jdavieslab

Davies lab @MRC_WIMM @UniofOxford

[Biomedical Picture of the Day BPoD @BPoD_s]

Mapping chromatin's structure at base-pair resolution reveals how it mediates cis-regulatory element interactions

📹 @hangpengli578 et al @jdavieslab @MRC_MHU @MRC_WIMM @UniofOxford in @CellCellPress
➡️ https://t.co/xzcw8v3NjO

[James Davies @jojdavies]

Our latest paper has just been published in Cell!

https://t.co/5iAl1EaGEJ

We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.

[Nucleome Therapeutics @NucleomeTx]

Delighted that Nucleome is showcased as one of the 50 companies in @PwC_UK’s 'Life Sciences Future 50' report, illustrating the world-class science and innovation being led by the UK’s life sciences sector.

Read the report here: https://t.co/wHntsDAkeZ

[James Davies @jojdavies]

We are looking for an RA to join the lab to work on a fantastic genomics project!

https://t.co/mSBLNhGCp1

Closing date next week!

Please RT - thank you!

[deWitLab @deWitLab]

Very exited to share that our work showing the importance of SOX2 pioneer activity for gene activation has now been published in @embojournal. Excellent work from @michelamaresca and @TeunvandenBrand. And a nice collaboration with @jojdavies (+lab). https://t.co/TzsTjuoQxB

[Li-Hsin Chang @Lihsin0507]

Very happy and honored to present our work from my postdoc project in @DaanNoordermeer lab @I2BCParisSaclay on CTCF clustering at TAD boundaries and the novel multi-contact 3C assay: Nano-C – now published @NatureComms.

https://t.co/6l1d6ID0PL.

A nice 🧵 written by Daan 👇

[paresh vyas @pvyas_oxford]

Delighted to share our new approach for high fidelity sc genotyping combined with scATAC - called GTAC! Do check it out! We love it. Great collaboration with the Hughes and Davies labs also in the WIMM. Credit to Sven, Asger, Angus and all co-authors.

https://t.co/E1k25E6kOM

[Knight Genetics @KnightGenetics]

We are excited to share our recent work mapping the host response to sepsis at single-cell resolution. The study, led by @andrewjkwok and published in @NatImmunol, identifies a subset of immature neutrophils which is increased in severe sepsis.

Big thanks to everyone involved!

[Adam Mead @AdamMead_Oxford]

The Clinicogenomic Landscape of Induction Failure in Childhood and Young Adult T-Cell Acute Lymphoblastic Leukemia https://t.co/z47JVrWcx3

TAL1 non coding mutations predict induction failure and poor outcome in T-ALL.

Terrific work from @Marcrmansour and colleagues.

[Josu de la Fuente @josudelafuente]

#efficacy #genome #editing exa-cel @VertexPharma leading to abrogation disease manifestations most #patients #thalassaemia & #sicklecell #EBMT2023 @TheEBMT #presidential; @ImperialNHS @ImperialImmuno part of this work

[James Davies @jojdavies]

In 2016 I looked after a girl who died during a transplant for HbE beta-thalassaemia.
I am overwhelmingly pleased that we have been able to correct HbE with near 100% efficiency using base editors.
https://t.co/LIVpGvJPhR
Brilliant work from Mohsin Badat @Montytrench @jdavieslab

[Joseph Hamley @josephhamley98]

Really pleased to see our @NatureProtocols paper out this week. We have put together a comprehensive guide to generating base resolution 3C data!

@hangpengli578 @jojdavies @jdavieslab

[jdavieslab @jdavieslab]

Congratulations @josephhamley98 and @hangpengli578 for putting together a nature protocols paper for Micro Capture-C! https://t.co/fszNgx67c3

[Josu de la Fuente @josudelafuente]

@jojdavies @TheEBMT

[Mark Dawson @MAF_Dawson]

Cofactor requirements for transcription factors! A labour of love for @charles_bell92 - so very proud of him and all in @TheDawsonLab involved. A body of work that is not only amazing in scale but also tackles an important and tough question in our field - Enjoy!

[Sven Turkalj, PhD @SvenTurkalj]

Delighted and honoured to receive the ASH Abstracts Achievement Award for our oral presentation at this year's @ASH_hematology meeting! Very grateful for the mentorship @pvyas_oxford and to my fantastic colleagues at the @MRC_WIMM. This was a true team effort! #ASH22

[James Davies @jojdavies]

Delighted to have you joining the lab!

[MRC MHU @MRC_MHU]

Only ~2% of the human genome codes for proteins.

A @wellcometrust Discovery award for @jrmmhughes @jdavieslab and @ceclindgren aims to deepen our understanding of the other 98% and its role in disease.

@bdi_oxford @MRC_WIMM

Music: MNDLSS

[MRC WIMM @MRC_WIMM]

A new @wellcometrust Discovery award project aims to use Micro Capture-C and Deep Neural Network Machine Learning to decipher the role of the non-coding genome in disease.

@jrmmhughes. @jdavieslab @MRC_MHU
@ceclindgren @bdi_oxford

https://t.co/5sPA3BpVD3

[James Davies @jojdavies]

Really excited to work on this project with @ceclindgren and @jrmmhughes! @wellcometrust https://t.co/puU4yhqAt3