Justin Pritchard

The Pritchard Lab at Penn State.
We use modeling and experiments to study drug resistance.

[Samuel Hume @DrSamuelBHume]

This is an interesting idea: turning a cancer's drug resistance against it

These are growth curves of tumours in mice, treated with a drug (a tyrosine kinase inhibitor). The tumours initially shrink but they all - slowly but surely - become resistant:
This study aimed to convert this resistance into vulnerability, by supplying tumours with a plasmid that deliberately provides resistance to the drug - but also encodes a suicide gene

What this means is that tumours shrink initially as they're treated with the tyrosine kinase inhibitor, but then grow back - fast - as they start to express the resistance gene

This expands the pool of resistant cells, but also the pool of cells with the suicide gene - so when the suicide gene is switched on (purple arrow), the tumours regress:
Leighow et al: https://t.co/utMgZvB7gx

[Scott Leighow @ScottLeighow]

Additionally, we find that our platform can effectively redesign tumors in vivo, enabling the elimination of cancers otherwise destined for treatment failure.

[Scott Leighow @ScottLeighow]

As our understanding of the molecular basis of cancer improves, so does our ability to build targeted drugs that exploit cancer's genetic vulnerabilities to safely and potently kill tumor cells.

[Justin Pritchard @JustinPritcha19]

@kristen_naegle @UVADeanJWest @UVABME Congrats Kristen!!!!!!!!!

[nature @Nature]

Astronomer Cecilia Payne-Gaposchkin missed out on recognition despite her brilliance; a 2020 biography sets her in the firmament. https://t.co/0nLNmkwvEd

[Justin Pritchard @JustinPritcha19]

@NiTriona Thanks ! We are excited about these gene sets, and are using them a lot in our lab now. I’m getting a tweetorial together!

[Howie Weiss @hweiss3]

Good exposition of Bayes’ law applied to high false positive rate in genetic testing for rare diseases

https://t.co/H13n6Ubdz2

[Yannis Zervantonakis @zervanto]

Our paper on mechanical stress-induced tumor cell migration and proteomic analysis (p38MAPK/JNK/cdc42/Rac1 axis) with
@TriantafyllosS4 lab and Gordon Mills lab has been published on @MCR_AACR. Open access here: https://t.co/2TVEioXCOA Wonderful work by Maria and Rosy.

[Coulter BME | Emory & Georgia Tech @CoulterBME]

Congratulations to Manu Platt @DrPlattLab — a new @BMESociety fellow & member of the board of directors. Not to mention co-chair of this week's #BMES2021. 🎉 https://t.co/JMhKAyjFyT #CoulterBME

[Bill Hanage @BillHanage.bsky.social @BillHanage]

Amen.

(For all that @NateSilver538’s pandemic takes have not always been tip top terrific, this is absolutely correct)

[Coulter BME | Emory & Georgia Tech @CoulterBME]

"You can be a scientist just like you are" - @DrPlattLab in conversation w/ @wkamaubell on #UnitedShades. They talk research funding disparities, imposter syndrome & more. ICYMI, re-airs 11p on 5/22 on @CNN and is available on demand.

[Nicholas A. Peppas @NPeppas]

Congratulations to Manu Platt @DrPlattLab (@GeorgiaTechBioE @BMES) for the 2021 @aimbe Award he received yesterday. Well done, great recognition of his exceptional and pioneering efforts to improve diversity.

[Platt Lab @DrPlattLab]

@Lola_UMich Thanks @Lola_UMich and to the others that came before me. Looking forward to meeting the many more coming behind us!

[Justin Pritchard @JustinPritcha19]

@peytonlab Congrats Manu! You rock!

[Peter Hudson @PeterPjh18]

25 years ago today, Thomas Hamilton walked into my children's school in Dunblane & shot 16 children. My colleague Mick North lost his daughter Sophie & started the Snowdrop Campaign to change the law on handguns. Death from gunshot in the UK has now fallen by 75%.⁠

[Clinical Cancer Research @CCR_AACR]

Results by Jones et al show that #doxorubicin can be administered at high cumulative doses with a low rate of cardiotoxicities in patients with soft tissue sarcomas in the context of dexrazoxane co-administration.
@RobinL_Jones bvantine1 #AACRrsm21
https://t.co/v0knek3CO4

[David M. McCandlish @TheDMMcC]

This is a great position for someone interested in epistasis or the structure of the genotype-phenotype map!

But I'm also very open to candidates with a physics, ML, oe math background looking to get into biology.

Informal inquiries welcome, please e-mail or DM!

[Platt Lab @DrPlattLab]

Thanks for this honor @AAASmeetings ! And the video is amazing, very touching with so many of my former students and current pridemakers! Love watching my #plattlabsquad change the world!

https://t.co/FEo5KNzLaa

@CoulterBME @ibbgatech @BlkInEngineerng @GT_BioE @GT_Esteemed

[Christian Pallasch @CPallasch]

So nice to see our paper in print at @BloodJournal
https://t.co/w75QpXShDJ

[David M. McCandlish @TheDMMcC]

@EES_update @Mark_P_Zwart @JustinPritcha19 @JeffTownsend @joshualevipayne @PeterALind @natarajan02 @ArlinStoltzfus