How do bacteria build their flagella?
We’ve put together an animation of Salmonella flagellum assembly based on cryo-EM and X-ray structures.
From the membrane-embedded machinery to the growing filament, here’s how the parts come together, step-by-step.
Read the #FirstDisclosure featured on the cover of the October issue ➡️ ABL209 (NEOK002): Designing an EGFR × MUC1 Bispecific TOP1i ADC with Promising Antitumor Activity and Enhanced Therapeutic Window https://t.co/Bc2ApUMrJD @JinwonScience@ablbioinc#OpenAccess
I am delighted to be recognized as a member of the World ADC Honor Society.
Looking forward to reconnecting with peers, exchanging ideas, and continuing to drive innovation across the ADC field at World ADC San Diego.
https://t.co/ORb69VJdTu
안녕하세요, 저희 초6 어린이가 조별 과제로 skyscrapers라는 기존 숫자 퍼즐 게임의 난이도를 측정하는 것을 하게 됐어요. codex로 본인이 만든 ChatGPT Sites입니다. 실제 플레이 시간을 수집해 그 데이터를 분석하려고 합니다. 트친님들의 참여가 필요합니다! https://t.co/JfM63lcPri
Among infants with a family history of allergy, a maternal diet high in eggs and peanuts during pregnancy and lactation did not result in a lower risk of egg or peanut allergy at 1 year than a standard diet. Full PrEggNut trial results and Research Summary: https://t.co/rsF250SBfZ
My team has published a new paper :
Preclinical development of ABL206, a novel bispecific antibody-drug conjugate targeting B7-H3 and ROR1
https://t.co/tJ5HodsDic
ABL206 is in phase 1 clinical trial (NCT07612176)
From #ASCO26: a Portuguese real-world study in patients with HER2-low breast cancer, adding to the growing body of literature on "ADC after ADC" with similar payloads!
(Original data on the top, digitalized and re-plotted by patients on the bottom for better visualization!)
Yet another study shows a 24% reduced risk of dementia after the Shingles vaccine. This one in over 500,000 participants with a recent skilled nursing facility stay, adding to 4 huge natural experiments in 4 countries (US, Canada, Wales, and Australia)
https://t.co/TmYqwTB7IT @AnnalsofIM
Last year, we reported that KRAS+PRMT5 is synergistic in MTAP-null PDAC (https://t.co/mIc6hkbMpL). Today, the first clinical data for a KRAS/PRMT5 combination was reported, with an incredible 92% ORR.
RAS inhibitors are the present, but combinations are the future!!
$TNGX $RVMD
Congratulations to all investigators and patients involved in Phase 3 G-HOPE-001. Arcotatug tavatecan (IBI343/TAK-921), an Fc-silenced CLDN18.2 ADC vs 3rdline chemo, met PFS endpoint at the first interim analysis. Looking forward to sharing full results. https://t.co/F3DvIy3Mji
ABL Bio developed, and NEOK Bio has initiated U.S. Phase 1 clinical trials for the bispecific ADC candidates ABL206 (NEOK001) and ABL209 (NEOK002), with the first patient dosing now successfully completed.
https://t.co/p8YU33PYPo
Big paper coming out soon.
Using AI, we mapped embryos of mice, alligators, turtles, rhesus macaques, and chickens in 3D and at single-cell resolution.
We discovered something truly remarkable...stay tuned!