Jason Dyck

Professor, Department of Pediatrics
Canada Research Chair in Molecular Medicine
Director, Cardiovascular Research Centre

[Jason Dyck @JasonRBDyck]

Excited to highlight our newest study: JCI Insight - Semaglutide-induced loss of skeletal muscle mass is blunted by co-administration of ketone esters https://t.co/A5WxHpPHRP
@UAlberta_FoMD

[Jason Dyck @JasonRBDyck]

Planning to start semaglutide (Ozempic/Wegovy) in the near future? Or, have you started the medication within the past two weeks?
If so, you are invited to participate in the GLIMMER research study. We are interested to learn about how semaglutide affects your heart and muscle mass. Our goal is to improve care for patients who use this medication.
This study involves 3 in-person visits to Mazankowski Alberta Heart Institute. Each visit will take about 3 hours. To learn more and to find out if you’re eligible, please visit: https://t.co/oawIYBDZ6M
If you have any questions, please contact the GLIMMER study team at [email protected] or call 780-492-9010.

[Jason Dyck @JasonRBDyck]

Ketone Therapy Prevents Semaglutide-induced Loss of Cardiac Mass https://t.co/oKuKplm7eT

@DyckLab #Ozempic #ketones

[Jason Dyck @JasonRBDyck]

Advances in Ozempic research: weight loss without muscle loss!

Some potentially game-changing news from the @DyckLab today… our new study in mice shows that drinking ketone esters while taking Ozempic prevents the loss of cardiac and skeletal muscle without impacting fat loss.

[Shubham Soni @Shubham_Soni26]

With so much attention on ketones helping the failing heart, let's not forget about the other organ systems affected in heart failure. We've reviewed, and encourage exploring, the non-cardiac effects of ketones on exercise intolerance in HF @JasonRBDyck https://t.co/S3McPaqkQW

[Jason Dyck @JasonRBDyck]

Our latest publication with an outstanding team in the Netherlands.

Potential Benefits of Ketone Therapy as a Novel Immunometabolic Treatment for Schizophrenia
@DyckLab

https://t.co/9uaWpuz8CV

[Jason Dyck @JasonRBDyck]

@JussherLab @Amurtab @UAlberta_Pharm Yeah, yeah, congratulations but what the heck is he eating?!

[Jason Dyck @JasonRBDyck]

University of Alberta researchers raise concerns over muscle loss with popular obesity drugs https://t.co/2eMeHwpvDI

[Jason Dyck @JasonRBDyck]

🧵 3/3

Given the growing number of people taking this drug who have no cardiovascular disease or who are not classified as obese, “we suggest that cardiac structure and function be carefully evaluated in previous and ongoing clinical studies.”

[Jason Dyck @JasonRBDyck]

🧵1/3

Our study may require some context:

We started this work to establish a mouse model that we could use to study why some clinical trials using #Ozempic reported loss of skeletal muscle mass.

Using mice, we found that heart muscle is also decreased with Ozempic

[Dyck Lab @ualberta @DyckLab]

We are excited to share our latest paper:
Semaglutide Reduces Cardiomyocyte Size and Cardiac Mass in Lean and Obese Mice | JACC: Basic to Translational Science https://t.co/5qlNlPqZpf

[Jason Dyck @JasonRBDyck]

🧵2/3

The decrease in heart size induced by Ozempic occurred in both obese and lean mice.

This leaves us with a number of questions- 1) does this also occur in humans? 2) is the detrimental? 3) is this reversible? 4) can this cause later onset cardiac issues?

[Dyck Lab @ualberta @DyckLab]

We are excited to share our latest paper:
Semaglutide Reduces Cardiomyocyte Size and Cardiac Mass in Lean and Obese Mice | JACC: Basic to Translational Science https://t.co/5qlNlPqZpf

[Jason Dyck @JasonRBDyck]

Semaglutide Reduces Cardiomyocyte Size and Cardiac Mass in Lean and Ob... https://t.co/yH20b31dvv

[Circulation @CircAHA]

#Editorial on @krisberghansen et al. on ketone therapy in HF #AHAJournals https://t.co/cMpb90I2v1

[Dyck Lab @ualberta @DyckLab]

Huge congratulations also goes out to our postdoc @MattDMartens for being awarded a @CIHR_IRSC Postdoctoral Fellowship!!

🎉 Congrats Matt on this fantastic achievement 🎉

[Dyck Lab @ualberta @DyckLab]

Mya also earned a Medical Sciences Graduate Program Scholarship from @UAlberta_FoMD, a Walter Johns Graduate Fellowship from @UAlberta and a Grant for Women Graduate Students from @soroptimist!

Congratulations Mya! 🎉

[Dyck Lab @ualberta @DyckLab]

The lab is thrilled to share that Masters student, Mya Schmidt, was ⭐️awarded⭐️ a CGS-M from @NSERC_CRSNG for her work on ketones and inflammation!

[Dyck Lab @ualberta @DyckLab]

We're welcoming undergraduate student Darius Sahid to the lab this summer!

Darius was funded by a summer studentship from the @UAlberta Undergraduate Research Initiative 🎊

[Dyck Lab @ualberta @DyckLab]

Congratulations goes to @DaniaAlRimawi who successfully defended her undergraduate honours thesis last month!

We're proud to share that Dania was ⭐️awarded⭐️summer studentships from @NSERC_CRSNG, @WCHRIUofA and @ABInnovates to keep her research going this summer!

[Dyck Lab @ualberta @DyckLab]

We're excited to share that PhD candidate and all around ketone expert, @Shubham_Soni26, successfully defended his PhD Thesis this week!

Congrats Dr. Soni! We cannot wait to see what you accomplish as a clinician scientist!