch led by Dr. Bass.

[IUSM Dept of Biochemistry and Molecular Biology @IUSM_Biochem]

Join us on June 9th for the Peter J Roach Lectureship. This year, we are thrilled to have Dr. Joseph T Bass, Director of the Center for Diabetes and Metabolism at Northwestern University present his work "Leveraging Biological Timing for RNA-Based Obesity Therapeutics".

[IUSM Dept of Biochemistry and Molecular Biology @IUSM_Biochem]

Join today for the Thesis Defense of Michael Liesen, PhD Candidate in the labof Dr. Jonah Vilseck! 1:30PM in MS 326!

[IUSM Dept of Biochemistry and Molecular Biology @IUSM_Biochem]

Congratulations to Dr. Ron Wek, who was named a Fellow of the American Society for Biochemistry and Molecular Biology!

https://t.co/lVhlng8Ikb

[IUSM Dept of Biochemistry and Molecular Biology @IUSM_Biochem]

Today we welcome Dr. Wei Qiu to our BMBP seminar! Dr. Qiu, Professor of Cancer Biology and Surgical Research at Loyola University, will present on “The role of ABL Kinases in liver
Pathogenesis”. 4pm, MS B26, Cookies and Coffee Provided

[IUSM Dept of Biochemistry and Molecular Biology @IUSM_Biochem]

Join us for our student-invited speaker Dr. Vincent Tagliabracci, an HHMI investigator from UT Southwestern. Dr. Tagliabracci will speak on "Expanding the Kinome" today at 4pm, MS B26. Cookies and coffee provided!

[IUSM Dept of Biochemistry and Molecular Biology @IUSM_Biochem]

BMBP seminar welcomes Dr. Anish Thomas today from the NCI! Dr. Thomas will talk about his work "Decoding tumor heterogeneity and plasticity: from patients to mechanisms". MS B26, 4pm, Cookies and Coffee provided!

[IUSM Dept of Biochemistry and Molecular Biology @IUSM_Biochem]

Today for Biochemistry, Molecular Biology and Pharmacology seminar we welcome Dr. Patrick Sheets, Associate Professor of Pharmacology and Toxicology. He will speak on Reverse engineering the organization of supraspinal pain circuits in mice'. 4pm, MS B26, with Cookies and Coffee!

[IUSM Dept of Biochemistry and Molecular Biology @IUSM_Biochem]

Join us today for Biochemistry Seminar! We look forward to hearing from Dr. Jennifer Heemstra, Chair of the Department of Chemsitry at the University of Washington. Dr. Heemstra will speak on “A Chemical Biology Toolbox for Probing A-to-I RNA Editing". 4pm, MS B26.

[IUSM Dept of Biochemistry and Molecular Biology @IUSM_Biochem]

2/2: The research was led by Ricardo Cordova, a recent graduate of the Biochemstry Department, and investigators Dr. Kirk Staschke and Ron Wek, among others. @kirkstaschke

[IUSM Dept of Biochemistry and Molecular Biology @IUSM_Biochem]

New paper alert! https://t.co/1cgk7Gz72t

1/2: This exciting work recently published in Cancer Research uncovers how caloric restriction impacts androgen receptor translation and boosts prostate tumor sensitivity to Enzalutamide.

[IUSM Dept of Biochemistry and Molecular Biology @IUSM_Biochem]

Join us today for Biochemistry seminar! We welcome Dr. Jacob Durrant from the University of Pittsburgh, speaking on "From Molecules to Medicines: A Wed-Centric Approach to Small- Molecule Ligand Identification and Optimization". 4pm, MS B26

[IUSM Dept of Biochemistry and Molecular Biology @IUSM_Biochem]

Noah Sommers, PhD student in the Biochemistry Department, presented his research on GCN2 in prostate cancer progression at the American Association for Cancer Research!

[IUSM Dept of Biochemistry and Molecular Biology @IUSM_Biochem]

We are trhilled to welcome Dr. Angela Gronenboen, UPMC Rosalind Franklin Professor, Chair and Distinguished Professor of Structural Biology at the University of Pittsburgh School of Medicine. She will speak on "The awesome power of fluorine NMR-from drugs to cells". 3/3 4pm MSB26

[IUSM Dept of Biochemistry and Molecular Biology @IUSM_Biochem]

Join us today for Biochem seminar! We are thrilled to welcome Dr. Richard Carpenter from Indiana University Bloomington, who will speak on his research studying "Emerging Roles for HSF1 in Breast Cancer". 4pm, MS B26, Coffee and Cookies Provided!

[IUSM Dept of Biochemistry and Molecular Biology @IUSM_Biochem]

2/2: Human Asparagine Synthetase (ASNS), an amidotransferase essential for asparagine biosynthesis, plays a role in cancer progression and neural development. This study, leveraging Glacios Cryo-EM at IUSM and MD simulations, uncovered a key residue critical to ASNS's mechanism.

[IUSM Dept of Biochemistry and Molecular Biology @IUSM_Biochem]

1/2: Publication Announcement! In a new manuscript published in Nature Communications, Dr. Yuichiro Takagi @LabTakagi and collaborators used Cryo-EM to reveal the catalytic mechanism of Human Asparagine Synthetase (ASNS): https://t.co/yzNS9DhVWr

[IUSM Dept of Biochemistry and Molecular Biology @IUSM_Biochem]

4pm, MS B26, cookies and coffee provided.

[IUSM Dept of Biochemistry and Molecular Biology @IUSM_Biochem]

Join us today for the Student-Invited Speaker! Dr. Julio Aguirre-Ghiso, Ph.D., Professor of Cell Biology, Oncology and Medicine at Albert Einstein College of Medicine, will present research on Early Dissemination and Cancer Cell Dormancy: Rethinking Metastasis Biology

[IUSM Dept of Biochemistry and Molecular Biology @IUSM_Biochem]

Coordination between ISR and p53 may be crucial for prostate cancer cells to survive chemotherapies, thus targeting the ISR may promote cell death of p53-negative tumors. Congratulations to Dr. Cordova, Noah Sommers, Drs. Staschke and Wek, and all the co-authors who contributed!

[IUSM Dept of Biochemistry and Molecular Biology @IUSM_Biochem]

New publication from the laboratories of Drs.Kirk Staschke and Ron Wek, featured on the cover of Science Signaling! https://t.co/PFcqp4i6AO

[IUSM Dept of Biochemistry and Molecular Biology @IUSM_Biochem]

In this work, Dr. Cordova and colleagues showed that activation of the ISR, particularly through the kinase GCN2, is required for prostate cancer cell survival and tumor growth. Inhibition of GCN2 limited cell growth, but also induced tumor senescence through p53 signaling.