Matthew Jensen

Post-doctoral associate in the @gersteinlab at Yale; former grad student in the @girirajanlab at Penn State; interested in genetics of complex human disorders

[Matthew Jensen @JensenGenetics]

Excited to be presenting our recent PsychEncode work on population-scale single-cell sequencing of 388 brains at #eshg2024 tomorrow! Come check out my talk at session C22. @GersteinLab

[Matthew Jensen @JensenGenetics]

Also check out my talented labmates' posters on the 16p12.1 deletion project at #ASHG21: Corrine Smolen (poster #2852), @lucilla_pizzo (poster #3431), and Anastasia Tyryshkina (#3098). And special thanks to everyone who worked with me on these exciting projects!

[Matthew Jensen @JensenGenetics]

I'm settling in to my new post-doc position with the @GersteinLab, but I have some exciting news from my graduate work in the @girirajanlab! 1) Our work on rare variants that disrupt expression in complex diseases was published today in Genome Medicine: https://t.co/XsWGLyfUKT

[Matthew Jensen @JensenGenetics]

2) I'll be presenting results from our broader study of rare variant combinations that act as "second-hits" for complex disorders at a platform talk during #ASHG21. Come check out our work on Wednesday at 11AM (session 1161)!

[Matthew Jensen @JensenGenetics]

Very interesting new work from my grad school labmate @evercuriousVj! This method will allow researchers to look more closely at combinations of rare variants related to disease, instead of just single genes.

[Santhosh Girirajan @girirajan16]

I’m very excited that my talented grad student Vijay's @evercurious work is now on @biorxivpreprint. We developed a computational framework for identifying oligogenic etiologies (digenic, trigenic, etc) for complex disorders. 1/n @BioinformPSU @PSUScience
https://t.co/dSaQCBZnhP

[Matthew Jensen @JensenGenetics]

A bit late in this (as I also had to move out of my apt), but I turned in my PhD thesis to my committee last week….less than one week to go until my defense 🤞

[Lucilla Pizzo @lucilla_pizzo]

Wonderful experience to have presented my first platform talk at @TheACMG meeting! We showed the relevance of WGS in patients with rare CNVs from our work with @JensenGenetics from @girirajan16 lab at @PSUScience! #ACMGMtg21

[Matthew Jensen @JensenGenetics]

Our new paper on the transcriptomic effects of the 16p12.1 deletion is out on bioRxiv today. Working on this project, I learned a lot about different RNA-Sequencing analyses to uncover how rare genetic variants interact with each other in a disease context:

[Girirajan Lab @girirajanlab]

Our newest work examines the roles of the variably-expressive 16p12.1 deletion and other rare “second-hit” variants towards gene expression changes and developmental phenotypes using WGS, RNA-Seq of LCL samples, and clinical data from five large families: https://t.co/S49uvmDZ9B