Yasar Arfat T Kasu

[Yasar Arfat T Kasu @KasuYasar]

@SignerLab @ISEHSociety Congratulations Rob🥳🥳!!! Absolutely deserving⭐️🤩

[nature @Nature]

Ribosomes take a break from their usual role https://t.co/hNxYKAxWhM

[Robert Signer @SignerLab]

Can anti-aging antibodies revive the immune system? In @NatureNV we previewed the latest breakthrough from Irv Weissman's team in @Nature that used immunotherapy to deplete aging stem cells. @KasuYasar https://t.co/2S9SO08g2y

[Eric Topol @EricTopol]

🆕 @Nature
Rejuvenating the aged immune system with antibody depletion of blood myeloid stem cells @justsaysinmice
https://t.co/PdU3bbUgZe
https://t.co/mzAWXFxheH
@HOSTvsVirus @SignerLab @KasuYasar
Big implications

[Yasar Arfat T Kasu @KasuYasar]

@jasmeetkvirdi @Prasad24330246 This is gr8!!! Congratulations🤩🥳

[Yasar Arfat T Kasu @KasuYasar]

@DrAveritt @djc1901 Congrarulations Daisy🤩🤩🤩

[David Steensma, MD @DavidSteensma]

Did you ever wonder why our marrow is located inside of our *bones*, #MedTwitter? There’s no a priori anatomical reason it should be sited there. Blood cells could form in our spleens & livers, as they do during our fetal lives; or elsewhere, as in some animals. Let’s discuss! /1

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.

[Yasar Arfat T Kasu @KasuYasar]

@ParamitaBasu21 @PittAnes @PCPRpgh Awesome newzz!!!!🤩🤩🤩 Congratulations😀

[Frydman Lab @FrydmanLab]

Out now! Unveiling the mystery of TRiC/CCT chaperonin assembly! 🥳Our paper uncovers how its unique double-ring architecture forms through a step-by-step hierarchy. Many congrats to the first authors @mirandacollier @KarenBetaMor! 😍
Check out more here:
https://t.co/xx3RiFmWdA

[ISRO @isro]

Chandrayaan-3 Mission:
'India🇮🇳,
I reached my destination
and you too!'
: Chandrayaan-3

Chandrayaan-3 has successfully
soft-landed on the moon 🌖!.

Congratulations, India🇮🇳!

#Chandrayaan_3
#Ch3

[Veera Rajagopal  @doctorveera]

A mind-blowing paper has come out today in @Nature

In 2016, JC Venter Institute scientists trimmed a bacterial genome to its barest minimum required for life to synthesize what they called a "minimal genome" (https://t.co/Rk8oZJ0bUj).

Today, a group of scientists from Indiana University reports how that minimal genome evolved over 2000 generations in comparison to the non-minimal genome.

The authors found that even when you reduce a bacterial genome to its absolute minimum where every nucleotide matters, the genome undergoes mutational events generation after generation as much as the non-minimal genome. One simply cannot stop the evolution.

Just over 300 days of evolution (equivalent to 40,000 years in humans) the minimal cell has gained everything it lacked in fitness on day one in comparison to the non-minimal cell.

When comparing the evolved traits between the minimal and non-minimal cells, the scientists found something striking. The evolutionary process increased the cell size of non-minimal cells but not that of the minimal cell. But that is not the striking part.

The scientists were able to identify the key mutation that resulted in cell size evolution. And it turned out that the mutation that helped the non-minimal cells to grow bigger is the same that helped the minimal cells to stay smaller. Growing bigger had a survival advantage for non-minimal cells and not growing bigger had a survival advantage for minimal cells. So, the mutation had a context-dependent effect. This just demonstrates that the evolutionary effects on traits have no absolute direction. All that matter is what is beneficial for the organism's survival.

The conclusion of the paper is metaphorically a quote from the Jurassic Park movie:

“Listen, if there’s one thing the history of evolution has taught us is that life will not be contained. Life breaks free. It expands to new territories, and it crashes through barriers painfully, maybe even dangerously, but . . . life finds a way". (https://t.co/UlxRlb86CT)

https://t.co/zA9OAqSoAu

[Cenik Lab @CenikLab]

Ribo-ITP enables ribosome occupancy measurements from single cells. Our first application revealed insights into allele-specific ribosome engagement in early development (https://t.co/BA27Bc5ZGh). #RiboITP #singlecell

[Rodrigo Reis @Rodrigo_S_Reis]

Mechanisms of readthrough mitigation reveal principles of GCN1-mediated translational quality control
Cell
https://t.co/mPx1IkknXd

[Kira Gritsman @Gritsman_lab]

Happy to be part of this fun collaboration with Nick Baker- in this study led by @FolgadoVirginia and Kristina Ames we show that the ribosomal protein RpS12 is required for skeletal development and hematopoiesis in mice https://t.co/DjUGjc0qD9

[Yasar Arfat T Kasu @KasuYasar]

@DrAveritt @txwomans 🤩🤩🤩🤩 congratulations @RituparnaSinha9 😍, Ann Davenport and Mengie Cao🥳

[Robert Signer @SignerLab]

For 50 years we've known that recycling helps keep our planet healthy. Now we know it's also essential to boost stem cell fitness & longevity.

[Yasar Arfat T Kasu @KasuYasar]

@DrGTWU @Farhanlakdawal4 @TWU_CAS 🎉🎉🎉 great addition to @abbvie!!

[Yasar Arfat T Kasu @KasuYasar]

@TWUGradDean @GradSchoolTwu @txwomans 🎉🎉🎉🎉 @Farhanlakdawal4 and @AkshayaArva !!!

[Ran Blekhman @blekhman]

Breakdown of PhD student cost on a grant:

tuition $45K
stipend $35K
fringe $10K
indirects $60K
--
total paid by NIH to university: $150K
total paid by university to student: $35K

(this is just a toy example to illustrate a point, not real numbers but same ballpark)