James Broatch

Postdoctoral Research Fellow @iHealthSportVU

[Eric Topol @EricTopol]

Sleep health has substantial impact across the whole body, as nicely summarized in this new paper
https://t.co/ezGwWJysF0

[Eric Topol @EricTopol]

The more exercise in mid- and late-life, the less Alzheimer's and all-cause dementia, adjusted for all known risk factors
https://t.co/BJlSqpEIIj

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

Effects of 8-Week High-Intensity Interval Training Intervention Regulating the SIRT1/PGC1α Pathway on Hippocampal Neuron Injury and Cognitive Impairment in Obese Rats

🔎"This study findings are consistent with previous research findings, which demonstrate that obesity leads to hippocampal neuronal damage and cognitive decline in behavior. Subsequent exercise intervention experiments found that 8-wk HIIT reduced the weight and Lee index of obese rats, ameliorated their cognitive behavior and neuronal pathology levels, and increased the expression of Sirt1 in the hippocampus of rats. Further protein-level experiments in hippocampal and prefrontal cortex tissues revealed that the SIRT1/PGC1α pathway was significantly downregulated under the influence of obesity, whereas HIIT activated the SIRT1/PGC1 α pathway to ameliorated cognitive dysfunction induced by obesity in rats."

https://t.co/w2kaotAgtO

[Abha Karki Rajbhandari, PhD @BrainBody_Lab]

Lancet Neurology article emphasizing lifestyle interventions including nutrition, sleep, stress management and exercise for not only symptom management but also disease modification in Parkinson’s. Lifestyle is not fringe!
https://t.co/PZchklKHNF

[Nick Krontiris @nick_krontiris]

This expert consensus statement provides an evidence-based summary of the impact of physiological factors, physical activity guidelines, and barriers on physical activity participation and prescription for individuals with disabilities, providing practical recommendations for prescribing and designing physical activity programs tailored to adults with disabilities.

[Prof Omid Khaiyat M.D., PhD @Omid_HopeUni]

Exercise intensity matters: the effects of aerobic exercise intensity on muscle-derived neuroprotective myokines

Peripheral & systematic mechanisms through which exercise-induced myokines impact brain function👇🏼

#exercise #muscle #brain #health

https://t.co/eNKTRdr8xq

[David Bishop (🦋 also bluespotscience.bsky.social) @BlueSpotScience]

Nice new reviews on the neuroprotective mechanisms of exercise and the importance of fitness for healthy brain ageing https://t.co/3XwRZ0zDX1

[David Bishop (🦋 also bluespotscience.bsky.social) @BlueSpotScience]

Exercise Intensity Terminology is a bit of a mess 😵‍💫
Our attempt to try & summarise some of the different approaches, and make some recommendations going forward, has finally been published in both MSSE: https://t.co/iHdsdK4Mhx & JSaMS: https://t.co/ONLEM5g8U8.

[James Broatch @JamesRBroatch]

We have a funded PhD position available to domestic students, commencing Q1 2026

Project: 'Tracking dementia resilience using novel biomarkers of exercise neuroprotection'

🗓️Open until filled
✅Eligibility: Domestic (Aus/NZ) citizens/P.R.
More info: https://t.co/4Ao0F5ALiB

[atul deshmukh @atul_deshmukh1]

Our latest collaborative work is now online
https://t.co/57fDYnvams
We explored muscle–brain cross-talk and discovered that the muscle-derived cathepsin B (a myokine) plays a key role in improving behavioral and neurogenic deficits in a mouse model of Alzheimer’s disease.

[Mikel Izquierdo @mikelizquierdo_]

💊+🏋️‍♂️= Medicine.
In our latest @TheLancetLongevity paper we argue:

👉 “Exercise prescription is medically indicated, professionally implemented, and clinically monitored.”

It’s time to integrate exercise into medication management for older adults.

Read here ➡️ https://t.co/Gmw3m6hVLl

[David Bishop (🦋 also bluespotscience.bsky.social) @BlueSpotScience]

Excited to share our latest pre-print: https://t.co/9mxteYPW5h
“Exercise induces time-dependent but not sex-specific transcriptomic changes in healthy human skeletal muscle”
Led by @DaleFTaylor with @LizReisman, @bluebirdi, @Romain_Barres, @NolanJHoffman & @JohnAHawley

🧵 1/9

[David Bishop (🦋 also bluespotscience.bsky.social) @BlueSpotScience]

🧑🔬 NEW PhD scholarship available in my lab to investigate:
"Mitochondrial Adaptations to Exercise" 🚴
🗓️ Applications close: 14 September 2025 ;
✅ Eligibility: Open to Australian & International students
More info here: https://t.co/XRudsqitgZ

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

Exercise orchestrates systemic metabolic and neuroimmune homeostasis via the brain-muscle-liver axis to slow down aging and neurodegeneration: a narrative review

https://t.co/FclURAvdXK

[Adam Sharples Ph.D -Blue Sky🦋@profadamsharples @DrAdamPSharples]

Amazing to see this collaboration paper in @CellPress @CellReports

Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration!

Led by @nir_eynon & @MacsueJ

https://t.co/dStU9gAI3J

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

Exercise Delays Brain Ageing Through Muscle-Brain Crosstalk

https://t.co/YQuSPrqXgF

[The Lancet @TheLancet]

Ageing is associated with cognitive decline & an increased risk of neurodegenerative diseases.

A new Review explores the neuroprotective mechanisms of endurance exercise & highlights the importance of cardiorespiratory fitness in healthy brain ageing: https://t.co/mSJlqtMQ6O

[David Bishop (🦋 also bluespotscience.bsky.social) @BlueSpotScience]

🧑‍🔬 NEW PhD scholarship available in my lab to investigate:
"Mitochondrial Adaptations to Ageing & Exercise" 🚴‍♂️
🗓️ Applications close: 30 March 2025;
✅ Eligibility: Open to Australian & International students
See https://t.co/meCFyi2KV8 for more info

[David Bishop (🦋 also bluespotscience.bsky.social) @BlueSpotScience]

🧑‍🔬 NEW PhD scholarship available in my lab to investigate:
"Mitochondrial Adaptations to Ageing & Exercise" 🚴‍♂️
🗓️ Applications close: 30 March 2025;
✅ Eligibility: Open to Australian & International students
See https://t.co/meCFyi2KV8 for more info

[David Bishop (🦋 also bluespotscience.bsky.social) @BlueSpotScience]

Our review: "Exercise as Mitochondrial Medicine: How Does the Exercise Prescription Affect Mitochondrial Adaptations to Training?" in ANNUAL REVIEW OF PHYSIOLOGY with @MitoPsychoBio & @matt_lee1 is now Online: https://t.co/pTwnCAW3nc