Knight Genetics

Official account of Prof. Julian Knight's lab at @NDMOxford @OxfordMedSci and @HumanGeneticsOx

Using functional genomics to understand the human immune system

[Knight Genetics @KnightGenetics]

Some of the big questions raised by the COVID-19 pandemic are 'Why do we all have such a different reaction to the infection? From the mild cases to the seriously sick?'

Our #COMBAT paper in @CellCellPress aims to explore these questions

A 🧵by Dr Justin Whalley & @DrCarlaCohen

[Knight Genetics @KnightGenetics]

Our new study shows a genetic variant fine-tunes MTOR and immune crosstalk, improving survival in pneumonia-associated #sepsis - toward personalised treatments.
Congrats to @pingzhangneho and everyone involved! @HumanGeneticsOx @CAMS_COI_Ox @NatureComms
https://t.co/AYRbaq505i

[Ping Zhang @pingzhangneho]

Glad to share our study showing how a common genetic variant impacts immune cell-cell communication and patient survival in pneumonia-associated sepsis, providing a framework for stratified therapy. Thanks to our funders and everyone involved.
https://t.co/fTxAxolGOr

[Cell Genomics @CellGenomics]

Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis https://t.co/mZfr8edJah

[Knight Genetics @KnightGenetics]

Our research on the chromatin landscape of ankylosing spondylitis (AS) has just been published in @CellGenomics. An important step towards future drug discovery.

Congratulations to @DrCarlaCohen, @HumanGeneticsOx, and and everyone involved!

[Carla Cohen @DrCarlaCohen]

Really excited to present our research on epigenomics of #AnkylosingSpondylitis, a spinal arthritis.

Published this week in @CellGenomics: https://t.co/6rBopMETVx

1st authors: Andrew Brown, Ola Mielczarek, Gabriele Migliorini and @DrCarlaCohen

A 🧵

[Knight Genetics @KnightGenetics]

We are excited to share our recent work mapping the host response to sepsis at single-cell resolution. The study, led by @andrewjkwok and published in @NatImmunol, identifies a subset of immature neutrophils which is increased in severe sepsis.

Big thanks to everyone involved!

[Nature Immunology @NatImmunol]

Julian Knight and colleagues find that altered granulopoiesis and increases in immature immunosuppressive neutrophil subsets are associated with poor outcomes in some patients with sepsis. Read it here: https://t.co/8K3YkYYeqX

https://t.co/mBs4CSNusY

[Carla Cohen @DrCarlaCohen]

Congratulations to @KnightGenetics @andrewjkwok @eddiecg and team for their work on immune subsets in sepsis

[Carla Cohen @DrCarlaCohen]

Our study on AS epigenomics has been covered by @GenomeWeb

Watch this space for link to paper and 🧵

[Knight Genetics @KnightGenetics]

A big thank you to the patients, families, clinicians, and research nurses involved in our sepsis studies, without whom this wouldn't have been possible.

Congratulations to @eddiecg @ee_davenport @HumanGeneticsOx @sangerinstitute and everyone else involved!

[Knight Genetics @KnightGenetics]

We are excited to share our new study, out now in @ScienceTM!

We developed a machine learning framework (SepstratifieR) to stratify infection patients by risk of severe illness.

SepstratifieR is publicly available and applicable to sepsis, influenza and COVID-19.

🧵👇 (1/15)

[Knight Genetics @KnightGenetics]

For more information, you can refer to our full publication and the associated R package:

R package: https://t.co/S1ozgqSsI8
Publication: https://t.co/iFI7bawSQh

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