Jonathan Weissman's Lab

Jonathan S. Weissman's lab at the @WhiteheadInst/@MIT. Account run by lab members.

[Manuel Leonetti @LeonettiManuel]

📣 new preprint multimodal atlas. Imaging + scRNA, 57M cells. 🧬🔬

Cells are complex dynamical systems — but most ways we measure them destroy them. We asked: how does live imaging compare to scRNA-seq, the field’s gold std?

The answer surprised us 🧵

https://t.co/RG0PZ1KTHW

[ZhuangLab @ZhuangLab]

What is the global structure of cell-state space—and how do perturbations drive transitions within it?

Excited to share our new preprint (https://t.co/ZTlAY4eaJf), a work in collaboration with @JswLab.

[Luke Koblan @LukeKoblan]

A few years in the making in the @JswLab with @WilliamNColgan, Zack Smith, and the rest of our fantastic team: Comprehensive Lineage Tracing Maps the Landscape of Cell Fate Decisions in Mouse Embryogenesis. Excited to hear everyone's thoughts!

[Jonathan Weissman's Lab @JswLab]

Special thank you to @WhiteheadInst @broadinstitute @kochinstitute @HHMI_science @czi @NIH

[Jonathan Weissman's Lab @JswLab]

Excited to share a new preprint from the lab led by @LukeKoblan and @WilliamNColgan in which we describe our efforts to define a quantitative cell fate map of mouse embryogenesis! https://t.co/ffZdHX9ikp

[Jonathan Weissman's Lab @JswLab]

This has been a wonderful collaboration between our group and Zachary Smith’s Group @yalemed and the Max Planck Institute with important contributions from @nir_yosef1 @WeizmannScience, @ZhuangLab @HarvardCCB, and Kyle Loh @Stanford

[Jonathan Weissman's Lab @JswLab]

There is plenty more in the manuscript so please give it a read, we are excited to hear feedback from the community. Stay tuned for exciting next steps!

[Jonathan Weissman's Lab @JswLab]

The scale and density of this dataset provide a framework for quantifying cell fate restriction dynamics–the frequency, reproducibility, and variance of fate decisions across embryos–and enabling a unified view of embryogenesis to uncover core principles of mouse development