Jessica Hong, MD

Cardiology Fellow @UCSDCardiology | IM @UCLAHealth | MD @UCSFMedicine | @UCBerkeley Alum

[Jessica Hong, MD @JessHongMD]

Strong binders can be too clingy. This Baker lab paper engineers an off-switch for protein interactions.

[Adam Broerman @adam_broerman]

We sought to make proteins both potent and FAST. We used #proteindesign to design precise control over protein interaction lifetimes, enabling us to construct rapid-response circuits, biosensors, and switchable cytokines. Now published @Nature! Links to paper and tutorial below.

[UC San Diego Cardiology Fellows @UCSDCardFellows]

A new #UCSDCardiologyCases from Dr. Jessica Hong (@JessHongMD)! 🏄‍♂️ Young man suffers a VF arrest while surfing. Pulled from the ocean, gets CPR, achieves ROSC. You get this ECG in the ED. What pattern is this, and what's your immediate plan? #CardioTwitter #ECG #FOAMed @UCSDCardiology 1/7

[Harpreet Bhatia @hsbhatia]

What's new with Lp(a)? In this review led by @AlexRazavi, we aimed to summarize the most recent research related to Lp(a), current therapeutic approaches and novel therapies.

@JessHongMD @UCSDCardiology @UCSDCardFellows @FamilyHeartFdn @ASPCardio

https://t.co/tTKVJvflgH

[Jessica Hong, MD @JessHongMD]

Fascinating.

[Martin Picard @MitoPsychoBio]

The brain is full of mitochondria!
But how many, and where?

Different types of mitochondria specialize for energy transformation and other functions

In MitoBrainMap v1.0 we provide the first maps of mitochondrial content and OxPhos capacity across the human brain

[Jessica Hong, MD @JessHongMD]

One man’s trash is another’s treasure! Very interesting concept.

[Samuel Hume @DrSamuelBHume]

Top 5 advances in medicine this week (🧵)

1. An untapped treasure trove of antibiotics

The proteasome breaks down proteins that are no longer needed, but it turns out that some of the peptides it produces are repurposed as antibiotics

The top hit is a peptide derived from a serine/threonine phosphatase

This peptide kills a range of bacteria, including Pseudomonas and E. coli, and stopped mice dying from sepsis just as well as a conventional antibiotic

Study: https://t.co/AJRakhYPPb

Comment: https://t.co/5do8IGdlNm

[Jessica Hong, MD @JessHongMD]

@UCSDCardFellows @UCSDCardiology @ucsdim @UCSDMedSchool @UCSDHealthSci Welcome and congratulations!!! 🎉🍾

[UC San Diego Cardiology Fellows @UCSDCardFellows]

A cath conference gem from our first-year fellow Dr. Jessica Hong @HongJessica_

[Jessica Hong, MD @JessHongMD]

👏 👏 well deserved!

[Mattheus Ramsis @MattRamsisMD]

Thank you @ACCinTouch Accreditation Foundation Board for funding our work of digitally detecting cardiovascular disease using photoplethysmography (#ppg ).

Thank you to my mentors and collaborators for your support in this effort. I look forward to building together and detecting undiagnosed disease in our patient populations.

@PamTaubMD @CALonghurst @tyingwithpolish @UCSDHealth @UCSDCardiology @UCSDMedSchool @InnovationUCSDH @DesignLabUCSD

#digital #ai #earlydetection

[Jessica Hong, MD @JessHongMD]

Amazing capability of nanopore for amino acid sequencing

[Jeff Nivala @jeffnivala]

Published today in @Nature, we describe an approach for single-molecule protein reading on @nanopore arrays. By utilizing ClpX unfoldase to ratchet proteins through a CsgG nanopore, we achieved single-amino-acid sensitivity. https://t.co/ZTFNZkwpcj

[Jessica Hong, MD @JessHongMD]

Cool tech here, imagine the potential applications

[Olivier Schwartz Lab @Virus_Immunity]

Safe and effective in vivo delivery of DNA and RNA using proteolipid vehicles coated with the fusogenic FAST protein: @CellCellPress
https://t.co/YE4EVOKSbs

[Jessica Hong, MD @JessHongMD]

Incredibly exciting to see Dr. Hsue, brilliant physician scientist and woman, at the helm! 🙌🫀

[Department of Medicine at UCLA Health @DOM_UCLA]

Dr. Priscilla Hsue’s welcome reception was a celebration of new opportunities and future achievements. Check out this recap video to see how we welcomed our new chief of cardiology and her exciting vision for the future! #WomenInMedicine #WIMMonth

[UC San Diego Cardiology @UCSDCardiology]

New publication @Nature from Dr. Kevin King and Dr. Van Ninh:

Spatially clustered type I interferon responses at injury borderzones

@EricAdler17 @UCSDCardFellows @UCSDHealthSci

https://t.co/tLyPy3JgYj

[Juan Melero-Martin @MeleroMartinLab]

Our latest @Nature paper is out! We show that transplanting mitochondria into endothelial cells boosts their ability to form blood vessels in ischemic tissues, with mitophagy as the key mechanism. A potential game-changer for vascular cell therapies. https://t.co/ViscFIc9sv

[nature @Nature]

Nature research paper: Temporal dynamics of the multi-omic response to endurance exercise training https://t.co/kQrfmC1cXp

[JAMA Cardiology @JAMACardio]

Sudden ST changes on telemetry prompt a 12-lead ECG for a critically-ill patient who is intubated, sedated, and paralyzed. What would you do next? https://t.co/lVj2L698lG @HongJessica_

[Jessica Hong, MD @JessHongMD]

What would you do next? Your intubated ICU patient develops acute, diffuse ST elevations after neuromuscular blockade. Check out our @JAMACardio case @MCalfonPressMD #ecg #CardioEd https://t.co/ntf9o8Rjcy

[UC San Diego Cardiology @UCSDCardiology]

We are extremely proud to welcome our newly matched general cardiology fellows! Welcome to the @UCSDCardFellows family! @HongJessica_ @EmilyMargolinMD @ROcher_MD @AnnaMcDivitMD @hsbhatia

[Jessica Hong, MD @JessHongMD]

So excited to come home to San Diego for cardiology fellowship!🫀🧬 @UCSDCardiology @UCSDCardFellows

[Nature Biotechnology @NatureBiotech]

Metabolites and RNA in a tissue section are profiled simultaneously https://t.co/UkazybHdDD

[Douglas Yao @DouglasYaoDY]

A general thread on what Perturb-seq is, what it's good for, and how we managed to reduce its cost by an order of magnitude in our recent work: 1/33