Jason Nideffer

Immunologist @stanfordimmuno studying immune memory to better treat disease—tolerance is key.

[Jason Nideffer @JasonNideffer]

This World Malaria Day, I am happy to share our new paper on the pediatric CD4+ T cell response to malaria.

We followed individual T cell clones through repeated infections and found lots of cool stuff!

[Science Immunology @SciImmunology]

Scientists show that type I regulatory T (Tr1) cells dominate CD4+ #Tcell responses and underlie long-term immunity in young children and adults repeatedly exposed to #malaria. @StanfordMed @pjagannathanlab

Read more in Science #Immunology: https://t.co/7UbNTANXpl

[Jason Nideffer @JasonNideffer]

My PhD thesis was made possible by NIH funding to a lab in Uganda. Now, ham-handed budget cuts from @realDonaldTrump and @elonmusk will halt our ongoing clinical trials to prevent malaria in Africa. Children will lose access to care because helping others is now un-American.

[Science Magazine @ScienceMagazine]

Scientists show that type I regulatory T cells dominate CD4+ T cell responses and underlie long-term immunity in young children and adults repeatedly exposed to malaria.

Learn more in @SciImmunology: https://t.co/MMdIy3y9yc

[Adonis Rubio @adonisrubio99]

Excited to see our work designing novel and effective bispecific antibodies against SARS2 variants published in @ScienceTM. Grateful to my co-authors and all who supported the work @cobarnes27 @BarnesLab1! https://t.co/ItUwYYKELA

[Stanford Immunology @stanfordimmuno]

A huge congratulations 🥳🎊 to @JasonNideffer for successfully defending his thesis today on
"The Pediatric CD4+ T Cell Response to Malaria.” #PhD #thesisdefense #StanfordImmunology

[Jason Nideffer @JasonNideffer]

Check out this cool preprint on a novel bispecific antibody therapeutic—very strong work from a stellar scientist!

[Adonis Rubio @adonisrubio99]

Super happy to put out the preprint for my 1st first-author paper of my PhD journey! 🤓

[Richard McElreath 🐈‍⬛ @rlmcelreath]

Sure scientists spend decades using AI to publish nonsense statistical results but publish one giant AI rat testicle and suddenly it's a crisis

[Ashraful Haque @DrAshHaque]

My team at @TheDohertyInst are grateful to have been awarded an #NHMRC Ideas grant to work with @teichlab @Cambridge_Uni and @prasannaj77 @Stanford on T cell immunity to #malaria. With new team members joining us, it’s time to learn how to manage change in our group!

[Jason Nideffer @JasonNideffer]

Fantastic work from Šimon Borna and the Bacchetta lab @StanfordMed describing Treg instability in patients with IPEX disease!

https://t.co/SXCuUPhzyX

[Ashraful Haque @DrAshHaque]

My research team shares lab-space with these 3 immuno-leaders @SMuellerLab @LMackayLab @ProfBillHeath @TheDohertyInst. Interested in joining this energetic community of ~40 immunologists, as a PhD student, RA, or post-doc? Please e-mail me to discuss your ideas & plans.

[Jagannathan Lab @pjagannathanlab]

PhD Candidate @JasonNideffer gave a “Science In Progress” talk for @stanfordimmuno today full of hot Tr1 takes and interesting data—great job, Jason!

[Jagannathan Lab @pjagannathanlab]

¡Saludos desde Barcelona! (“Greetings from Barcelona!”) 🇪🇸 We’ve been enjoying the incredible community and science at @GordonConf #GRCMalaria and hope you had a chance to see our posters and talks!

[Immunology Podcast @ImmunoPodcast]

We have a new episode out!

Dr. Prasanna Jagannathan (@prasannaj77) from @StanfordMed talks about the effects of repeated exposure to #malaria and promising vaccines and treatments to prevent reinfection. 🦠

@pjagannathanlab

Listen here: https://t.co/YT5C64btT7

[Stanford Center for Innovation in Global Health @StanfordCIGH]

For #WorldMalariaDay, we highlight this important insight and recent publication from Global Health Faculty Fellow Dr. Prasanna Jagannathan, who researches human immunology focused on malaria-specific immune responses in pregnancy and infancy. https://t.co/9gQSD9ZILB

[IDRCUganda @IDRC_Uganda]

We’re having a blast at World Malaria Day! Our team is so excited to be here, sharing all the amazing work we do at IDRC. #malariaday #endmalaria #IDRC #WorldMalariaDay2023

[Jason Nideffer @JasonNideffer]

@RwebishengyeR A good question—we should definitely consider more how vaccination and other host-targeted strategies affect innate immune cell epigenetics.

[Jason Nideffer @JasonNideffer]

Excited to announce the availability of our @biorxivpreprint. This work was a collaborative effort by many incredible scientists! (Tweetorial below).

@pjagannathanlab
@purveshkhatri
@StanfordMed
@UCSFMedicine
@IDRC_Uganda

#Malaria #TrainedImmunity

https://t.co/gaJwr6FWQQ

[Caleb Lareau @CalebLareau]

Out on @biorxivpreprint, I'm excited to share our latest deep dive into the world of mitochondrial genetics using single-cell genomics. Grateful to have worked with @LeifLudwig, @Satpathology, and many others. https://t.co/45yRkOQFPP Thread here: 1/n

[Jason Nideffer @JasonNideffer]

Overall, our data support a model whereby:

repeated malaria exposure --> epigenetic reprogramming of innate immune cells --> regulation of inflammation --> disease tolerance of malaria

[Jason Nideffer @JasonNideffer]

Finally, mean pseudotime of a child’s myeloid cells was highly correlated with the mean pseudotime of their hematopoietic progenitors, suggesting that epigenetic reprogramming for disease tolerance occurs at the level of hematopoietic progenitors.