Jorge Luis Olivares Camacho

Difusión de ciencia, tecnología, arte. Escritor de libros de Ortopedia, Columna Vertebral, Neuro-Ortopedia, Cirujano Ortopedista.

[J Bone & Joint Surg @jbjs]

"Risk Factors Associated With Nonunion Following Periacetabular Osteotomy for Treatment of Symptomatic Hip Dysplasia" by Beyer et al.

Read online at: https://t.co/dnuoSWbABX

[Martin Picard @MitoPsychoBio]

@doctorinigo Looks like a classic expression of the Energy Resistance Principle?

Sedentarity decreases electron flux in mitochondria, which then decrease electron import via the MPC as a protection mechanism.

https://t.co/SYDZJinZBe

[Jorge Luis Olivares Camacho @JorgeLOC1960]

@doctorinigo A great article by Dr. Iñigo San Millán @doctorinigo and his group. Thanks for sharing.

[Iñigo San Millán @doctorinigo]

🚨 🔬RIGHT OUT OF THE OVEN!. Our last study published today!.

Even in apparently healthy people, sedentarism was associated with a major impairment in mitochondrial function.

We used skeletal muscle biopsies, high-resolution mitochondrial respirometry, metabolomics, proteomics, targeted mitochondrial lipidomics including cardiolipin analysis, ROS assessment and ¹³C tracer-based oxidation flux analyses to examine how sedentarism affects mitochondrial function, substrate oxidation and cellular fuel metabolism.

1) One of the key findings was an almost 50% reduction in MPC1 (the mitochondrial pyruvate carrier) that allows pyruvate to enter the mitochondria and be oxidized.

Our data suggests that glucose dysregulation could happen at the mitochondrial level, years before insulin resistance happens at the surface level, leading to type 2 diabetes. I call this an "inside-out" theory of glucose dysregulation.

2) The second important finding is that we can also correlate the mitochondrial dysfunction, metabolic flexibility and decrease in MPC1 with cardiopulmonary exercise testing (CPET) plus lactate testing, which I call "CPELT" -cardiopulmonary exercise lactate testing. With this test we could indirectly assess in a non-invasive way, mitochondrial dysfunction in healthy people years before metabolic disease shows up and intervene with specific exercise prescription and nutrition.

Link to the study here!👇
https://t.co/338KE6plE5

#Mitochondria #MetabolicHealth #PhysicalActivity #Sedentarism #MPC1 #Metabolism #Healthspan #Longevity #DiabetesPrevention #HealthyAging

[Arthrex MedEd @ArthrexMedEd]

In today's #WhatsNewAtArthrex, Aaron J. Krych, MD, demonstrates all-onlay medial patellofemoral ligament (MPFL) and medial quadriceps tendon femoral ligament (MQTFL) reconstruction techniques using the MPFL Reconstruction Kit with hybrid Knee FiberTak® anchors.

Learn more: https://t.co/nfgpbIOJ7r

[UpSurgeOn @upsurgeon]

BIG NEWS! SPINE DEFORMITY: NOW WITH REAL-TIME TELEMETRY 📡

Probably one of the most advanced technologies ever launched by UpSurgeOn.

🚀 Spine Deformity enters a new dimension of surgical training:
Train with purpose.
Measure your performance.
Compete. Improve. Repeat.
#spine

[Arthrex MedEd @ArthrexMedEd]

The MIS FiberTak® Achilles SpeedBridge™ system uses a percutaneous approach for the treatment of insertional Achilles pathology.

Visit #Arthrex at Exhibit 203 during #AOSSM2026 to learn more about our latest innovations: https://t.co/m9HpEOH4w0

#FootAnkle #Achilles #AOSSM

[Michael T. Lawton, MD @mtlawton]

Transventricular surgery is a combination of subarachnoid dissection thru tight cisterns like interhemispheric fissure + open waters like lateral ventricles, arriving at the deepest of targets w/hardly any brain transgression. Here, some transchoroidal work was needed to reach anteromedial pulvinar from above as fornix bent laterally on its course to atrium…

[Arthrex MedEd @ArthrexMedEd]

The Arthrex Foot and Ankle Surgeons (DPM) Symposium gave healthcare professionals experience with the latest #Arthrex product innovations through didactic sessions, live demonstrations, and hands-on practice in the ArthroLab™. Topics included lateral ankle instability, insertional and midsubstance achilles, flatfoot, and TTC fusion/DualCompression nail.

View our upcoming medical education courses: https://t.co/EmfK5uqh47

Faculty:

Hummira Abawi, DPM; Michael W. Downey, DPM; Steven Douthett, DPM; Matthew D. Doyle, DPM; Alan A. MacGill, DPM; Joseph Park, DPM; Noman A. Siddiqui, DPM

#FootandAnkle #DPM #MedicalEducation

[Astronomy Vibes @AstronomyVibes]

The electron’s minimum lifespan is 5 quintillion times longer than the current age of the cosmos.

Electrons are the ultimate survivors of the subatomic world, boasting a minimum lifespan of 66,000 yottayears—a duration so vast it effectively defies human comprehension.

To put that into perspective, these fundamental particles are expected to outlast the current age of the universe by a factor of five quintillion. While humanity measures history in centuries, electrons operate on a scale that makes the 13.8 billion years since the Big Bang look like a mere blink of an eye.

This extreme longevity is the bedrock of physical reality, ensuring that the atoms forming our world remain stable and intact across cosmic eons.

The secret to this relative immortality lies in the fundamental laws of physics, specifically the conservation of electrical charge.

Because the electron is the lightest particle with a negative charge, it has no lower state to decay into without violating core physical principles. High-precision experiments, such as those conducted with the Borexino detector, have failed to witness a single electron perish, leading many physicists to believe they may be perfectly stable and live forever. This cosmic endurance guarantees that as long as these laws hold, the building blocks of matter will provide a permanent, unchanging foundation for the universe as we know it.

source: BBC Science Focus Magazine. (2025). How long do electrons live? BBC Science Focus Magazine.

[Mathelirium @mathelirium]

The Non-Traversable Bridge Einstein Found Inside Gravity

Einstein’s equations not only describe gravity as a force but as the shape of Spacetime as well.

In 1935, Einstein and Rosen found that the Schwarzschild solution could be written in a way that reveals something astonishing:

Two separate exterior regions of Spacetime joined by a bridge-like throat

Rᵤᵥ = 0

This became known as the Einstein-Rosen Bridge.

It is often called a Wormhole, but the classical Einstein-Rosen bridge is not a science-fiction tunnel. In the standard Schwarzschild geometry, it is non-traversable. The throat does not remain open long enough for ordinary travel from one region to the other.

Its real power is mathematical.

It shows that General Relativity is not merely about objects moving through space. The theory allows Spacetime to have global structure such as different regions, horizons, extensions, and hidden connections that are not visible from one local patch alone.

The Einstein-Rosen bridge is one of the earliest glimpses of that deeper idea.

Gravity is geometry.

And sometimes, geometry has two worlds joined by a throat.

#Astrophysics #GeneralRelativity #Einstein #BlackHole #Spacetime #Cosmology #Gravity #Wormhole #Mathematics #Physics

[JAMA @JAMA_current]

#GastricCancer develops in the stomach and is diagnosed at an average age of 68 years in the US.

📝 This JAMA Patient Page describes risk factors for gastric cancer, ways to prevent it, and the treatment and prognosis.

https://t.co/7i9O9b1fAl

[Hubble @NASAHubble]

With Hubble, astronomers have learned to expect the unexpected in our universe.

A new discovery shows why: Hubble detected ultraviolet light escaping from a galaxy that existed just 1.4 billion years after the big bang.

Learn more: https://t.co/7cRjmeFkeL

[News from Science @NewsfromScience]

Like a stadium full of sports fans doing the wave, neurons coordinate their electrical signals in rhythmic patterns that sweep across the cortex, the brain’s outermost layer.

Recent studies in humans and animals have shown these patterns, called traveling waves, can take on complex shapes, among them a rotating spiral that has been observed during deep sleep, memory retrieval, and other brain processes.

A new study has now captured the fast-spinning waves spanning whole brains, offering clues to how they’re organized and what they might do.

Learn more: https://t.co/gAK0mjsUyL

[Cell Press @CellPressNews]

Spontaneous and conversational laughs come from two different parts of the brain.

Learn more in Trends in Neurosciences: https://t.co/aesQlabGei

Fausto Caruana & Sophie K. Scott

[J Bone & Joint Surg @jbjs]

"Open Reduction and Internal Fixation of Femoral Head Fracture After Firearm Injury" Mehta et al.

Read online at: https://t.co/2xQ3Evu33A

[Jorge Luis Olivares Camacho @JorgeLOC1960]

@TDekkersPhysio Okay, even a little supervised muscle strengthening during this time can improve the patient.

[Thomas Dekkers | Spinal Specialist Physiotherapist @TDekkersPhysio]

👉Clinical Implication 2: Always be ready to refer on, but a large disc herniation does not mean an automatic referral.

If the patient has no motor or caudal equina signs and pain is well managed, a wait-and-see approach with careful rehab may be best option.

See this recent🧵 for full details: https://t.co/j8K53PriMm

[Thomas Dekkers | Spinal Specialist Physiotherapist @TDekkersPhysio]

👉Clinical implication 1: an MRI is a snapshot, not a prognosis.
Imaging and symptoms decouple over time.
Although resorption does occur in many, some may continue to have persistent pain.
I see many neuropathic pain presentations with a relatively normal scan, who preciously had a large disc herniation .