Jarosz Lab

[Jarosz Lab @JaroszLab]

@ElliotHershberg Congratulations :)

[Brunet Lab @BrunetLab]

HUGE congrats to @clairebedbrook and @Ravi__Nath for exciting work on lifelong behavioral tracking in the killifish 🐟😎
Super cool that behavior can define discrete life stages and predict future lifespan!!
Awesome collaboration with @scott_linderman and @KarlDeisseroth!

[Alice Ting @aliceyting]

New work describes our efforts to achieve CRISPR editing of the mitochondrial genome.

https://t.co/8Jc51WnEmg

The CRISPR toolbox has revolutionized the study of nuclear DNA, but the mitochondrial genome (mtDNA) has remained out of reach, mainly because there are no known ways to deliver sgRNAs across both outer and inner mitochondrial membranes.

Yet many organisms have evolved mechanisms to transport RNAs across their mitochondrial membranes. Trypanosomes, for example, do not encode any tRNAs in their mtDNA, and must import all of them from the cytosol to support intra-mitochondrial protein translation.

We started with yeast. We engineered a strain that must repair a STOP codon in mtDNA (an arginine biosynthesis gene) to survive. After screening a library of sgRNA import sequences, we identified one that enables a small degree of functional CRISPR editing in mitochondria.

Graduate student Sifei Yin obtained these exciting results several years ago, and spent the intervening time understanding how sgRNA import works, and how to make it better. Read the paper to learn what she uncovered!

[Ralser Lab @RalserLab]

We don't know the (phenotypic) consequences of most mutations. Good news, the proteome can help! And it predicts phenotypes in new environments. https://t.co/VfDft0tAAH

[Jarosz Lab @JaroszLab]

Our latest: Directly measuring how mutations control proteins is a window into adaptation (w/ @RalserLab). Natural variants dramatically reshape the proteome, often in unexpected ways. Remarkably, these latent genome-proteome connections can predict variants' future consequences.
https://t.co/3r5Oq1zhYI

[Jarosz Lab @JaroszLab]

@Richard_She Many congratulations Richard!

[Richard She @Richard_She]

I'm excited to share that I will be starting my lab at NTU Singapore.

It is bittersweet to be moving halfway around the world. On one hand, I'm excited for a new adventure. I have spent my entire adult life chasing this dream, and it's finally happening. On the other hand, I still love America and believe in all of the good that it stands for. My parents moved here to give me the gift of the American Dream and I never thought I would experience what it's like to be an immigrant to a new country myself. I can only say that life has a way of offering blessings in disguise, and I’m grateful for this opportunity in every way.

[Jarosz Lab @JaroszLab]

@jacob_hanna Glad to hear you and those in your lab are safe — but so sorry to learn this devastating news

[Jarosz Lab @JaroszLab]

@JSheltzer Welcome to Stanford! Looking forward to connecting when you arrive

[Jarosz Lab @JaroszLab]

@multicellgenome Will have to visit soon to learn more. Thanks for the constant inspiration!

[Shady Saad @ShadySaad]

It is finally out! I am incredibly proud to share that my work has officially been published in Cell @CellCellPress!
This work was a product of years of dedication and countless hours of research in the labs of Joanna Wysocka and @JaroszLab @StanfordMed
https://t.co/wVhPnBpJhT

[RosenbergLabBCM @RosenbergLabBCM]

What RNA polymerase gets up to in the genome and how mutations happen! Out in Nature today! Many thanks to many collaborators and congrats to 1st author Jingjing Liu! https://t.co/wt4KGxJpMO.

[Jarosz Lab @JaroszLab]

Our perspective on Hsp90 as a global modifier of the genotype-phenotype-fitness map, along with its implications for evolution in nature and clinical settings, is now out in JMB. We review the existing literature, identify open questions, contextualize our recent findings on Hsp90, and present new analyses that expand the current understanding of its evolutionary impact. Congrats to @jaguilarrod and Chris Jakobson. Check it out here: https://t.co/KDTuGIIrfq

[Jarosz Lab @JaroszLab]

Excited to share a fantastic collaboration w/ @RalserLab: Linking natural genetic variants to effects on the proteome revealed how mutations drive rapid adaptation and forecast which were important in new environments! https://t.co/CIlI8fxYFE

[Jarosz Lab @JaroszLab]

@morris_lab @harvardmed @BrighamWomens Congratulations!! Will be sure to pass by and celebrate when you arrive!

[Jarosz Lab @JaroszLab]

@Caroline_Bartma Congratulations!

[Jarosz Lab @JaroszLab]

@ScienceyRosalie @BC_UCLA Congratulations Rosalie!

[Jarosz Lab @JaroszLab]

@liyuping927 @biozentrum @NCCR_AntiResist @UniBasel_en @ElginKorkmazhan So happy for you! Many congratulations!!