GugliettaLab

We are a mucosal immunology lab with expertise in colon cancer, inflammatory bowel disease, microbiome and neuroinflammation.

[GugliettaLab @GugliettaLab]

We are hiring postdoctoral fellows!!! If you are interested in microbiome, colon cancer and immune responses check this out:
https://t.co/GTiYW6IP20

[GugliettaLab @GugliettaLab]

Colorectal cancer is the deadliest cancer for people under 50 #ColorectalCancerAwarenessMonth

[Medical University of South Carolina (MUSC) @MedUnivSC]

Repeated concussions can change the brain over time.

New research from MUSC shows that immune activity may play a major role in long term damage after mild traumatic brain injuries.

Find out more: https://t.co/FvAD24Z7FG

#ChangingWhatsPossible

[Signal Transduction and Targeted Therapy (STTT) @sigtrans_sttt]

#RepeatedMildClosedHeadInjury activates complement-driven neuroimmune responses, induces #microglial dysfunction and #neurodegenerative pathways, and post-injury #ComplementInhibition can reverse these effects. @GugliettaLab @MedUnivSC

#OpenAccess in #STTT: https://t.co/lB3rZKpEo3

[Khalil Mallah @KhalilMallahPhD]

(2/2) Also, none of this work could have been possible without Dr. Silvia Guglietta (@GugliettaLab), Dr. Stephen Tomlinson, and all the contributing authors. @MUSChealth

[Khalil Mallah @KhalilMallahPhD]

🔥📢BIG NEWS!
(1/2) I'm excited to share our accepted paper in Nature's Signal Transduction and Targeted Therapy (@sigtrans_sttt) showing a role for complement in repetitive closed head injury. Many thanks to @ResearchMUSC @DeptVetAffairs @NIH @biaamerica
https://t.co/yFIWILpion

[Carsten Krieg @CarstenKriegPhD]

🚨Our team @GugliettaLab @KhalilMallahPhD just published in Signal Transduction & Targeted Therapy: 10.1038/s41392-025-02466-7. Repetitive mild head injury activates brain’s complement system—driving inflammation&memory loss. Complement blockage protects. @MedUnivSC @ResearchMUSC

[GugliettaLab @GugliettaLab]

We performed a multi-omic characterization of the immune landscape in our new model of repetitive traumatic brain injury and identified the mechanisms associated with the protective role of complement inhibition. Great teamwork @GugliettaLab @KhalilMallahPhD @CarstenKriegPhD

[GugliettaLab @GugliettaLab]

4 years in the making and it is finally out in Signal transduction and targeted therapy!!!! https://t.co/lTIe8tZIV9 @ResearchMUSC @MedUnivSC #braininjury #TBI #Immunology #complement

[GugliettaLab @GugliettaLab]

@humam_kadara @Cancer_Cell @IamLinghua Congratulations! Looking forward to reading it

[GugliettaLab @GugliettaLab]

Happy to share that our article on the role of the complement system in intestinal inflammation and colon cancer is now published in @jclinicalinvest. Great team work @CarstenKriegPhD and @GugliettaLab

[Journal of Clinical Investigation @jclinicalinvest]

The complement system in intestinal inflammation and cancer

As part of JCI’s Review series on complement biology and therapeutics, Carsten Krieg & Silvia Guglietta @GugliettaLab @MedUnivSC et al. highlight the complement system in the GI tract under homeostasis, #inflammation, and during tumor development, progression, and treatment: https://t.co/Kks9gOOMhP

[GugliettaLab @GugliettaLab]

@jasonlukemd @StrandTx Congrats Jason and best of luck with your new role!

[GugliettaLab @GugliettaLab]

@westboundsigned @SDSU Congrats Elena! Exciting news

[GugliettaLab @GugliettaLab]

@humam_kadara @MDAndersonNews Congrats Humam!

[GugliettaLab @GugliettaLab]

@SGrivennikov I changed the title for my resubmission. The grant was funded. I would say that changing the title in a resubmission is not an issue.

[MUSC Hollings Cancer Center @muschollings]

This week on Health Focus, Hollings researcher Dr. Silvia Guglietta talks about her work on immunotherapy in colon cancer. Listen on your SC Public Radio station, or check out the website! https://t.co/y5XWeTeT1n

[GugliettaLab @GugliettaLab]

JCI - Complement-producing maternal microchimeric cells override infection susceptibility in complement-deficient murine offspring https://t.co/mKXF3444g6

[GugliettaLab @GugliettaLab]

Cool work from ⁦@IlievLab⁩ and collaborators: Fungal symbiont transmitted by free-living mice promotes type 2 immunity | Nature https://t.co/uATs5sEGxR

[The American Association of Immunologists (AAI) @ImmunologyAAI]

Have you applied for your IMMUNOLOGY2025™️ travel award? Boost your professional development in May! Whether you're with a Laboratory, #Undergrad, #EarlyCareer - apply today: https://t.co/VMuSxf4fJ2. #AAI2025 #IMMUNOLOGY2025

[GugliettaLab @GugliettaLab]

Complement factor H is an ICOS ligand modulating Tregs in the glioma microenvironment | Cancer Immunology Research | American Association for Cancer Research https://t.co/UqKbWRmQIk

[Mark R@markrobinsonca@{genomic.social,bsky.social} @markrobinsonca]

Interested in benchmarking computational methods in computational biology, generally?

Save the date, submit an abstract, join us next March in Ascona!

Conference website:
https://t.co/wBqBh5yFj4

Please retweet and/or tell your colleagues!