Joe Harman

[Tom Milne @milnetom68]

It is fantastic to finally be able to see this paper in print, great collaboration with everyone:

https://t.co/8uYefyX6gf

MLL-AF4 creates high density enhancer interactions by recruiting a transcription complex including FACT and PAF

[Fabian Theis @fabian_theis]

Glad to see our review on best practices for single-cell analysis across modalities out @NatureRevGenet! In a big team effort led by @LukasHeumos & @AnnaCSchaar, we recommend workflows based on benchmarks. Paper at https://t.co/dN1jwlmIZA & extension at https://t.co/NVurPpJaHH.

[Tom Milne @milnetom68]

Our newest paper with many great collaborators including @andiroy and @SiobhanRice12 : PAF1 and FACT cooperate with MLL-AF4 to drive enhancer activity in leukemia https://t.co/IYewTfDcIr

[andi roy @andiroy]

This paper is rather special. Thanks everyone (funders, reviewers, collaborators) who believed it could be done, the fabulously talented first author @SiobhanRice12 for her hard work and co-senior authors @milnetom68 & IreneRoberts for unfailing support https://t.co/qU4Yih8pnL

[Siobhan Rice, PhD @SiobhanRice12]

Our article describing a new faithful model of MLL-AF4 infant ALL is out today🎉Thanks to co-authors, funders, and patients/their faimilies for helping make this a reality! Hopefully this will be a powerful model to help understand this aggressive disease
https://t.co/ZXzEmv5kEQ

[Tim Sainburg @tim_sainburg]

There's a new preprint calling to stop using UMAP, t-SNE et al, calling them arbitrary "Specious Art", which I disagree with. It's getting a lot of attention, and I think I have an idea why.

[Marieke Oudelaar @MariekeOudelaar]

📣Happy to share the first preprint of our team at @mpi_bpc in collaboration with @jdavieslab: Analysis of sub-kilobase chromatin topology reveals nano-scale regulatory interactions with variable dependence on cohesin and CTCF. https://t.co/zLsLGxzYkp #3Dgenome #generegulation 👇

[Tom Milne @milnetom68]

In our most recent accepted paper, we use a model network to connect an oncogenic driver mutation with indirect targets, and make predictions about transcription factor interactions. Great job Joe and team! https://t.co/DnZ9ed12wo

[Tom Milne @milnetom68]

Fantastic job Joe and Ross and thanks to all our amazing collaborators @TFulga @andiroy @UKsynbio @MRC_WIMM

Phenotypic analysis of an MLL-AF4 gene regulatory network reveals indirect CASP9 repression as a mode of inducing apoptosis resistance. https://t.co/xELrYrWbin

[Tom Milne @milnetom68]

Our new paper, where we construct an MLL-AF4 gene regulatory network and show how it regulates apoptotic pathways

Phenotypic analysis of an MLL-AF4 gene regulatory network reveals indirect CASP9 repression as a mode of inducing apoptosis resistance. https://t.co/xELrYrWbin