Leo James' Lab

Leo James' lab at MRC LMB in Cambridge, UK. Host-pathogen interactions, immunity to viruses, TRIM proteins and HIV. Account run by lab members.

[Patrycja Kozik @patrycja_kozik]

Postdoc position in dendritic cell and cross-presentation biology - four days left to apply:

https://t.co/WjBuXT7KIQ

Join our team to work on these coolest cells ever! 🥰

[David LV Bauer @DavidLVBauer]

Join the RNA Virus Replication Lab @TheCrick, Europe's largest biomedical institute under 1 roof!
🔴 TWO postdocs (4-6yrs)
🔴 ONE PhD student (4yrs, fully funded, all🌍)
We’re looking for bright, motivated people, with the chance to develop & shape projects independently... 1/n

[BioTechniques @MyBioTechniques]

Researchers at @UKDRI and @MRC_LMB have developed two novel therapies that target tau aggregates in the brain and have shown promise in treating dementia in mice
@w_mcewan @JamesLab9 https://t.co/3eWc1ZdjkO

[Medical Research Council @The_MRC]

Scientists have developed potential therapies that selectively remove aggregated tau proteins and improve symptoms of neurodegeneration in mice, showing a promising approach for Alzheimer’s disease.

More: https://t.co/RKaGfDTjut @UKDRI @MRC_LMB

[Leo James' Lab @JamesLab9]

@KajasteLab @lara_manganaro @DiazGrifferoLab @LubanLab @MickMenager @donna_mallery is on her way and she will present this new study from our lab:
https://t.co/17bqsneN6d

[Leo James' Lab @JamesLab9]

New study from the lab! Charged rings in the mature HIV capsid protein are required for formation of conical capsids: https://t.co/p9ItCYlYEC

[Leo James' Lab @JamesLab9]

Thanks to all authors of that study: @AlexKleinpeter @donna_mallery Nadine Renner, @AnnaAlbecka and Ole Klarhof. Great collaboration between our lab @MRC_LMB and Eric Freed's lab @NIH

[Leo James' Lab @JamesLab9]

New study from the lab! Charged rings in the mature HIV capsid protein are required for formation of conical capsids: https://t.co/p9ItCYlYEC

[Leo James' Lab @JamesLab9]

In forced evolution experiments we identified K25A compensating mutations that restore hexamer/pentamer ratio and rescue the shape of the capsid

[Leo James' Lab @JamesLab9]

We are looking for a PhD student to continue our exciting work on antiviral immune receptor Trim21! Contact us for any questions and apply here:

[UK Dementia Research Institute @UKDRI]

The UK DRI's @w_mcewan & @JamesLab9 (@MRC_LMB) have developed new therapies that selectively remove aggregated tau proteins - harnessing the unique capabilities of a protein called TRIM21.

The treatment improved symptoms of neurodegeneration in mice👉https://t.co/JDVYjtLTrE

[Leo James' Lab @JamesLab9]

@KajasteLab Thanks Anna!

[Leo James' Lab @JamesLab9]

Amazing new study from the lab on targeted tau degradation technology:

[Guido Papa @guidovir_]

Super excited to share our latest paper on a novel targeted protein degradation technology, now out in @CellCellPress. We introduce RING-Bait technology, an innovative approach to selectively target and degrade intracellular protein aggregates (1/7) https://t.co/9VZY4fVtzX

[The Science of Parkinson's @ScienceofPD]

New research from @JamesLab9 & colleagues presents 'RING-Bait', which employs an aggregating protein sequence combined with an E3 ubiquitin ligase to specifically degrade tau aggregates while sparing soluble tau (in vitro & in vivo) - impressive new tech!
https://t.co/DeaDMzcuot

[Leo James' Lab @JamesLab9]

Our recent contribution to work from Gabriella Santoro's lab with @AnnaAlbecka SARS-CoV-2 experiments. Check it out! @SS_Silvia88 @guipap_ @MRC_LMB https://t.co/UtlY36xBef

[Leo James' Lab @JamesLab9]

Great to be in Leeds for #BUNYA2024 conference! The lab is new to #bunyaviruses so we are sure to learn a lot!

[Leo James' Lab @JamesLab9]

Congratulations to @MatteoAll and @LabSchafer! And well done to us!

[Leo James' Lab @JamesLab9]

@LiWu_UIowa @UIowaMicrobio @IowaMed @NCICCR_HIVDRP @AlexKleinpeter Congratulations Alex!