Jacob Files

Harrison Society PGY1 at @VUMC_MedPSTP. @UABMSTP alum, dog dad, @SpursOfficial supporter, and aspiring ID physician-scientist.

[Jacob Files @JacobFiles93]

Hello! My name is Jake Files and I’m applying to internal medicine with an interest in combined research residency programs and infectious diseases! My scientific interests include all host-pathogen interactions and specifically viral immunology.

#Match2024 #Medtwitter

[Skye Opsteen @OASkye]

Super exciting to see our work on immune responses to acute COVID-19 in people with HIV published. Grateful for the endless support from @NerdmannID @JacobFiles93

Impact of Chronic HIV Infection on Acute Immune Responses to SARS-CoV-2:
https://t.co/hGK7POgvtK

[Jacob Files @JacobFiles93]

Looking forward to exploring different programs and meeting my fellow applicants on the interview trail!

[Jacob Files @JacobFiles93]

Hello! My name is Jake Files and I’m applying to internal medicine with an interest in combined research residency programs and infectious diseases! My scientific interests include all host-pathogen interactions and specifically viral immunology.

#Match2024 #Medtwitter

[SEMSS @SEmdphd]

#Registration, #abstract submissions, and undergraduate travel award applications are open for #SEMSS2023! Please to go our website https://t.co/5UJRzpffrv for more information on how to register and submit your work!

#physicianscientist #scienceinmedicine #travelaward

[Andrew Ewing @AndrewEwing11]

3 Oct 29, 2020, Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection
T cell activation/exhaustion markers remaining elevated in hospitalized and nonhospitalized. B cells had similar pattern of activation/exhaustion,
https://t.co/ilUJJ07yFP

[Andrew Ewing @AndrewEwing11]

Immune dysfunction after Covid19.
We've known since 2020.
We do not know if it is progressive, but w reinfections pretty high & viral persistence occurring it does not matter.
A thread from my threads - the top 12 papers showing clear immune dysregulation in chronological order!

[Jacob Files @JacobFiles93]

@MarkEPepin Interesting article about this below. Seems that they want you to discuss multiple hobbies/interests under the "Selected Experiences" section with a 750 word limit. Thoughts about whether this would be better than including it in the personal statement? https://t.co/bNAImbrlq7

[Jacob Files @JacobFiles93]

Thanks goes to @UABMSTP for allowing us to attend and @A_P_S_A for putting on such a great conference! As always, I appreciate @NerdmannID and @OASkye for the support and the exciting science that I was able to present!

[Jacob Files @JacobFiles93]

Finished Step 2 and my MS3 clinical year this past week and was able to celebrate by attending @JointMeeting! Was able to attend some amazing talks, network with program directors, and even try some deep-dish pizza!

[Skye Opsteen @OASkye]

Interested in knowing how immune activation & antigen persistence impact both acute #COVID19 & #LongCovid ? Check out our recently published review paper! @JacobFiles93 @NerdmannID https://t.co/ajll8tVBbg

[Jacob Files @JacobFiles93]

@grahamdcochrane Congrats!! 🎉🎉

[Jacob Files @JacobFiles93]

@snkash @NickBoyleMSTP @RobersonLabUAB Woo!! 🎉🎉 Congrats!

[Jacob Files @JacobFiles93]

Overall, these results suggest that vaccine-encoded adapted epitopes dampen CD4+ T-cell responses and impact HIV-specific antibody production. We believe a future "fully non-adapted" HIV vaccine may provide optimal B-cell help for improved HIV-specific antibody production.

5/5

[Jacob Files @JacobFiles93]

The last paper from my PhD dissertation was recently published in the Journal of Virology!

As always, much thanks to @goepfert_paul for his mentorship and for the rest of the Goepfert lab!

https://t.co/HUbAEV9wDD

A quick thread summarizing our findings:

1/5

[Jacob Files @JacobFiles93]

Additionally, while NAE-specific CD4+ T-cell responses correlated with HIV-specific antibodies (IgG Env Ab) in one efficacy trial, this was not found to be the case with CD4 + T-cell responses to AE.

4/5

[Jacob Files @JacobFiles93]

@OASkye Congrats!

[Jacob Files @JacobFiles93]

Started my MS3 clinical rotations a few months ago. Loving it! I also just resubmitted a manuscript from my PhD thesis project after receiving reviewer comments.

Seeing patients during the week, submitting papers on the weekend... I ALMOST feel like a physician-scientist! 😂

[Jacob Files @JacobFiles93]

@OASkye Highly recommend @tpwky for any and all interested in ID. Goes over the history, biology, and epidemiology of different pathogens.