Jim 几亩

tsla U btc ethe amzn now

[Jim 几亩 @JimTanaka1]

@beyezuo @laomaobin @Sumerian0 @LD_daofeichang 其实基因检测已非常普及便宜
以有大量数据显示漢人男女跟7000年前的基因完全一致 。
奇怪的反而是蒙满基因参入了外来民族基因或彼此混杂较多。

不要用低劣的意淫替代科学数据

连2022年考古基因数据都颠覆了日本人的意淫他们不是中国人 结果现代日本人跟3000年前原住民基因不同 70%跟漢族基因一致

[Jim 几亩 @JimTanaka1]

@andrewcaravello Andrew, do you still think improving ALC level is not sustainable and did not fix the root cause ?

What is your thoughts on this ?

[Jim 几亩 @JimTanaka1]

@AscendingBio @DrPatrick Which company can do CAR-NK without chemo depletion?

[Jim 几亩 @JimTanaka1]

@andrewcaravello Andrew, what is your thoughts on this CD40 solution? Thanks

https://t.co/50Dnqm6h7t

[Jim 几亩 @JimTanaka1]

@andrewcaravello What is your thoughts on this :

Syena is developing the NY-ESO-1 TCR/IL-15 NK cell immunotherapy. This therapy is based on the scientific discoveries of Dr. Katy Rezvani, at MD Anderson. Syena has an exclusive licensing agreement with MD Anderson for the TCR-NK platform

[Jim 几亩 @JimTanaka1]

@andrewcaravello @JustGodReigns @drpatrick @FDA Should compare

<BCG rechallenge without Antiva > group

vs

< BCG rechallenge with Antiva > group

[Jim 几亩 @JimTanaka1]

@andrewcaravello “Once those T cells are primed, they traffic into every lesion, including the coldest ones, and maintain surveillance for years.”

How does those T cells solve the PD-1 / PD-L1 blocking issue ?

How does it take effect against cold tumor ?

[Jim 几亩 @JimTanaka1]

@andrewcaravello I think the key is how strong and durable the abscopal effects from DCVax vs other cheaper competitors such as:

(1) intratumor injections of molecule tigilanol tiglate (Stelfonta), phase 2a clinical trial (NCT05755113)

(2) Intratumoral oncolytic virus (OV) therapies

etc

[Jim 几亩 @JimTanaka1]

@andrewcaravello Thanks I just read Thomas story, very impressive!

For other cancer types patients have multiple solid mets in the body, Seems like DCVax mainly rely on intratumor injections to treat accessible tumors. Does DCVax injection trigger abscopal effects to kill other remote mets?

[Jim 几亩 @JimTanaka1]

@andrewcaravello “The Phase III trial, which enrolled 331 patients with newly diagnosed GBM, ….with patients treated with DCVax-L living 19.3 ‼️months compared to 16.5 ‼️months for controls “

If DCVax is so powerful, why it only extend patients life 3 months ? What limit its effectiveness?

[Jim 几亩 @JimTanaka1]

@andrewcaravello Native IL-7 is cleared quickly, limiting its therapeutic window

Efficacy depend heavily on the underlying cause of immune deficiency (age, radiation, infection, lymphopenia source, immunosuppressive therapies, etc.). So IL-7 likely won’t “solve all immunodeficiency” by itself.

[Jim 几亩 @JimTanaka1]

@andrewcaravello Because IL-7 broadly stimulates T cells (naïve, memory, effector), there’s a concern that it might also expand unwanted or autoreactive clones (especially in autoimmune-prone individuals). Indeed, IL-7/IL-7R-pathways are implicated in autoimmunity.

[Jim 几亩 @JimTanaka1]

@andrewcaravello But,

IL-7 therapy has Transient effects: In some models (e.g., aged primates), IL-7 therapy increased naïve T cell counts only transiently — often via expansion of existing peripheral T cells rather than renewed thymic output — limiting long-term restoration.

[Jim 几亩 @JimTanaka1]

@andrewcaravello Such lymphopenia most likely contributes to aggressive growth of other Mets in cancer patients body after bone marrow damage from radiation ( some CAR-T immunotherapy also cause lymphopenia) . Any IL-7 based solution for restore immune function, not just ALC number ?

[Jim 几亩 @JimTanaka1]

@andrewcaravello Actually most chemo did not cause persistent low ALC , just cause temporary low neutrophil count. what really cause lymphopenia is radiation therapy when the radiation beam go thru bone and bone marrow which is very sensitive to very low radiation dose. The ALC is hard to recover

[Jim 几亩 @JimTanaka1]

@andrewcaravello @doc_brown2 @NewsNation @drpatrick Cancer patients have no time to wait, both DCVax and Anktiva should be approved by FDA asap for all cancer types. The enemy is FDA and the evil force behind FDA. Cancer needs multiple solutions to work together, mono-therapy never works !

[Jim 几亩 @JimTanaka1]

@andrewcaravello Our so called scientists or science may only know less than 10% how our body immune system works. So as long as the drug is safe and FDA has no reason to restrict dying cancer patients to try it, and let the data and common sense talk.