This World Malaria Day, I am happy to share our new paper on the pediatric CD4+ T cell response to malaria.
We followed individual T cell clones through repeated infections and found lots of cool stuff!
Scientists show that type I regulatory T (Tr1) cells dominate CD4+ #Tcell responses and underlie long-term immunity in young children and adults repeatedly exposed to #malaria. @StanfordMed@pjagannathanlab
Read more in Science #Immunology: https://t.co/7UbNTANXpl
My PhD thesis was made possible by NIH funding to a lab in Uganda. Now, ham-handed budget cuts from @realDonaldTrump and @elonmusk will halt our ongoing clinical trials to prevent malaria in Africa. Children will lose access to care because helping others is now un-American.
Scientists show that type I regulatory T cells dominate CD4+ T cell responses and underlie long-term immunity in young children and adults repeatedly exposed to malaria.
Learn more in @SciImmunology: https://t.co/MMdIy3y9yc
Excited to see our work designing novel and effective bispecific antibodies against SARS2 variants published in @ScienceTM. Grateful to my co-authors and all who supported the work @cobarnes27@BarnesLab1! https://t.co/ItUwYYKELA
My research team shares lab-space with these 3 immuno-leaders @SMuellerLab@LMackayLab@ProfBillHeath@TheDohertyInst. Interested in joining this energetic community of ~40 immunologists, as a PhD student, RA, or post-doc? Please e-mail me to discuss your ideas & plans.
¡Saludos desde Barcelona! (“Greetings from Barcelona!”) 🇪🇸 We’ve been enjoying the incredible community and science at @GordonConf#GRCMalaria and hope you had a chance to see our posters and talks!
We have a new episode out!
Dr. Prasanna Jagannathan (@prasannaj77) from @StanfordMed talks about the effects of repeated exposure to #malaria and promising vaccines and treatments to prevent reinfection. 🦠
@pjagannathanlab
Listen here: https://t.co/YT5C64btT7
For #WorldMalariaDay, we highlight this important insight and recent publication from Global Health Faculty Fellow Dr. Prasanna Jagannathan, who researches human immunology focused on malaria-specific immune responses in pregnancy and infancy. https://t.co/9gQSD9ZILB
@RwebishengyeR A good question—we should definitely consider more how vaccination and other host-targeted strategies affect innate immune cell epigenetics.
Out on @biorxivpreprint, I'm excited to share our latest deep dive into the world of mitochondrial genetics using single-cell genomics. Grateful to have worked with @LeifLudwig, @Satpathology, and many others. https://t.co/45yRkOQFPP Thread here: 1/n
Overall, our data support a model whereby:
repeated malaria exposure --> epigenetic reprogramming of innate immune cells --> regulation of inflammation --> disease tolerance of malaria
Finally, mean pseudotime of a child’s myeloid cells was highly correlated with the mean pseudotime of their hematopoietic progenitors, suggesting that epigenetic reprogramming for disease tolerance occurs at the level of hematopoietic progenitors.