Doris Kaltenecker

Lead Scientist @HelmholtzMunich | Metabolism | Cancer Cachexia | Transcriptional regulation | Tissue clearing l Light-sheet imaging

[Doris Kaltenecker @Dorie00]

Incredibly happy to see our work published in @Nature today
🥹

By combining whole-body tissue clearing, light-sheet microscopy and AI, we mapped obesity-associated remodeling across the entire mouse body in 3D at cellular resolution

https://t.co/IQJX6OHmXV

[Ali Max Erturk @erturklab]

Today in @Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell.
In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. 🧵👇🔉
https://t.co/BERf5GQ10Z led by @Dorie00 & @yingchen733

[Matthias Mann Lab @labs_mann]

1/5
Cell identity is written in the proteome, not in the DNA, and not always in the RNA. Out on bioRxiv today: The first cell type-resolved, MS-based proteomic atlas of the human body.
https://t.co/5RJ0nVoQ81

[Ali Max Erturk @erturklab]

Our recent work in @Nature, MouseMapper uses foundation-model AI, mapping perturbations in mouse body cell-by-cell, revealed unexpected facial nerve damage.
Proud to see >75K accesses & >60 news stories in the first week.
https://t.co/BERf5GQ10Z
next come>https://t.co/kYkzAWBxUB

[Marcus Goncalves @MarcusDGon]

Authors used MouseMapper to study diet-induced obesity, and identified structural alterations of the infraorbital branch of the trigeminal ganglia https://t.co/CmdWGMp0aP

[Peter Ottsjö @peterottsjo]

This image is not an illustration. It’s whole mouse bodies made transparent, with nerves, immune cells, organs and tissues lit up in 3D.

It looks pretty cool! But the real story behind the image is even better. 🧵 (1/6)

[nature @Nature]

Nature research paper: A deep-learning framework reveals whole-body perturbations at cell level

https://t.co/8xskf617WT

[Ali Max Erturk @erturklab]

If you missed the video for our recent @Nature study, check it out 👇🏼 Turn on the sound! We added some art to it 😊

[Samuel Hume @DrSamuelBHume]

This is super cool: direct visualization of inflammation in an obese mouse

[Melinda B. Chu @MelindaBChu1]

This is so cool! Billions going into virtual cells, but I think Something like MouseMapper is way more helpful for translational research and pharma R&D as pathology is more than just 1 cell or receptor. It looks like the mice are dancing in a disco and they have the DISCO tissue clearing and light sheet microscopy methods too. 🐁🕺🪩👩🏻‍🔬👩🏻‍⚕️😎

[Doris Kaltenecker @Dorie00]

@HarsharanBhatia @Nature @erturklab Thank you Harsh! 😊

[Harsharan Bhatia @HarsharanBhatia]

Thrilled to share our recent work of MouseMappe @Nature kudos to @Dorie00 and team @erturklab for their relentless commitment towards this work, which shows power of AI foundation-model and DISCO-MS spatial proteomics to detect and map subtle changes in whole body of obese mice!

[Derya Unutmaz, MD @DeryaTR_]

Amazing whole body BioAI foundation model from Ali’s lab! Congratulations for the Nature paper!

[Eric Topol @EricTopol]

An AI foundation whole-body 3D model that assesses perturbations (such as obesity) across multiple systems (such as immune, neural) at the cell level. This is MouseMapper. Imagine HumanMapper someday @Nature @erturklab https://t.co/jsg3VMzOqg

[Doris Kaltenecker @Dorie00]

Very grateful to everyone who made this possible! Special thanks to @erturklab @IzabelaHorvath @Rami96614090 @yingchen733 @ilginkolabas and all co-authors for the amazing teamwork. Some dreams do come true 😀

@HelmholtzMunich @helmholtz_diabc @LMU_Muenchen

[Doris Kaltenecker @Dorie00]

Incredibly happy to see our work published in @Nature today
🥹

By combining whole-body tissue clearing, light-sheet microscopy and AI, we mapped obesity-associated remodeling across the entire mouse body in 3D at cellular resolution

https://t.co/IQJX6OHmXV

[Ali Max Erturk @erturklab]

Today in @Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell.
In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. 🧵👇🔉
https://t.co/BERf5GQ10Z led by @Dorie00 & @yingchen733

[Pauline Morigny @MorignyPauline]

I am very happy to share our latest paper on cancer cachexia out in JCI !✨This study is the follow-up of our previous findings on the link between bioactive lipids and cachexia. We show that blocking ceramides’ synthesis improves body wasting and uncovered underlying mechanisms.

[Maria Rohm @RohmMaria]

Happy to share our latest paper showing that liver-derived #ceramides drive #muscle dysfunction in #cancer #cachexia . Study led by @MorignyPauline at
@helmholtz_diabc

[Ali Max Erturk @erturklab]

Does brain aging always mean vessel loss?
🧠We found a surprising hypervascularization, driving cognitive decline & blood-brain barrier damage in aging. 👇🧵https://t.co/i3pWeowcLQ Led by @MihailMuc

[Delgoffe Lab @DelgoffeLab]

Dearest gentle reader, we are delighted to announce a new story from our lab published in @Nature describing how a meal's systemic metabolic changes are interpreted by your immune system to enhance adaptive immunity. A thread 1/ https://t.co/zACqCLxDMU

[Jie Luo @jieluo692]

We are thrilled to announce that the detailed wildDISCO protocol is now available online in Nature Protocols. We hope this protocol will facilitate the wider use of our whole-body antibody staining technique. Thank you so much for all your efforts, especially @erturklab and @HongchengM.

[Doris Kaltenecker @Dorie00]

@jieluo692 @natBME @PurdueChemE @ImphPurdue @PUCancerInst Congrats!