Josh

Abib. 7th day. Space, Matter and Time. Wisdom not recklessness wins the war. Due your own diligence. Information here is only for educational purposes.

[Josh @Jcaptrading]

@hanz333_ Anyone finding mold issues and the connection with allergies.

[James Clear @JamesClear]

Be forgiving with your past self. What's done is done. No sense in beating yourself up about it.

Be strict with your present self. Win the moment in front of you right now.

Be flexible with your future self. There are many paths to success. You don't need life to be a certain way to live well.

[BowTied Biohacker @BowTiedUM]

We see this paradoxical reaction pattern constantly and it tells us something extremely important

Excess intracellular calcium drives glutamate excitotoxicity, depletes magnesium from the cell, collapses the mitochondrial membrane through the permeability transition pore, and floods potassium out of the mitochondria and cell entirely. Sodium rushes in, water follows, and cells swell toward death.

GABA receptor density drops. The GAD enzyme that converts glutamate into GABA starves for cofactors.

The nervous system recalibrates around hyperexcitability as its new baseline, and any sudden inhibitory input from a supplement triggers a compensatory excitatory snap back

Vicious cycle with no fast or easy fix, but it is simple:

GAD requires UVA and UVB light to be activated and run efficiently. Morning sunlight in the eyes and on the skin within the first hour of waking is the rate limiting factor for whether the nervous system can even produce GABA from the substrates we throw at it

Blue light and nnEMF actively promote calcium efflux from cells, which is the exact mechanism driving the hyperexcitability

Topical magnesium chloride to the back of the head and neck carries magnesium directly into the brainstem, bypassing oral tolerance entirely

No bowel flush or paradoxical rebound

Full body magnesium chloride baths (2 to 4 cups of flakes in warm water, 20 to 40 minutes) flood the tissue compartment through the skin and are one of the fastest ways to begin correcting whole body depletion without touching the gut.

Oral magnesium chloride dissolved in water (quarter to half teaspoon of flakes per liter, sipped throughout the day) provides steady state systemic delivery.

The glycine conjugate is responsible for the paradoxical effects.

Magnesium acetyl taurate is the actual brain and CNS magnesium, the only form worth using for targeted cognitive and neurological support. Comparable to an 0.25mg of XANAX.

Add taurine at 1 to 3 grams daily (potent antioxidant, GABA modulator, electrolyte regulator, mitochondrial support).

Add inositol at 3 to 6 tablespoons dissolved under the tongue or in water for intrusive and ruminating thoughts.

Build your own GABAergic herb cocktail and drink it as tea throughout the day and before bed.

- Magnolia bark (honokiol hits benzodiazepine receptor sites at diazepam level potency without dependency risk, magnolol agonizes CB2).
-Lemon balm (GABA A positive allosteric modulator, GABA transaminase inhibitor)
-Holy basil
-Skullcap
-Lavender (GABA A potentiator). Ginger
-Gotu kola
-Stachys officinalis
- Blue lotus for the deeper calm and dream restoration

All of these are available on Etsy as loose herbs, and making custom tea blends is one of the most cost effective and enjoyable ways to deliver daily broad spectrum GABAergic support to get you feeling good TODAY

Oral progesterone is mostly converted to Allopregnanolone in the liver, another potent GABA A PAM, and highly recommended if low

Pinealon penetrates straight through cell and nuclear membranes and binds directly to DNA at specific promoter sequences including SOD2 and GPX1

It doubles antioxidant activity in hypoxia vulnerable brain tissue, restores hippocampal spine density by 71% in Alzheimer's models, and suppresses the inflammatory ERK1/2 signaling cascade driving excitotoxicity

1-2 mg oral fasted AM with real sunrise exposure

Pinealon is one of the most targeted tools available for calming excitotoxicity while simultaneously driving neuroplasticity and receptor remodeling

B vitamins require a propersequence:

Thiamine first (the active form TPP needs ATP and magnesium just to be created). Riboflavin second (it converts nearly every other B vitamin into its active form and requires iodine, selenium, and molybdenum to function). Methylation support comes last.

Skipping this order is why B vitamins cause paradoxical responses.

Exogenous melatonin is unnecessary when the light environment is correct. 95% of melatonin is produced by mitochondria, driven by near infrared light hitting cytochrome c oxidase.

The remaining pineal fraction requires darkness after sunset. Morning sunlight programs tryptophan for melatonin synthesis that evening. Red and NIR light panels in the morning and late afternoon, complete darkness or firelight after sunset, and the body produces its own melatonin in quantities no supplement can match.

Somatic bodywork and parasympathetic vagal stimulating breathing practices should be happening nearly every waking hour at the beginning of this process.

The nervous system did not become dysregulated overnight and it will not rebalance from a five minute session before bed. Extended exhale breathing (four count inhale, seven to eight count exhale), humming, gargling, cold water on the face, gentle movement, and any practice that activates the ventral vagal complex need to become the background rhythm of daily life until the system begins holding parasympathetic tone on its own.

GABA receptor upregulation takes three to six months of consistent daily input for notable improvement, though many find Cortexin provides 3-4x faster improvements.

[Patrick OShaughnessy @patrick_oshag]

My conversation with Alex Sacerdote, founder of Whale Rock Capital Management.

Alex runs more than $17B and has been one of the best performing tech investors for years, though he keeps a low public profile.

As you'll hear, he is singular in how he thinks about investing through technology cycles.

For over 25 years, he has built his entire investment framework around a single idea, the S-curve.

We discuss:
- The AI L-Curve
- When to buy into an S-curve and when to sell out
- The de-commoditization of data center hardware
- Why he went net short software
- His two models for tech adoption
- Finding alpha

Enjoy!

Timestamps
0:00 Intro
9:55 AI's L-Curve
19:31 Whale Rock's S-Curve Playbook
26:14 Spotting Inflection Points
32:02 Finding AI Winners
40:04 AI vs Software
48:13 The Hardware Renaissance
58:04 Why Investors Miss AI
1:05:18 Whale Rock's Research Machine

[Men's Standards @MensStandards]

Most men enter marriage focusing on the wrong things...

Focus on these instead:

[George Ferman @Helios_Movement]

B9 is not only important for people with MTHFR SNPs.

It's far more crucial for our mood, brain, libido, hormones, cardiovascular health, and energy levels than most people think.

Here's what you need to know.
Thread 🧵

[Died Suddenly @DiedSuddenly_]

Most parents have no idea what’s in the shots they give their kids.

Do you recognize a single name he reads off? These are all going into infant children.

Doctors rarely show this to parents, I wonder why.

[Denise K Shull @DeniseKShull]

It’s so tragic.

And one amazing fact is that @SabinehazanMD predicted something along these lines over 5 years ago.

[Joël Bomane 🇫🇷 🌎 @JoelBomane]

@Ric_RTP

[Rich Posson: ReformationAdamSmith @rich_posson]

Agree. Fits with my cyclical stance on society, civilization, business, markets and economy. We are in a crisis.

[AXEC @EgmontHandtke]

“In 1879, JP Morgan paid a man to invent the lie that is the foundation of modern economics. A billionaire [Nick Hanauer],who helped start Amazon just exposed the whole thing on Diary of a CEO, and once you hear it you will never look at paychecks the same way again …So JP Morgan personally brought a man named John Bates Clark to Columbia University, which was essentially the intellectual headquarters of Wall Street, and told him to fix the problem. Clark wrote a … which claims that because markets are perfectly efficient, the amount of money you earn reflects EXACTLY the value you contribute to the economy.” (Ricardo)

Economics has long been known to be failed/fake science. Economists do not understand to this day how the economic system works. Distribution Theory is a smoking gun proof.

In short: (i) Profit is the foundational concept of economics, (ii) economists have not gotten it right since the founding fathers, (iii) Distribution Theory is false by logical implication.

The free-market economy runs on profit. Macroeconomic profit is given by the axiomatically correct Profit Law / Balances Equation (I−Sm)+(G−T)+(X−M)−(Qm−Yd)≐0.

For a start, the formula can be reduced to Qm≡−Sm, i.e., the profit of the business sector is equal to the dissaving of the household sector, or, the loss of the business sector is equal to the saving of the household sector. ⇓ Profit/loss has nothing to do with marginal productivity.

This means, first of all, that Clark's marginal theory of distribution is proto-scientific garbage. However, “… it worked so well that it got absorbed into mainstream economics and is STILL taught as a foundational principle to this day.”

Because the Profit Theory is provably false, the Distribution Theory is false. And because of that, economics is failed/fake science.

Even if all academic economists were fired tomorrow, there would be no loss of scientific content.

Whether JP Morgan corrupted John Bates Clark is a moral question that has nothing to do with the scientific status of Clark's approach. Moral condemnation is not the same thing as scientific refutation. Clark's marginalism has been scientifically dead from the outset. That alone decides the matter.

Nick Hanauer and Ricardo are storytellers, not competent scientists. The competent economist delivers the correct Distribution Theory.

[Afshine Emrani MD FACC @afshineemrani]

I'm a cardiologist. I've held dying hearts in my hands in the cath lab at 3 AM. And I need to tell you something that changes everything about how we prevent heart attacks.

For decades, the entire field was built on one target: lower LDL cholesterol. Statins save lives — that's settled science. But too many of my patients did everything right — took their statins, hit their numbers, lived clean — and still ended up on my table with a ruptured artery.

We were treating the smoke while the fire kept burning.
The fire is inflammation. And the evidence is now overwhelming.

The CANTOS trial proved it first — lowering inflammation independent of cholesterol reduced cardiac events. But the newer data is what keeps me up at night.

AI-enhanced CT angiography can now detect inflamed arteries by measuring changes in the fat surrounding your coronary vessels — the perivascular fat attenuation index. Higher inflammation in the fat around even one artery independently predicts cardiac death. When multiple arteries show inflammation, the risk multiplies dramatically — even in patients whose cholesterol looks perfect.

This isn't theoretical. This is measurable. Right now. On a scan you can get this month.

Low-dose colchicine — a drug that's been around for centuries for gout — is now FDA-approved specifically for reducing cardiovascular events. It works by quieting the inflammatory cascade that destabilizes the plaque sitting in your arteries. A pill that costs pennies is saving lives the statins couldn't reach.

And the next wave is already in Phase 3 trials. Ziltivekimab — an IL-6 inhibitor — targets the central inflammatory pathway driving atherosclerosis. Phase 2 data showed a 90% reduction in hsCRP. The ZEUS cardiovascular outcomes trial is enrolling now, with results expected late 2026 into 2027. If positive, anti-inflammatory therapy will become standard in managing heart disease alongside lipid-lowering. The era of inflammation-targeted cardiology is arriving.
But it goes deeper than drugs. AI is now predicting heart failure and cardiac events 5+ years before symptoms — integrating CT imaging, electronic health records, and genetic data with accuracy that jumps far beyond traditional risk calculators.

And polygenic risk scores — a simple genetic test that flags inherited cardiovascular risk — are now formally recognized as a risk-enhancing factor in the 2026 ACC/AHA guidelines. A single blood draw can reveal risk that's been silently building since birth. Decades before the first chest pain.

Here's what this means for you right now — today:
Ask your doctor for a high-sensitivity CRP test. It's cheap, routine, and measures the systemic inflammation that standard cholesterol panels completely miss. You can have perfect LDL and inflamed arteries that are quietly preparing to rupture.
If your hsCRP is elevated, discuss low-dose colchicine with your physician. It's FDA-approved for exactly this.
Push for a coronary CT angiography with AI plaque and inflammation analysis if you have risk factors. This isn't the stress test your parents got. This is 3D visualization of your actual arteries — with AI quantifying not just how much plaque you have, but what kind it is and whether the surrounding tissue is inflamed.
Consider polygenic risk score testing — especially with a family history of early heart disease. It's now guideline-supported.

And the foundation that never changes: move daily, eat real food, sleep 7-9 hours, manage stress, and know your numbers — ApoB, Lp(a), hsCRP, fasting insulin.
I left Iran as a child with nothing. I rebuilt everything in a country that gave me the freedom to become a physician. I've spent twenty years watching patients get second chances.

The ones who haunt me aren't the ones who died on my table. They're the ones who survived but never acted on what the science was telling them — years before the event that didn't have to happen.

You can have perfect cholesterol and still have a heart attack. Inflammation plus genetics can drive plaque rupture in arteries that look "fine" on a standard panel.
The myth that normal cholesterol means you're safe has cost more lives than I can count.

We now have the tools to detect the fire — not just the smoke. AI to see it. Genetics to predict it. Drugs to quiet it. And the ancient basics — movement, real food, sleep, purpose — to prevent it from starting.

Prevention is the new cure. And the science to make it real is no longer coming.
It's here.

[unknown girl🪐 @Velcro_Tearss]

There's a beautiful saying that goes like this:

[alpha man @alphaman_111]

Here Are The 8 Gnuine Green Flags In a Woman (The Ones That Actually Matters Long-Te

1. Family-oriented & loyal

[BILLIONAIRE UNIVERSITY® @TheBillionaireU]

He borrowed $2,000 from his father and built a $20B a year tech company. 😓

David Steward grew up in poverty in segregated Missouri, where he was denied access to public spaces because of his race. After starting out in sales, he launched a small auditing business before cofounding World Wide Technology in 1990.

Major contracts with companies like Cisco, Microsoft and government agencies helped fuel rapid growth. Today, World Wide Technology generates around $20B in annual revenue, and Steward is worth an estimated $11.4B making him the richest Black person in America.

[Book Therapy @Book_therapy223]

Years hoping they'd reach your depth — only to realize they never wanted to.

[Mindset Machine  @mindsetmachine]

A weak man needs constant validation.

A strong man needs constant standards.

Raise them. Live by them. Never apologize for them.

[Book Therapy @Book_therapy223]

Let it unfold. Pour time into your people, stack real memories, and guard your energy.