Jacob F Degner

Principal Research Scientist, Computational Genomics, Genetics Research Center @AbbVie All views expressed are my own.

[Jacob F Degner @JacobFDegner]

@anshulkundaje We want you to come give a talk! You’d be amongst friends. @jkpritch and @StevenSalzberg1 are gonna be part of the seminar series! @manoliskellis came a few years back! Sorry to spam you in multiple channels. Don’t block me! This is the last Hail Mary!

[Jacob F Degner @JacobFDegner]

This paper helps calm my nagging worry that maybe we've all been wrong about genetics and drug success. By looking at a completely new dimension of drug success/failure, they reaffirm the effect we have seen using target-indication pair progression.

https://t.co/9Wnr9yprnT

[Jacob F Degner @JacobFDegner]

I see that the internet is loving this new paper, but has the internet read the wonderful opinion on it by my former postdoc Emily King? https://t.co/lsGf6TrtMR

[Open Targets @OpenTargets]

Genetic evidence halves the odds of early clinical trial stoppage 🧬💊

Published today in @NatureGenet, @lesya_rzvvsk trained a machine learning classifier to analyse the free-text reasons explaining why 28,842 clinical trials stopped

3 key points:

https://t.co/buMPpOQzPk

[Open Targets @OpenTargets]

Genetic evidence halves the odds of early clinical trial stoppage 🧬💊

Published today in @NatureGenet, @lesya_rzvvsk trained a machine learning classifier to analyse the free-text reasons explaining why 28,842 clinical trials stopped

3 key points:

https://t.co/buMPpOQzPk

[Jacob F Degner @JacobFDegner]

There is a position on my new team that just opened! We are looking for a creative and talented data scientist or statistical geneticist to help us use human genetics to drive value in drug development.

https://t.co/53mEML1xr2

[Jacob F Degner @JacobFDegner]

We are building a new bioinformatics team at AbbVie that will work on design and optimization of novel biotherapeutics including rAAV based therapies. Please reach out and apply if you are interested! Here are the job postings:

https://t.co/nYkywdDHuw

https://t.co/UP7kEi3q96

[Jacob F Degner @JacobFDegner]

@NeBanovich @athmapai @rogerpique @LB_Barreiro @fluca2406 @jtung5 Bummer!

[Jacob F Degner @JacobFDegner]

@rogerpique Congrats Roger!

[Jacob F Degner @JacobFDegner]

@jkpritch Interesting read! The narrative style is nice and reminds me of how scientific papers from a century ago read.

[Francesca Luca @fluca2406]

Psychosocial experiences modulate asthma-associated genes through gene-environment interactions. Now epub in eLife. Lead by PhD student Justyna Resztak https://t.co/3Ab8S1ypV2

[Jacob F Degner @JacobFDegner]

There's another job opening in my department! Please follow up with me if you are interested or know a good candidate!
#hiring #jobs #bioinformatics #abbvie #pharma

https://t.co/6CnVRxVAk5

[Jacob F Degner @JacobFDegner]

I'm excited to see the work from @jkpritch's former students and grand-students at the reunion symposium! Great talk from @HannahMoots on ancestry and relatedness of ancient Mediterranean civilization kicks it off.

[Jacob F Degner @JacobFDegner]

How many SNPs do you need to estimate colocalization probabilities? One! Another great paper from Emily King's postdoc. https://t.co/S1mYBzrOaF

[Jacob F Degner @JacobFDegner]

@rogerpique Congratulations Roger!!!! You deserve all the awards!

[Jacob F Degner @JacobFDegner]

@mikelove @wolfgangkhuber I remember that night! I was completely lost when we met as I remember.

[Casey Brown @casey6r0wn]

I was happy to contribute to this paper with my former postdoc Minal. She used text mining and some serious brute force to try to understand how our community is approaching GWAS fine mapping. Your feed back is welcome!

https://t.co/fXld96XFj7

[Jonathan Pritchard @jkpritch]

It's great to see the NCAA's enthusiasm for coalescent theory.

[Jacob F Degner @JacobFDegner]

I'm looking to hire in the Computational Genomics - "Special Projects" group at AbbVie! The group addresses an an exciting and always changing set of projects and problems. Come join us! https://t.co/RyMDXi8Y8f @bioinfo44

[Jacob F Degner @JacobFDegner]

@chchatham @AbePalmer Thanks! I think figure 2 gets at this point some. We see that genetic evidence is specifically predictive when it supports target relevance for a highly similar disease to the disease the drug(s) are being trialed for (trait-indication similarity).

[Jacob F Degner @JacobFDegner]

Our paper on using human genetics to predict drug program success is out! https://t.co/klFsgx9Rpv
https://t.co/LWF7wNgbvX