Joseph Capani

B.S. in chemistry, Brown University - 2018
Ph.D. Candidate at UC Irvine
Member of @thevanderwallab
Linkedin:

[J. Am. Chem. Soc. @J_A_C_S]

📈 One of our most read articles in the last 30 days describes the evolution of a successful strategy for the synthesis of the strained, cage-like antiviral diterpenoids wickerols A and B.

Read the open access article in full to find out more ➡️ https://t.co/nthhKtxKsu

[Vanderwal Lab @thevanderwallab]

Great turnout at Overman Symposium this past Saturday! @JosephCapaniJr and @njmattfurry enjoyed this opportunity to showcase some exciting results building on work we disclosed in @J_A_C_S earlier this year: https://t.co/5R6N3Zxhfo

[Joseph Capani @JosephCapaniJr]

@profjasti @thevanderwallab @J_A_C_S Thank you! It made for an interesting reaction optimization campaign.

[Vanderwal Lab @thevanderwallab]

Our enantioselective syntheses of Wickerols A & B is out now in @J_A_C_S! Several generations of group members moved mountains to make this possible: @Jonatha17807916, @JosephCapaniJr, Matthias Göhl, and Philipp Roosen - congratulations! Get the scoop at:
https://t.co/5R6N3Zxhfo

[Vanderwal Lab @thevanderwallab]

You know that feeling when you see a proposed biosynthesis that makes you feel a little uneasy? We're right there with you. Our investigation tackling the biogenesis of alstonlarsine A is out now in @angew_chem - congratulations Griffin and Allen!
https://t.co/FjVZe8H1sw

[Joseph Capani @JosephCapaniJr]

@NickMilo Hi Nick! I'm enjoying the LYT kit and I think it's awesome that you made such a powerful tool/template for PKM freely available. Having spent 3 months building my own system, I like to open both vaults side by side and cross-pollinate features that make sense for me.

[Joseph Capani @JosephCapaniJr]

@VictorKiryak D. Deprotonation of carboxylic acid, followed by lactonization by intramolecular nucleophilic displacement (facile?) Addition elimination gives the ethyl ketone product, opening the lactone, then another addition of Grignard into the ketone gives the corresponding diol.

[Total Synthesis @TotalSynthesis]

A Concise Enantioselective Approach to Quassinoids by William P. Thomas and Sergey V. Pronin at @UCIChemistry in @J_A_C_S https://t.co/gX1ruK5RGp

[Total Synthesis @TotalSynthesis]

Evolution of a Short and Stereocontrolled Synthesis of (+)-7,20-Diisocyanoadociane by Philipp C. Roosen, Alexander S. Karns, Bryan D. Ellis, and Christopher D. Vanderwal @thevanderwallab at @UCIChemistry in @JOC_OL https://t.co/jJkbgqjAy2

[Vanderwal Lab @thevanderwallab]

Out now in @JOC_OL ASAPs! Stereocontrolled Synthesis and Structural Revision of Plebeianiol A https://t.co/mT3cDTIZHR
Congratulations Lucas, Scott, and Darius!

[Vanderwal Lab @thevanderwallab]

Hot off the press in @JOC_OL! Soft Enolization of 3‑Substituted Cycloalkanones Exhibits Significantly Improved Regiocontrol vs Hard Enolization Conditions https://t.co/XWk11W1ADt
Congratulations @nataliedwulet and Vincenzo!