Josh Griffiths

Renal SpR and MRC/KRUK Clinical Research Training Fellow in Renal Medicine at the University of Sheffield. ADPKD genetics. Man City FC

[AJKD @AJKDonline]

Monoallelic IFT140 Variants Causing Childhood-Onset Autosomal Dominant Polycystic Kidney Disease

https://t.co/eXlRAtcFhh

@JoshDGriffiths @CamyLG86

[Josh Griffiths @JoshDGriffiths]

@Dr_R_Walker @Kidney_Research Congratulations!!

[NEJM @NEJM]

In this trial involving patients with chronic kidney disease, empagliflozin resulted in a lower risk of disease progression or death from cardiovascular causes than placebo. #KidneyWk https://t.co/HFgzPgrRFx

[KidneyGeneticsGroup @Ong_Lab]

Delighted to share our recent publication.

A founder UMOD variant is a common cause of hereditary nephropathy in the British population.

Thank you to all who helped with this work!

@mkvalluru

https://t.co/wgnQz4ThbP

[Alan Yu🇭🇰 @AlanYuNeph]

Back from fabulous @FASEBorg #PKD22 mtg & finally had time to gather my thoughts. What's🔥🔥🔥in PKD? Here are the headlines👇
🧵

[Kidney Research UK @Kidney_Research]

The second project funded as part of our partnership with @PKDCharity is that of Professor Albert Ong.

Professor Ong is on a mission to discover and test new treatments for ADPKD, building on some of his existing work in the area.

Read more 👇
https://t.co/hVG2hpfWe6

[Josh Griffiths @JoshDGriffiths]

@Kidney_Research @sheffielduni Congratulations! @Ong_Lab

[Kidney Research UK @Kidney_Research]

Congratulations to Professor Albert Ong of @sheffielduni for winning the 2022 Lillian Jean Kaplan International Prize for Advancement in the Understanding of Polycystic Kidney Disease (PKD) - an amazing achievement.
https://t.co/DWzKrsFS9O

[PKD Research Resource Consortium @PkdResearch]

Congratulations to Dr. Alessandra Boletta and Dr. Albert Ong for being the recipients of the Lillian Jean Kaplan International Prize honoring individuals for excellence and leadership in PKD clinical and basic research. #endPKD #PolycysticKidneyDisease

[Josh Griffiths @JoshDGriffiths]

Delighted to have been offered this fellowship. Excited to start! @Ong_Lab

[Kidney Research UK @Kidney_Research]

Research in focus 🔍

With our funding, Dr Joshua Griffiths from @sheffielduni will try to understand how the stiffness of the skeleton of cells affects cyst growth in patients with ADPKD - a leading cause of kidney failure.

Read more 👉 https://t.co/CEQQ3NTfha.

[@CKD_ce @ckd_ce]

1) Welcome to this #accredited #tweetorial on #cardiovascular disorders in Autosomal Dominant Polycystic Kidney Disease. #ADPKD is widely recognized in assoc w/risk of #CKD, but has protean #cardiovascular effects as well. Expert author @dguerrot of @CHURouen 🇫🇷 leads us!

[JASN_News @JASN_News]

Inducible disruption of cilia-related genes in mice results in slowly progressive cystic disease, which is accelerated by renal injury. This study shows that adaptive immune cell subtypes contribute to injury-accelerated cystic kidney disease in mice https://t.co/VREkxpoHk2

[Josh Griffiths @JoshDGriffiths]

@RenalDocGillis @SheffieldHosp Congratulations! Very well deserved!

[Josh Griffiths @JoshDGriffiths]

Absolutely delighted to be offered this KRUK/MRC clinical training fellowship! I'll be exploring why cysts develop and novel therapeutics in ADPKD. Can't wait to get started! @Ong_Lab #ADPKD @PKDCharity @The_MRC

[Kidney Research UK @Kidney_Research]

New research grants awarded 🗞️

After another difficult year, we are delighted to have been able to still award grants for new research that will contribute in the fight to end kidney disease.

More information below 👇 https://t.co/zaeAsKivCv

[Josh Griffiths @JoshDGriffiths]

@ElRagada Thank you!

[Kidney Research UK @Kidney_Research]

And our photo competition winner is...
Dr Laura Wilson's stunning image of macrophages (purple), kidney tubules (green) and lymphatic vessels (white) in a developing kidney🏆
📸‘More than just tubules – the importance of the immune system in growing a kidney’.
#KidneySnapshots

[KidneyGeneticsGroup @Ong_Lab]

Excellent collection of reviews in a special edition of Cellular Signalling on many aspects of ADPKD (including some from members of our own group!)

Complimentary access for a limited time so get them while you can! 😉 #pkd #KidneyDisease

https://t.co/6SFhIcPDEr

[KidneyGeneticsGroup @Ong_Lab]

We are delighted to share our latest publication!

We report on a novel interaction between PC1 and the specific RhoGAP proteins (ARHGAP35) in the regulation of Centrosomal RhoA activation and ROCK signalling.

https://t.co/QE4eo8k9nv

[NEJM @NEJM]

Correspondence — Retraction: Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19. N Engl J Med. DOI: 10.1056/NEJMoa2007621. https://t.co/6NVZ4mqIJA

[KidneyGeneticsGroup @Ong_Lab]

Our new pre-print is out!
Along with our collaborators at @ImperialImmuno @UHN , we identify a subset of urinary exosomal miRNAs that could serve as novel biomarkers of disease progression and suggest new therapeutic targets in ADPKD.
Thanks everyone!

https://t.co/7Mmmrd9I1q