Jennifer Modamio

[Danielle Beckman @DaniBeckman]

Not all organs respond equally to #COVID infection. DISCO-seq, a new technique led by my talented friend @HarsharanBhatia, combines 3D imaging and single-cell analysis to map Spike Protein tropism and found mostly in the liver, lungs, intestine & kidneys. https://t.co/9dA0axeUbU

[Ali Max Erturk @erturklab]

Today in @Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell.
In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. 🧵👇🔉
https://t.co/BERf5GQ10Z led by @Dorie00 & @yingchen733

[Ali Max Erturk @erturklab]

Does brain aging always mean vessel loss?
🧠We found a surprising hypervascularization, driving cognitive decline & blood-brain barrier damage in aging. 👇🧵https://t.co/i3pWeowcLQ Led by @MihailMuc

[Ali Max Erturk @erturklab]

Most transcriptomics studies sample ~0.001% of a mouse. Which region to choose? Often we guess.

We introduce DISCO-seq🤗flipping the order:
Whole-body 3D imaging with RNA-preserving clearing→ pick ROIs in 3D→ unbiased scRNAseq
Led by @HarsharanBhatia
https://t.co/kYkzAWC5K9

[Karoline @kalorintschi]

Excited to share the main project of my PhD✨ We used DNA hybridization to attach targeting ligands to lipid nanoparticles (LNPs), enabling cell-specific delivery in vivo. #DrugDelivery #LNP #Nanomedicine

[cerenkimna @cerenkimna]

We merge the programmability of DNA nanotechnology with the versatility of lipid systems. Introducing LipiGo, engineered to detarget the liver upon systemic administration and enable precise active targeting 🎯

[Ali Max Erturk @erturklab]

We are introducing LipiGo 🤗
A programmable DNA–lipid nanocarrier 🧬 with built-in targeting logic.
It de-targets the liver and redirects mRNA delivery into lymphoid organs, enhancing therapies requiring the immune system. by @cerenkimna @kalorintschi https://t.co/moldTeozmj
1/n

[Nature Biotechnology @NatureBiotech]

Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning https://t.co/4RhnmhJ0PE

[Ali Max Erturk @erturklab]

LNP/mRNA therapeutics and AAV-based approaches require cell-level precision to achieve success without significant toxicity to other cells. To enable this, we now introduce SCP-Nano🤗 in @NatureBiotech: an AI-based technology for precision nanotechnology. https://t.co/1YniGZr4O4

[Ali Max Erturk @erturklab]

Our new study shows that SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it🔬🧠🦠🧵👇@cellhostmicrobe https://t.co/IEGx7HIrXf

[Eric Topol @EricTopol]

The #SARSCoV2 spike protein can persist in the brain—skull bone marrow and meninges—to induce neurologic damage https://t.co/FtsftML1m4 just published @cellhostmicrobe @erturklab open-access

[Ali Max Erturk @erturklab]

🎉We're thrilled to announce the #MICCAI2024 SELMA challenge on self-supervised learning for 3D light-sheet microscopy image segmentation.
Explore our dataset, which contains 3D light-sheet microscopy images of various labeled structures and is possibly the largest 3D microscopy image challenge dataset available.  Join us in advancing 3D image segmentation in biomedical research!
The training set is released now. Check it out: https://t.co/SUSzv8pSRG

[Ali Max Erturk @erturklab]

Roger @jieluo692 blew the minds of the audience with his research, developed among many with Ying Chen et al., presenting new deep learning-based nanotechnology DISCO, for cell-level imaging of nanocarriers in whole mouse bodies during the cancer immunotherapy meeting by BioNTech and Tron #CIMT2024

[Nature Methods @naturemethods]

The DELiVR pipeline enables deep learning-based analysis of neuronal activity or other processes in the brain after tissue clearing and light-sheet imaging. DELiVR’s virtual reality approach facilitates the generation of training data for deep learning.
https://t.co/dOaFfRzyLj

[Ali Max Erturk @erturklab]

Very excited to share that our DELiVR method is now open access published @NatureMethods. We created a simple, brain-wide cell analysis deep learning tool, no coding needed! Fiji Plugin makes it accessible to all. https://t.co/qjFk3p5aba
by @Dorie00 @Rami96614090 @moritz_negwer

[Nature Biotechnology @NatureBiotech]

The April issue is live https://t.co/wVzwnybjTU

Our cover shows an image of a whole mouse body with depth color-coding of a neuronal marker. Mai et al. present wildDISCO, a method for whole-body imaging compatible with standard IgG antibody labeling https://t.co/POOiYZVyGS

[Ali Max Erturk @erturklab]

Very excited to see our work wildDISCO at the cover of Nature Biotechnology https://t.co/544CH1IIRw

[Jennifer Modamio @JenniferModamio]

RT @erturklab: 🌟 End-of-Year Opportunity 🌟
Looking forward to your next career move? Join our vibrant teams!
We have multiple openings for…

[Ali Max Erturk @erturklab]

🔬🌟 Join our Innovative Team at @HelmholtzMunich!

We're excited to announce an opening for a Staff Scientist in Tissue Clearing & Image Analysis at our lab. Be part of a team that's pushing boundaries in bioengineering, AI, and more!

We are at the forefront of combining biology, chemistry, engineering, and computer science. We specialize in developing advanced cellular imaging technologies and deep learning algorithms for analyzing large data. We aim to develop treatments for complex diseases including Alzheimer’s disease and cancer by accelerating scientific discoveries with this unique technologies and approach.

Your Role:

Maintain advanced light-sheet microscopes
Implement tissue-clearing projects and collaborations
Support in data analysis and infrastructure

We're looking for:

Passionate individuals with a background in Life Sciences, Optical Physics, or similar fields
Experience in tissue clearing, fluorescence microscopy, and image analysis automation
Fluency in scientific English.

Why Helmholtz Munich?

· We value diversity and inclusivity, believing it drives innovative research
· We offer a dynamic work environment, health promotions, and personal development opportunities
· Flexible working hours and comprehensive benefits

Interested in making a meaningful impact in health research? Contact us for more details and join our diverse team committed to excellence and innovation!

Apply now: https://t.co/oyitRPsQgZ

#ScienceCareers #BiotechJobs #DiversityInSTEM #Innovation #MunichJobs #DISCO #Clearing #AI #imaging #deeplearning

[Helmholtz Munich | @HelmholtzMunich @HelmholtzMunich]

🤖#AIatHelmholtzMunich

Clear detailed view into the body!
Prof Ali Ertürk & team @erturklab developed #wildDISCO, a revolutionary method mapping entire bodies for high-resolution images.
👉https://t.co/f8IxoI3Yuq

📽️Watch Prof. Ertürk's fascinating explanation of wildDISCO👇
#AI