Jim MacKrell

Scientist/Drug Hunter, Cocktails & Smoked Meat Enthusiast, Natural Born Yinzer, UMich Grad, Husband & Dad. Thoughts=mine alone (or kids if they get the phone)

[Chris Hayduk @ChrisHayduk]

I think this image captures this idea very well. No matter how long you train on RNA & DNA data alone, you will never know protein function & structure. No matter how long you train on protein function & structure alone, you will never know what reaction pathways they participate in.

Need to train across as many modalities as possible to see big gains in performance. But this requires way more data and way more compute because you have to encode across many different tokenization schemes

[Daniel J Drucker @DanielJDrucker]

Now that meaningful #weightloss can be achieved, increasing attention turns to the factors controlling weight regain @NatureRevEndo #obesity https://t.co/BAUDTo0OEi

[Diabetologia @DiabetologiaJnl]

We're excited to announce our 2023 Special Issue: Incretins in Metabolic Disease: Pathophysiology and Therapy. Including 8 reviews summarising up-to-date knowledge on #incretins, from basic biology & treatment modalities to socioeconomic barriers to uptake https://t.co/TyAdMyz3ak

[Dan Michele @MicheleLabUM]

Professor Emeritus John Williams, former chair of @UMPhysiology and previous president of @APSPhysiology, describes his 60 years of experience physiology teaching and mentorship in his recent memoir. https://t.co/5DO2sXHVwt

[Jim MacKrell @JimmyMac_et_al]

@MicheleLabUM @LillyPad @Novartis @AndrewJSchwartz Great thread @MicheleLabUM! It's soo true that @UMPhysiology was a terrific training ground. Always looking for curious and thoughtful scientists to join our teams - so encourage any new grads to reach out to me.

[Jim MacKrell @JimmyMac_et_al]

Who will be the first to highlight selling mackerel and sardines as part of their ESG strategy?

[Nature Reviews Genetics @NatureRevGenet]

Our featured article:
The genetics of obesity: from discovery to biology https://t.co/Fi7W9lDzji #Review by Ruth J. F. Loos & @gilesyeo @Metabolcenter @IcahnMountSinai @MRL_Cam
Free to read here: https://t.co/pvK6Ea7YAk

[Science Magazine @ScienceMagazine]

Metabolism and total energy expenditure change throughout our lives, and now a new study in Science documents a series of distinct, related changes in unprecedented detail.

Learn more ⬇
https://t.co/UjHYyYffbE
#SciencePerspective: https://t.co/aC7yUA7bci

[Cell Metabolism @Cell_Metabolism]

Cardiovascular disease in diabetes, beyond glucose https://t.co/OOdBUjIIjH

[Muthu Vaduganathan @mvaduganathan]

Beautiful #ADA2021 slides illustrating care complexity as kidney disease progresses & major evidence gaps in advanced kidney disease.

Kidney function remains the axis that drives "precision" HF Rx...a critical area of ongoing investigation.

@hvanspall @iebeldhuis @kevin_damman

[The Lancet @TheLancet]

By 2040, chronic kidney disease is estimated to become the fifth leading cause of death globally. In this Seminar, @kamkalantar et al. provide an overview of strategies to preserve kidney function and improve patient outcomes. Read: https://t.co/DCoL2GCzfB

[The Lancet Gastroenterology & Hepatology @LancetGastroHep]

Today is International #NASHDay. Non-alcoholic fatty liver disease affects c30% of the adult population worldwide. It is a multisystem disease requiring a multidisciplinary and holistic approach - read more in this recent Review by Targher et al:
https://t.co/fC0JvA3H0c #NAFLD

[Dennis X. Hu @DennisWhom]

2020 Small Molecule Drug Approvals - https://t.co/KX2LOZM8FK

Drug Hunter subscribers can download the full list w/ mechanism of action, route of admin., pivotal trial NCTs, primary endpoints, enrollment at time of approval, etc.

#chemtwitter #biotwitter #medtwitter

[Ali Aminian @Ali_Aminian_MD]

✅ 5-Year Impact of Metabolic Surgery on Quality of Life in Patients with #Obesity & #Diabetes

Surgical Patients Reported:
⬆️Energy
⬇️Fatigue
⬇️Pain
⬆️Physical Functioning
⬆️General Health Perception

Findings are presented today at #AmerSurg21 #ASA2021
https://t.co/oiXPhLhwSg

[Dr. David Ludwig @davidludwigmd]

Insulin was discovered in 1921.

Previously, a low-carb diet was the mainstay of treatment for all types of diabetes.

Afterwards, high-carb diets became popular, but not because of evidence of superiority

👉Time to rediscover centuries-old wisdom on diet https://t.co/5sLCVbT6ao

[JACC Journals @JACCJournals]

Should we focus on earlier-in-life LDL reductions? New #JACC research suggests cumulative exposure might be an important target: https://t.co/HDhTZl6N5u #CVD #cvPrev

[Ethan J. Weiss @ethanjweiss]

19/ We enrolled/compeletd this trial quickly (about a year) with the incredibly hard work of Dylan and the study team

This morning the paper is finally published! https://t.co/Qzsm3OKIIm

[David Bishop (🦋 also bluespotscience.bsky.social) @BlueSpotScience]

Excited to have collaborated with my twitter-free colleagues Graham Hollway & Amanda Genders on this review: "Are alterations in skeletal muscle mitochondria a cause or consequence of insulin resistance?", which has just been accepted.

[Javier Torres @JTLLERGO]

⚠️Excelent Review:
‼️Altered Hemodynamics and End-Organ Damage in Heart Failure.
📍Impact on the Lung and Kidney
via @CircAHA @secardiologia @SACardiologia @clinica_sec @SIAC_cardio
https://t.co/0fj3Yyunan

[Nature Reviews Endocrinology @NatureRevEndo]

New content online: Role of fructose in NASH defined https://t.co/qQK7i0K04N