Powell Lab

Lab of immunometabolism and cancer immunotherapy at the Johns Hopkins Bloomberg~Kimmel Institute. Here to discuss papers, exciting data, and distance running.

[Powell Lab @J_Powell_Lab]

Overall, the identification of these metabolic phenotypes provides insight into the dysfunctional immune response in acutely ill COVID-19 patients and provides a means to predict and track disease severity and/or design metabolic therapeutic regimens.
5/5

[Powell Lab @J_Powell_Lab]

Our recent paper evaluating #immunometabolism in #COVID19 is officially out @CellReports. Thanks to everyone at @JohnsHopkins and @HopkinsMedicine who helped make this paper a reality! https://t.co/2KeWSTUrl6
1/5

[Powell Lab @J_Powell_Lab]

Metabolic profiling also revealed MDSCs that expressed elevated CPT1a and VDAC1 in COVID19 and correlated with disease severity. scRNAseq provided clues to their possible function including release of alarmins (S100a8/9) and chemokines (CXCL2/3).
4/5

[Powell Lab @J_Powell_Lab]

We would like to thank @AnnualReviews for another opportunity to review the exciting field of #adenosine inhibition and ways to improve cancer #immunotherapy. @E_A_Thompson

https://t.co/bcg3CBrJYy

[Kellie N. Smith @SmithImmunology]

Proud that our #COVID study is now on @medrxivpreprint. Congrats to @J_Powell_Lab, @Yegnalab, Andrea Cox, Hongkai Ji, and all our collaborators for putting together this impactful study! https://t.co/ADOA3zCh9p

[Powell Lab @J_Powell_Lab]

Excited to share our new #immunometabolism work to define novel immune cells in #COVID19 giving insight into pathogenesis to target metabolism as a treatment! Reach out to hear how we are also using this approach in #immunotherapy @E_A_Thompson

https://t.co/PHzayEvPd7

[Powell Lab @J_Powell_Lab]

A big thank you to Current Opinion in Pharmacology for this opportunity! Excited to share our new review on A2AR as a target for cancer immunotherapy. @RachelSHelms1 & Jonathan Powell identify ways to bring A2AR targeting into the clinic.
https://t.co/T6N5mtwL80

[Powell Lab @J_Powell_Lab]

Thanks to the editors @NatureRevCancer, excited to have our new review by Leone and Powell posted online. Metabolism of Immune Cells in Cancer. @bobdleone @J_Powell_Lab #immunometabolism https://t.co/u5kgqymMLz

[Powell Lab @J_Powell_Lab]

Stay tuned! We are excited to be participating in this wonderful seminar series!

[ImmunoMetNet @ImmunoMetNet]

@J_Powell_Lab is our next speaker at the Online Immunometabolism Seminars.
Targeting Immunometabolism in Times of COVID-19.
Or maybe as therapy for COVID-19?
We are really looking forward to this one!

[Powell Lab @J_Powell_Lab]

Excited to share our new work in @jclinicalinvest. By targeting glutamine metabolism, we can enhance anti-tumor immunity by modulating MDSCs.

https://t.co/etTSBBPx9G

[Powell Lab @J_Powell_Lab]

@FrontImmunol this builds on previous work from our lab in collaboration with @VCAlabHopkins in @CellReports in 2015, in which we demonstrated combo DON, 2DG, and metformin as metabolic inhibitor therapy was a powerful way to inhibit skin and heart transplant rejection

https://t.co/Hcv8CTOImE

[Powell Lab @J_Powell_Lab]

if you need some non-COVID-19 reading, check out our latest in @FrontImmunol on using metabolic inhibitor therapy in combination with CTLA4Ig in skin and heart transplant to not only prevent rejection, but induce long-term tolerance!

https://t.co/SS7mrqgLUB

[Powell Lab @J_Powell_Lab]

@RJDLab congrats Ralph! very well deserved!

[Powell Lab @J_Powell_Lab]

if you're at the #TRC32020 come by this evening to see Powell lab postdoc Liz Thompson present her work combining flow phenotyping with metabolic markers to predict responses to #Immunotherapy in human peripheral blood samples! poster 7 at 7 (7&7's optional) #immunometabolism

[Powell Lab @J_Powell_Lab]

another day, another Powell lab postdoc presenting at #KSTcellmemory! come by the poster session tonight to see Hong Sun (@moonie_sun) present a poster on the role of mTOR regulation of vimentin in the T cell response! memories will be made! #KScellmemory

[Powell Lab @J_Powell_Lab]

in Banff for #KSTcellmemory? Get out of the winter chill and stop by the poster session this evening to see our postdoc Chirag Patel present on the role of TSC2 regulation in T cell memory formation!

[Cris Muñoz-Pinedo & Ernest Nadal - PRETT lab @apoptosislab]

MetaboList - February 2020
#Metabolism #Immunometabolism https://t.co/LV6pOdGlD0

[Delgoffe Lab @DelgoffeLab]

Great start to the T cell memory @KeystoneSymp with a great talk from Rafi Ahmed. Looking forward to tonight's poster session. Swing by poster 1058 to chat about our new project on the impact of metabolic disorders on T cell dysfunction and ACT. #obesetcells #DBRpostdoc