Kamal P Singh

tweeting in personal capacity

[Freemason @STARFORCEHH]

🧬🔬 In a groundbreaking study, researchers in Japan have shown it’s possible to use CRISPR to actually cut out the extra chromosome that causes Down syndrome, potentially reversing many of its cellular effects. Down syndrome happens when someone has three copies of chromosome 21 instead of the usual two. This extra genetic baggage disrupts how genes are read and proteins are made, leading to developmental differences, learning challenges, and various health concerns. Until now, treatments couldn’t touch this root cause—they could only help manage symptoms.

The team designed CRISPR guides that zero in on the surplus chromosome 21 and slice it out. This precise targeting, known as allele-specific editing, allowed the enzyme Cas9 to cut only where it was needed. When they removed the extra chromosome in lab-grown cells, gene activity returned to more normal levels. The treated cells also started growing faster, had healthier mitochondria, and produced fewer harmful molecules linked to aging.

What’s especially exciting is that the researchers tested this on both stem cells and mature skin cells from people with Down syndrome. Even in these fully developed cells, removing the extra chromosome worked in many cases. They found that genes tied to brain development became more active, hinting at how this might help neurons if the method ever reaches the brain.

It’s still early days—this won’t be in clinics soon. Scientists are refining the method to avoid accidental cuts on healthy DNA and to keep the edits stable. But this study proves CRISPR isn’t just for tweaking tiny gene errors; it might one day help clear whole chromosomes, offering hope for treating genetic conditions right at their source.

Research Paper 📄
DOI: 10.1093/pnasnexus/pgaf022

What are your thoughts on using gene editing for complex chromosomal conditions? What ethical considerations come to mind?

Disclaimer: This content is for informational and educational purposes only.

[Bharat Biotech @BharatBiotech]

#nucelion

[Dr Maya Valecha @VMaya11156]

Viral-vector means Covishield given in India, writing for those not aware.

[Awaken India Movement @awakenindiamvmt]

GM Maize-fed monkeys *showed indications of anaemia, kidney and thyroid disorders, and an altered gut microbiome*.

https://t.co/yVKhfp4ZqL

[Kamal P Singh @KBiotechexpress]

@ResearchSchola6 @realDonaldTrump @narendramodi ,,😉😉😉👏

[Rand Paul @RandPaul]

Deleting emails won’t erase the truth or the consequences. Fauci directed NIH staff to destroy records and circumvent oversight, an obstruction of accountability, not science. It’s time he faces Congress and answers for the damage done.

https://t.co/6KWoqr5IHc

[Dr.V.Mohan @drmohanv]

Congratulations to the top ten Indians in the field of Clinical Medicine/Endocrinology & Metabolism for the year 2025. 👏🏻👏🏻💐

[Jackson Hinkle 🇺🇸 @jacksonhinkle]

Do you agree?

Yes or no.

[Research Scholars of India(RSI) @ResearchSchola6]

Heartiest congratulations to Dr. Prashant Mathur, Director @ICMR_NCDIR, on receiving the Clarivate–Web of Science India Research Excellence Citation Award 2025. Recognised as the top scientist in Medical & Health Sciences (2019–24) @Ashutosh61 @adsahasrabudhe
@icarindia @ResearchSchola6 @CSIR_IND @GVRayasam @IndiaDST @CSIR_HRDG

[Research Scholars of India(RSI) @ResearchSchola6]

Centre of Bhrast Mental Research Lucknow (CBMR) Dibector Anok Bawan, Faculty Dr. Binesh asking bribe for PhD. Supported By Admin Officer Anar Dikshit.
Police Complaint has been Registered under Anti Corruption.

@nikhilgupta1532 @ResearchSchola6 @reachnidhi @myogiadityanath @Vigilante2801 @realDonaldTrump

[Kamal P Singh @KBiotechexpress]

@vivekagnihotri Did they invite u??

[Awaken India Movement @awakenindiamvmt]

2.5 month old baby died 18 hours after vaccination

Date: August 7th 2025
Place: Bargarh, Odisha

Per immunization schedule, Pentavalent, oral polio, rotavirus vaccines are administered at this age

https://t.co/Db34l2QfOt
https://t.co/ln4rP56c0l
https://t.co/DklAPcljAt
https://t.co/dVERKHpFrV
+++++++++++++++++++
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#StopVaccinating
#MissionIndradhanush
#IndiasForgottenBabies

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@Vaccinate4Life

[Kamal P Singh @KBiotechexpress]

@bainjal Piche Wale bhi has rahe hain,,

[Kamal P Singh @KBiotechexpress]

@Podcast_Radhika Saanch ko aanch nahi, she definitely is

[Indian National Science Academy (INSA) @insa_academy]

Fellows Elected
(Effective from January 1, 2026)
Sectional Committee-Wise

[Kamal P Singh @KBiotechexpress]

Contents in Current Issue of Biotech Express magazine highlighting @RFKJr_Official, father of @adarpoonawalla, @Strands @rajeevvarshney and many others.

[Kamal P Singh @KBiotechexpress]

As editor of Biotech Express, I'm excited to introduce our latest issue, boldly exploring the complex and controversial vaccine industry. Our in-depth coverage will continue over the coming months.
@RFKJr_Official @ChildrensHD @jeffreytucker

[Children’s Health Defense @ChildrensHD]

An 11-week-old baby girl got 20 vaccines in one visit. 6 hours later, she was dead.

For 12 years, DOJ & HHS fought to deny her parents justice.

A court has finally ruled: the vaccines killed her.

This ruling could set a precedent for thousands of families denied justice.

More than ten years of litigation to acknowledge what is clear and undeniable is an injustice to every grieving family.

Watch the full episode of ‘This Week with Mary & Polly’ on #CHDTV👇
https://t.co/McvYTXUeEX

[Barb Loe, NVIC @NVICLoeDown]

RFK Jr. Names New Members to CDC Vaccine Advisory Panel

The new members include a pediatric cardiologist and an OB-GYN.

#CDC #ACIP
https://t.co/MqBZsfH1Po