Sabyasachi Senapati

Assistant Professor, geneticist, public health researcher, free and rational thinker, critics, optimist, tweets are personal

[Sabyasachi Senapati @Indian_Sena]

Is this farmhouse from you @dominos_india ?
Pathetic.

[Journal of Clinical Investigation @jclinicalinvest]

The complement system in intestinal inflammation and cancer

As part of JCI’s Review series on complement biology and therapeutics, Carsten Krieg & Silvia Guglietta @GugliettaLab @MedUnivSC et al. highlight the complement system in the GI tract under homeostasis, #inflammation, and during tumor development, progression, and treatment: https://t.co/Kks9gOOMhP

[Aging Science News @AgingBiology]

An inheritance of long life
https://t.co/Ir5WTvUW9U

[Nature Reviews Gastroenterology & Hepatology @NatRevGastroHep]

New online! Defining the mucosal ecosystem: epithelial–mesenchymal interdependence in gastrointestinal health and disease https://t.co/NMxUw2CMDi

[Cell @CellCellPress]

Now online! IL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity https://t.co/FOTlaFaXEd

[Waggoner Lab @LabWaggoner]

IL-25-induced memory ILC2 enforce mucosal immunity @CellCellPress
https://t.co/end16nJmCH

[nature @Nature]

Nature research paper: Ancient DNA connects large-scale migration with the spread of Slavs

https://t.co/nGtgckH78C

[European Society of Human Genetics (ESHG) @eshgsociety]

🧬Multiplexed Assays of Variant Effect (MAVEs) generate functional data for thousands of variants in a single experiment, accelerating VUS reclassification and improving patient care.
#MAVEs #Genomics

Explore the latest advances in MAVE technologies:
https://t.co/2RlfE6aKEf

[Nature Rev Immunol @NatRevImmunol]

Clock genes keep intestinal ILC3s ticking https://t.co/A1tQRi5Guk

[Marios Georgakis @MariosGeorgakis]

GWASs have revealed thousands of disease-associated variants.

To translate them to therapies we need to know how they act. Historically we linked variants to molecular traits (eQTLs, pQTLs...) in human tissue.

Now it’s increasingly feasible to test them in iPSC-derived cells👇

[Eric Topol @EricTopol]

Your DNA sequence reveals a rare mutation. Will you get the disease, i.e. penetrance? A new study using machine learning predicts this across 10 common diseases, 1,600 genomic variants @IcahnMountSinai @IcahnInstitute @ScienceMagazine https://t.co/FXU8PN2vgp

[Nature Reviews Gastroenterology & Hepatology @NatRevGastroHep]

Our SEPTEMBER ISSUE is live! CRC health disparities, gut microbiome in MASLD, intestinal pH, oesophagus immunology, and much more!

https://t.co/oJ1pn7XNeW

[Trends in Immunology @TrendsImmuno]

Gut microbiota-specific T cell subset drives CNS inflammation https://t.co/Yxq6RMV1Lc #immunology

[Organoid News @organoidscience]

🧫 Researchers at @UWMadison introduced a method of co-culturing adult feline small intestinal organoids with growth-inhibited human foreskin fibroblast feeder cells to enhance organoid proliferation and survival.

@mSphereJ | https://t.co/OevDcGWS0N

[Waggoner Lab @LabWaggoner]

Stromal cell–derived chemokines modulate immune cells in inflammation: New findings and future perspectives @J_Immunol
https://t.co/Y0bChiuejD

[Onkar Tiwari @tiwarionkar]

50,000 years of evolutionary history of India: Impact on health and disease variation: Cell https://t.co/70tTcI5kIk

[Eric Topol @EricTopol]

How gut inflammation can induce brain inflammation
https://t.co/hoAAF6Boyb @Nature

[Cell Press @CellPressNews]

Piezo1 regulates colon stem cells to maintain epithelial homeostasis through SCD1-Wnt-β-catenin and programming fatty acid metabolism. Check out the full study by @2024_HUST Jun Song & colleagues in @CellReports #ISSCR2025 https://t.co/KyL0eCozAq

[Eric Topol @EricTopol]

The unintended consequences of a gut microbiome transplant
https://t.co/oRTMscdrPa

[Nature Reviews Genetics @NatureRevGenet]

New online! Genomics of host–microbiome interactions in humans https://t.co/KeaLyul1k2