Jamie Kuzich

Haematologist & Postdoc @TheDawsonLab @PeterMacCC // Immunotherapy resistance in acute leukaemia and lymphoma

[Jamie Kuzich @JantonKay]

@dgermain21 “How one gets to that status impacts the prognostic value of that status” 👌

[Itai Yanai @ItaiYanai]

How does a cell learn? In our new perspective in @Nature we propose a model where the properties of the AP-1 family of transcription factors – stress-induced feedback, regulatory combinatorics & cellular memory – encode a mechanism for cellular learning. https://t.co/Hzmq319EaD

[Liz Brem, MD @DrLizBrem]

Glofi+R-CHOP/R-polaCHP. I really like this study schema, allowed for short Dx to Tx interval to actually get a high risk group in study. #lymsm #ASH24

[Nico Gagelmann @NicoGagelmann]

CART could have it ALL.

Obe-cel results @NEJM:

👉127 pts
👉complete remission 55%
👉median event-free survival 12 months
👉1-year survival 65%
👉severe CRS/ICANS in 2% and 7%
👉survival curve plateau but limited follow-up
👉high tumor burden still a challenge

Congrats @drclaireroddie @hemedoc and colleagues!
https://t.co/UhFzfv9dYD

[Ajay Major, MD, MBA @majorajay]

Bridging RT v systemic tx retrospective before axi-cel #ASH24:
- 98 pts, 35 RT bridging alone
- CR 85% RT, 71% chemo (not significant)
- 1-yr PFS 75% RT, 49% chemo (significant)
- MV model PFS: improved PFS (HR 0.41) with RT alone
Time for a randomized trial. #lymsm

[Neil Renic @NC_Renic]

7:30: Declare big day of writing

8:00-17:00: Fail to write

17:30: Declare big day of writing tomorrow

[Jamie Kuzich @JantonKay]

@sadras_t @PeterMacRes Honoured to have one of my masterpieces featured

[Tanentzapf Lab @TanentzapfLab]

Gonna get a tattoo on my chest that reads "just because a result is statistically significant does not mean it is biologically significant" & a matching tattoo on my back that reads "just because a result is biologically significant does not mean it is statistically significant"

[Sunniyat Rahman @minimolecule]

Focal deletions of noncoding regions in cancer genomes can have unexpected consequences. Out now in @BloodJournal, we’ve discovered an intriguing mechanism of oncogene activation whereby focal deletion of a ‘promoter tether’ leads to aberrant expression of IRX3 in T-ALL. Thread👇

[Jamie Kuzich @JantonKay]

@PijpersLizzy @PeterMacCC @TheDawsonLab @ASH_hematology Thanks Lizzy — hope everything is going really well in Canada!

[Jamie Kuzich @JantonKay]

@Eddie_Cliff @PeterMacCC @TheDawsonLab @ASH_hematology Thanks Eddie!

[Jamie Kuzich @JantonKay]

@StephAn51493029 @PeterMacCC @TheDawsonLab @ASH_hematology Thanks Steph!

[Peter Mac Cancer Centre @PeterMacCC]

Dr Jamie Kuzich (@JantonKay) from @TheDawsonLab has received the @ASH_hematology 2024 Global #Research Award - one of just of 11 awarded to early career investigators from around the globe.

Watch 👇Read more: https://t.co/G8cPJpJgIk

#bloodcancer #hematology #haematology

[The Dawson Lab @TheDawsonLab]

Last month, the Dawson Lab celebrated our 10th year in action! 🎉

It was a wonderful day of laughs, catching up, and reflecting on just how far we’ve come over the last decade.

What a great looking group!

See ya in 5 years! 🥂

[Jamie Kuzich @JantonKay]

So good to finally see this out in all its glory. I remember @charles_bell92 first telling me about this system on the drive down to lab retreat in my first few weeks in the lab, and it was beautiful to see the story develop. Bravo, Charlie!

[Charlie Bell @charles_bell92]

Cofactors are a crucial part of the gene activation process. Yet, we still don't have a comprehensive understanding of how and why they are used by different genes. Proud to present our attempt to address this key question, now published
https://t.co/wdDmHDMDCI

[Dane Vassiliadis @DaneVass]

Proud to see our paper describing BARtab and bartools, two integrated software tools for the analysis of synthetic cellular barcodes is now published @CellRepMethods! We hope the community finds this work useful.
https://t.co/hoTc4bw38S

[Mark Dawson @MAF_Dawson]

Our latest paper from ⁦@TheDawsonLab⁩ - huge congratulations to ⁦@HenriettaHolze⁩ & ⁦@DaneVass⁩ who led this work - hope the lineage tracing / barcoding community find this helpful https://t.co/bkwVZGnxb0

[Michael Fischbach @mfgrp]

How to pick a problem. Today in @CellCellPress. 1/53
https://t.co/Id4YaXWuup

[Jamie Kuzich @JantonKay]

@jack_chan15 @Nature @EvanWeberPhD @MackallLab @ChScheffler @I_mun0z @JunyunLai @PaulBeavis Congrats Jack, so great to see this out!