Diary of a Sad Woman - why I hate COVID. Sun, Oct 15th - my brother picks up my mom who has just spent 2 weeks in Florida staying with my aunt post uncle’s death. Mom/dad had both attended my uncle’s funeral 2 weeks earlier. Mom comes back feeling sick.
@DrJeanneM@overton_edgar@msaagmd@JoHofmann2@SonyaHeathMD It’s amazing how fast things have moved forward, but these antibody therapies present so many logistical challenges. Our ability to identify, refer and treat in a very tight window will be really tough, exponentially more so for our more vulnerable populations.
Really excited that my first, first-author paper was officially published a few weeks ago! Extremely grateful to @goepfert_paul and @NerdmannID for the incredible mentorship and this opportunity. Also, much thanks to @BoppanaSushma @millieperez_4 and other authors for their help.
Drew McDonald was a healthy 29 year old, father of 2 when he came down with COVID-19 in late March. He enrolled in the #remdesivir clinical trial at @UABSOM under @NerdmannID @UAB_ID. Grateful that he shared his story of recovery w/ @UABNews. https://t.co/NNFRTt3VFE
@DrLuisO We have not. Admittedly in a data free zone, but CRRT should be able to remove the vehicle without major issue. What is less clear is drug levels, but given remdesivir is metabolized almost exclusively by liver, levels should be similar. Look forward to seeing hard data soon.
@DrLuisO Our strategy has been to not initiate EUA remdesivir with a GFR <15, but for those that have already been started, we have continued to complete a course even if the patient ends up on CRRT.
@IDJClub Ya, this doesn’t make sense until you step back and realize how fast things went. The initial assessment was planned for 440 enrollments, but rather than stop additional enrollments, study continued until there were enough completions to fully power study.
@IDJClub@Cortes_Penfield@unmc Nathan Erdmann md/phd at UAB w/ @TMcCarty2010, where I usually do transplant ID and HIV immunology, but have been involved in all things COVID and am a co-author on the study.
2001: anthrax
2003: SARS
2009: H1N1
2014: Ebola
2015: Zika
2020: Covid
This pandemic is historic, but health security threats are alarmingly common. We must break the reactive cycle of panic and neglect and prepare our public health and medical systems for the next threat.
In this double-blind RCT in 1063 adults hospitalized with #COVID19, a 10-day course of intravenous remidesivir was superior to placebo in shortening the time to recovery. The estimates of mortality at 14 days were 7.1% in the remdesivir group and 11.9% in the placebo group.