Maria Ioannou

Cell Biologist, Neuroscientist, and Assistant Professor at the University of Alberta

[Journal of Cell Biology @JCellBiol]

Layla M. Nassar and Shawn M. Ferguson @YaleMed discuss Kim et al.’s new study (https://t.co/bUPyliH4x1) showing that TMEM63A protects #lysosomes from rupture by acting as a pressure relief valve when membrane tension rises. https://t.co/9O0NClJjGi

[Maria Ioannou @IoannouLab]

Julie's paper is out!!! Check out how PD mutations in GBA1 and LRRK2 drive the spread of alpha-synuclein through ectosomes!

[Julie Jacquemyn @JacquemynJulie]

So excited to share our work on Glucosylceramide-induced ectosomes propagate pathogenic alpha-synuclein in Parkinson’s disease, now out @ Nature Cell Biology!

@NaturePortfolio

https://t.co/qxy1dOAOtc

[Maria Ioannou @IoannouLab]

Excited to share our new study on ApoE is out!

[Neuron @NeuroCellPress]

Online now: Protective ApoE variants support neuronal function by effluxing oxidized phospholipids https://t.co/r3ZgnuT4Ug

[J Cell Science @J_Cell_Sci]

Luis Fernando Rubio-Atonal, Maria Ioannou @IoannouLab and colleagues @UAlberta @NMHI_UofA find that glutamate decreases oxidative stress and lipid droplet formation in astrocytes.
Highlight: https://t.co/HXDYkFV2I2
Article: https://t.co/5HeoLnHxCM

[Sarah Cohen @cohenlaboratory]

Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations @ShanRhoads and team! 🎉https://t.co/BPxKlbU6Ou

[Gilles Gouspillou @GGouspillou]

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox | Science https://t.co/Ti6n6c3fp7

[Maria Ioannou @IoannouLab]

Thanks to @isharalhan_ @FemkeF @_jesse_jackson @alyy_dodo

[Maria Ioannou @IoannouLab]

Our new preprint describing the role of ApoE2 and ApoE3-christchurch in protecting neurons from lipid peroxidation is out.

https://t.co/SLO2ejzO1Z

[Julie Jacquemyn @JacquemynJulie]

https://t.co/BtJbW2B0ds

[Julie Jacquemyn @JacquemynJulie]

Thrilled to preprint my postdoc work in the @IoannouLab ! 🚀 Using live-cell and two-photon imaging, we reveal that Parkinson’s-linked glucosylceramide changes drive the formation and shedding of ectosomes, fueling α-synuclein spread. This pathway has broad implication in PD.

[James Olzmann @OlzmannLab]

Please RT and help us get the word out. Scott Dixon @sjd956 and I are co-organizing the first @FASEBorg #Ferroptosis conference this summer! Awesome line up of speakers and room for additional short talks! Save the date & come join us July 27 - 31, 2025! 🤩https://t.co/VlV9L3kxx1

[Elizabeth Rideout (@ejrideout.bsky.social) @EJRideout]

Very proud of our paper with @AlquierThierry lab exploring the regulation and function of neuronal lipid droplets under basal conditions. In short, neuronal lipid droplets support the function of hunger-activated neurons to maintain energy homeostasis in 🪰&🐁/1

[Nature Neuroscience @NatureNeuro]

Tau is required for glial lipid droplet formation and resistance to neuronal oxidative stress

https://t.co/5U23N6Vfqq

[CAN ACN @CAN_ACN]

Brain Star Award winner feature: Isha Ralhan | University of Alberta - How neurons protect themselves from lipids damaged by oxidative stress https://t.co/af64Ciy1pv Paper in J Cell Biology https://t.co/I0hDRkXSPV @CIHR_INMHA @UAlberta

[Maria Ioannou @IoannouLab]

Excited to see the much anticipated Neurolipid Atlas has gone live! Congrats to @rikvanderkant and @MartinGiera. Check it out https://t.co/S7ZsAQtyvk

[Maria Ioannou @IoannouLab]

@profLemieux Does anyone know if international trainees will be eligible for these awards now?

[Martin Munz @MartinMunz2]

@RockyMtnBrain @ed_ruthazer @IOB_Roska Thank you! I am very excited to start in the Physiology department @UAlberta . We have open positions for PhD students and postdocs. If you are interested, check out our lab website and send me an email! https://t.co/n7OoclumrV

[Zhe Wang @ZheWang_NCB]

📢Latest Review @NatureCellBio:"A guideline on the molecular ecosystem regulating #ferroptosis" by Dai, @bstockwell, Kroemer, Tang and colleagues.

Check it out and stay tuned for more exciting content on cell death from @NatureCellBio !

https://t.co/0IXpKoJ1qA

[Maria Ioannou @IoannouLab]

Check out our new opinion piece by @JacquemynJulie and @isharalhan_

[Trends Cell Biology @TrendsCellBio]

Driving factors of neuronal ferroptosis https://t.co/7QIFYgkN7Q

[Journal of Cell Biology @JCellBiol]

The E4 variant of APOE is the strongest genetic risk factor for late-onset #Alzheimers. @ia_windham et al @cohenlaboratory find that APOE can traffic to the surface of #LipidDroplets in astrocytes. APOE4 on LDs causes defects in LD composition & morphology https://t.co/wAQpRNtVqw