Kamil Nosol

Dr. sc. at @ETH Zürich. Crazy about #science: membrane proteins, cryoEM, phage display. There is always time for a psychological movie.

[Nature Communications @NatureComms]

lResearchers from @lab_locher and their coauthors show how hepatitis drug bulevirtide interacts with the receptor for HBV/HDV cell entry. #ntcp #hbv #bulevirtide #slctransporters #membranetransporters

https://t.co/MYBrv3BbfJ

[Membrane Protein PDB @MemProtPDB]

Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP | Nat Commun

https://t.co/YmMsoJwpx0

[Locher Lab @lab_locher]

We have exciting news on NTCP! In our very recent study - now out in @NatureComms - we found out how NTCP interacts with the antiviral drug bulevirtide.
Congratulations to @Hongtao_Liu2019 and the rest of the team #SLC #CryoEM
Find out more here: https://t.co/ToZPeS30KQ

[bioRxiv @biorxivpreprint]

Structure of hepatitis B/D antiviral drug Bulevirtide bound to its receptor protein NTCP https://t.co/B5bYUcNJB0 #bioRxiv

[Locher Lab @lab_locher]

We are excited to share our latest publication on the human liver drug importers OATP1B1 and OATP1B3 in functionally distinct states, now available in @NatureComms
Read more about the novel bicarbonate binding site here: https://t.co/0sZRxOHQnj

#SLCtransporters #cryoEM

[Locher Lab @lab_locher]

ABCG2 meets nanobodies! Check out our new publication on ABCG2 inhibition: https://t.co/LHli3EKnzK
#ABCtransporters #ABCG2 #nanobodies #cryoEM

[Locher Lab @lab_locher]

New Year, new lab picture!😀

[J. Andrew Alexander @J_A_Alexander]

I was dismayed (to say the least) to find @DeepMind AlphaFold predictions come up when I searched for a PDB file at @buildmodels. AF is a useful tool and its great that @uniprot hosts calculated AF predictions, but I see no reason for them to also be hosted by @buildmodels.

[Hideaki E. Kato @emeKato]

new release6

7ZYI: Structure of the human sodium/bile acid cotransporter (NTCP) in complex with Fab and nanobody

"Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver."

Locher lab. Cell. Res.

[Jensen Lab @theJensenLab]

Check out our new @biorxivpreprint with @mikhailshapiro on the structure of bacterial gas vesicles: https://t.co/Q7DLaP2JVX
Congrats to @przemyslawdutka and all authors!

[Locher Lab @lab_locher]

We are proud to present our newest paper on the structure and mechanism of the human bile salt transporter NTCP. A fantastic team effort!

https://t.co/ZcTy9fm5qo

Congratulations #TeamNTCP

[Filippo Mancia @pippomancia]

WaaL highlights by first author @Khuram_U_Ashraf!

[Andrea Pasquadibisceglie @andpdb.bsky.social @AndPdb]

This has been a great week, in a wonderful place, with fantastic people. Thank you @accardilab for organising this. I hope to see you all again soon! @GordonConf #LigandRecognitionAndMolecularGating

[Transporters and Solute carriers @solutecarriers]

Discovery and Characterization of Potent Dual P-Glycoprotein and CYP3A4 Inhibitors: Design, Synthesis, Cryo-EM Analysis, and Biological Evaluations https://t.co/laNINe1oB8

[Filippo Mancia @pippomancia]

We're looking for a post-doc! If you're interested in membrane protein biochemistry & structural biology, see: https://t.co/UEBBm5gNZu #ManciaLab @ColumbiaPS #cryoEM - Please RT!

[Locher Lab @lab_locher]

Congratulations to @KNosol who successfully defended his PhD thesis. You did a fantastic job, Kamil! #ABCTransporters

[Locher Lab @lab_locher]

We are happy to share our latest article, now available online @PNASNews. Check out our #cryoEM structures of the #membranetransporter ABCB4 and more on how the transporter translocates phosphatidylcholine here:
https://t.co/M2E1g4HTVY

Congrats to @KNosol and all the authors!

[cryoEM Papers @cryoEM_Papers]

Structural basis of drug recognition by the multidrug transporter ABCG2 https://t.co/2MJ1pChdMq

[Jensen Lab @theJensenLab]

Check out our new @biorxivpreprint with @mikhailshapiro group on using EM to measure gas vesicles: https://t.co/xAedLwCrSX

[Kamil Nosol @KNosol]

@spant_18 @tcbguiuc @emadtaj @BeckmanInst https://t.co/488eFECplx