Isabella Daza

[Cristina Macía @reumacia]

Nueva nomenclatura para los anticuerpos anti-Ro 🧬
Consenso internacional 🗺️ propone estandarizar su denominación
🔹 anti-Ro60 → anti-TROVE2/Ro60
🔹 anti-Ro52 → anti-TRIM21/Ro52
Acceso abierto 🔑 https://t.co/rCT3QiJYYR

[Dr.Mukesh , MD , DM @dr_immuno29]

🩸 Nailfold Capillaroscopy — Dr. Tracy Frech | #ACR25 #ACRambassador

🔹 Raynaud’s = gateway symptom — every CTD eval must include nailfold check
🔹 Device selection: cost 💰, clarity 📸, portability 🖐, automation 🤖 — choose practical
🔹 Report essentials: capillary density (<7/mm), giant loops (>50μm), shape loss, microhemorrhage
🔹 Scleroderma pattern: ↓density + enlarged/abnormal loops + hemorrhages
🔹 Dermatoscope = screening tool (limited in dark skin & late SSc changes)
🔹 AI-based smartphone models show promise for early SSc pattern detection
🔹 Formal training improves accuracy — EULAR certification also helps billing (CPT 93922)
🔹 Combine ASRAP + Capillaroscopy → rapid, multidimensional RP assessment

#Raynauds #Scleroderma #Capillaroscopy #RheumTwitter #ACR25 #Microvasculature

[Dr.Mukesh , MD , DM @dr_immuno29]

ACR Convergence 2025 | Inflammatory Brain Disease for the Clinical Rheumatologist

👨‍⚕️ Eyal Muscal, MD – Baylor College of Medicine

⸻

🧩 CLINICAL SNAPSHOTS — WHEN RHEUMATOLOGY MEETS THE BRAIN 🧠

🧠 NPSLE (Neuropsychiatric SLE)
Seizures, psychosis, cognitive dysfunction.
💊 Cyclophosphamide | Rituximab | PLEX

🌿 Neurosarcoidosis
Cranial neuropathies, myelitis, hypothalamic lesions.
💊 TNF-α blockade | Corticosteroids | Cyclophosphamide

🩸 CNS Vasculitis
Stroke-like episodes, headache, encephalopathy.
💊 Cyclophosphamide ± MMF | IL-6 blockade

🔥 Autoinflammatory Syndromes (VEXAS, DADA2, NOMID, TRAPS)
Periodic fevers, vasculitis, aseptic meningitis.
💊 IL-1 / IL-6 / TNF inhibitors

💎 IgG4-Related CNS Disease
Pachymeningitis, tumefactive lesions, CSF IgG4 elevation.
💊 Rituximab — cornerstone therapy

⸻

✨ Key Insight:
Neuroinflammation often mirrors systemic autoimmunity — early recognition enables precision, collaboration, and recovery.

⸻

🔖 #ACR25 #ACRConvergence2025 #NeuroRheum #ACRAmbassador #BrainInflammation #Autoimmunity #Rheumatology #NeuroImmunology #PrecisionMedicine

[Mithu Maheswaranathan, MD @MithuRheum]

🆕 Behçet's Disease: Let’s explore this multi-system #vasculitis 💫

👄 Oral/Genital Ulcers
🩸 DVT, Arterial Aneurysm
👁️ Uveitis
🧠 Neurologic Involvement
🖐️ Cutaneous / Pathergy

#RheumTwitter #Behcets #RheumX

[Aravind Palraj @Rheumat_Aravind]

🦠 Natural Killer (NK) Cells – The swift assassins of our immune system.

The perfect bridge between innate & adaptive immunity.

They kill without permission.
No MHC? No mercy.
Cancer, viruses, rogue cells – gone.

Here’s how they do it👇
📌 @IhabFathiSulima
#Immunology #Rheumatology #MedTwitter #NKCells

[reUNma2023 @reUNma2023]

Neuro Behcet
#visualabstracsUN

EvidenceHunt: ¿Son las lesiones de sustancia blanca periventriculares en la resonancia cerebral compatibles con compromiso cerebral por Behcet?

** Yes, periventricular white matter lesions on brain MRI are compatible with cerebral involvement in Behçet's disease. Here are some key points from the studies:

Common Findings: Periventricular white matter lesions are frequently observed in patients with neuro-Behçet's disease. In a study involving 58 patients, the most common sites of involvement included periventricular and superficial cerebral white matter, midbrain, and pons.
Int J Rheum Dis. 2012 Dec;15(6):e142-9. doi: 10.1111/1756-185X.12013. Epub 2012 Oct 27. PMID: 23253242.

[Rheuma Doc @LastManStand85]

Recommendations for the Treatment of #Behcets disease (pediatric) #Rheumatology #MedTwitter BSR25

[Dr sthanu subramanian @drsthanus]

Pancytopenia...an approach

@runthelistpod

[Antoni Chan MD (Prof) @synovialjoints]

The pathophysiology of Axial Spondyloarthritis. A review by Bittar A et al https://t.co/gewUUIrpNv #axialspondyloarthritis

[Rheumatology Quarterly @RheumQuarterly]

respiratory manifestations in #systemic #lupus #erythematosus (#SLE)

ref: https://t.co/uFz8uwrMoM

#firatromatolojisempozyumu
#romatoloji

[Dr sthanu subramanian @drsthanus]

Very useful!

Patterns of sensory loss.

A. Generalised peripheral neuropathy.

B. Sensory roots.

C. Single dorsal column lesion (proprioception and some touch loss).

D. Transverse thoracic spinal cord lesion.

https://t.co/oEHulZezNj

[Luis Caminal @caminalm]

Diagnosis and Treatment of Vasculitic Neuropathy on @PracticalNeuro https://t.co/n3w6cgic2X

[Alberto Giraldo @alb_giraldo]

The #Sjögren's Foundation has developed an evidence-based clinical practice guidelines for peripheral #nervous system (PNS) manifestations in patients with Sjögren’s disease. The objective of this work was to bring #rheumatologists and #neurologists and together to understand, define and align nomenclature used by specialists in connection with PNS involvement in Sjögren's, but could also be useful for other systemic #autoimmune diseases.

🔓 American Academy of Neurology 2024 Annual Meeting poster presentation (shared by the authors)
🔗https://t.co/HCSbgZIg2J

🔒Accepted manuscript in Arthritis & Rheumatology
🔗https://t.co/zN2u2jc3En

[Dr. John Cush @RheumNow]

Nailfold video-capillaroscopy (NVC) study of 76 dermatomyositis (DM) pts - 74% had anomalous NVC patterns (diminished density, abnl morphology). NVC abnl pts had more Raynaud's, and cluster 1 were more likely to develop ILD.https://t.co/AsZ9CU2TZU

[Irving Gatell @IrvingGatell]

1. La caída de Assad no es poca cosa.
De hecho, en los meses siguientes se va a ver que el conflicto en Siria siempre fue, potencial y realmente, más peligroso que el israelí-palestino.
Tan es así, que ahora Gaza va a pasar a segundo plano.
Te cuento rápido por qué.

[Antoni Chan MD (Prof) @synovialjoints]

Pathophysiology of calcinosis. Antonia Valenzuela at Review Course @RheumNow #ACR24

[Neuro Sjogrens @NeuroSjogrens]

🚨👀
Neurologists will be able to learn best practices for peripheral NeuroSjogrens. Will be (vs is already? See date of journal) Published in The Neurology journal !!!

https://t.co/XjRizbUr2F

[Dr. John Cush @RheumNow]

Full read JAMA ILD Review article. ILD= 33% idiopathic (IPF) + 15% hypersensitivity pneumonitis + 25% from CTD.
30% of ILD has cough
Chest CT 91% sensitive, 71% specific
5% decr in FVC/12 mos assoc w/ 2-fold incr in mortality
Rx options nintedanib or pirfenidone, TCZ, MMF, RTX https://t.co/VDmQV7xxFR

[Carlos Horacio Muñoz Vahos @doctorchmunoz]

¿Qué sabemos sobre compromiso de Arterias Pulmonares y Arteritis de Takayasu?: la afección vascular en TAK no se presenta al azar, existen 3 clusters de compromiso de grandes vasos más frecuentes en la enfermedad (1,2 y 3), y el daño de ciertos territorios cambia según el sexo🧵