Jacob Heng

MD PhD. Enthusiast in science and medicine.

[Jacob Heng @Jacob_S_Heng]

Check out our latest work on potentially novel lacrimal gland cell types discovered through single-cell RNA-seq of the murine lacrimal gland in normal mice and mouse models of Sjogren's syndrome published in PNAS https://t.co/0NeqwrdPTI
#Sjogren #singlecell #RNAseq #autoimmune

[Yale Department of Ophthalmology & Visual Science @YaleOVS]

CALLING ALL YALE OPHTHALMOLOGY ALUMNI!

If you wish to attend, please email your full name, date of graduation, and updated mailing address to: [email protected]

Thank you!

[Jacob Heng @Jacob_S_Heng]

Why do uveal melanomas recur locally after enucleation with clear margins? We report such an intriguing case with a rare activating telomerase promoter mutation(c.1–124C>T) in both primary & recurrent tumors https://t.co/u2KRGED1Ky @YaleOph @BPerzia @YaleMed @YaleCancer #Melanoma

[Jacob Heng @Jacob_S_Heng]

Should MacTel patients undergo cataract surgery? Our study suggests yes but existing central EZ loss may predict subsequent vision loss which is likely to be unrelated to surgery https://t.co/QKVrrLhjJd
#JohnsHopkins #YaleOph #Retina #MacTel

[Francesco Emiliani @fe_emiliani]

It's out in the wild! A big thanks to @aaron_mckenna for letting me try what, at the time, sounded like a crazy idea, and to our editor/reviewers/proofers/staff @ACSSynBio for an incredible publishing experience that restored my faith in the system. https://t.co/zCmmNiZe87

[Francesco Emiliani @fe_emiliani]

Really excited to share this pandemic project with everyone. It works, it’s fast, it’s cheap (thanks to @nanopore amazing tech). We love it, we hope you will too. Special thanks to everyone in the lab and Aaron for his patience and support throughout.

[Jacob Heng @Jacob_S_Heng]

Autoimmune retinopathy with associated anti-retinal antibodies is a potential immune-related adverse event associated with immunotherapy in cutaneous melanoma patients. Check out our work at https://t.co/CIspG382aV #YaleOph #YaleMed #YaleCancer #BMJ #Immunotherapy #irae #melanoma

[Jacob Heng @Jacob_S_Heng]

Kudos to Karl Wahlin, PhD, for our paper on retinal and brain organoids in Frontiers:

https://t.co/hgeO6lTEgT

[Tim Stearns @StearnsLab]

For 20 years the reference human genome has had gaps and missing sequences. PacBio, Oxford Nanopore and a haploid human cell line to the rescue in the first complete human genome assembly! @aphillippy and a cast of many. https://t.co/0EwX2RuR8r

[Joshua Modell @jwmodell]

Just when you thought you knew everything about Cas9... Pleased to share our lab’s first paper, now online @CellCellPress: https://t.co/qcIBSh1ZnH. We found Cas9 transcriptionally regulates its own promoter using a natural single-guide RNA. Kudos @reworkman0, @tejapammi et al.

[Tahreem Mir @TahreemMir7]

Our study shows a 4-fold increase in drug use–related endogenous endophthalmitis hospitalizations in the United Sates from 2003 to 2016. Important consideration for ophthalmologists when evaluating patients with intraocular inflammation! https://t.co/xXOOnwgQco

[JRNLclub @JRNLclub]

.@Jacob_S_Heng of Jeremy Nathan’s lab characterizes cell populations and gene expression patterns in a mouse model of spontaneous uveoretinitis via single-cell RNAseq. @PNASNews @HopkinsMedicine #uvoretinitis #JRNLclub https://t.co/apmV2qGZaH

[Jacob Heng @Jacob_S_Heng]

https://t.co/NShqDzFrOq
Check out my presentation of my recent PNAS paper on #SingleCell #RNAseq of a mouse model of spontaneous #autoimmune #uveoretinitis on JRNLclub

[Jacob Heng @Jacob_S_Heng]

Proud to be named as a Top 10 Reviewer for JPOS in 2019 😀

[Daniel @dardeljan]

Junk? Ha! Learn how LINE-1 retrotransposons conflict with DNA replication, today in @NatureSMB! #CancerResearch #genetics; Thanks @KathleenHBurns @HopkinsMedicine @HopkinsMDPhD and our collaborators: @AHollandLab @MaintainGenome @JefBoeke @CompProteomics https://t.co/5wqrZI3Khe

[Rockefeller University @RockefellerUniv]

Congratulations to Rockefeller trustee Jeremy Nathans, the 2020 recipient of the Benjamin Franklin Medal in Life Science!

[Xiaowu Gu @XiaowuGu]

https://t.co/hgWBt0ZpUH surprised and truly honored to be selected as one of the winners. This snapshot of a mammalian developing eye is a reminder to myself of how much I enjoy developmental biology!