KinnunenLab

Research group of Tuure Kinnunen at @UniEastFinland. All things immunology, with a particular interest in T cells and autoimmunity

[KinnunenLab @KinnunenLab]

New science out from our group, this time looking at the specificities of autoantibodies in patients with juvenile idiopathic arthritis #JIA.

[ACR_Journals @ACR_Journals]

Plasma samples from untreated patients with active JIA were analyzed for ANA specificities. Results showed chromatin was the main target of autoantibody reactivity in JIA, and 20% of JIA patients had reactivity to dsDNA-nucleosome complexes

A&R
https://t.co/wV176y9Bom

[Scale Biosciences @scalebio]

🌍 QuantumScale training sessions happening across continents!
Same commitment everywhere: Your breakthrough = our success
Real support. Real results. Real partnership. https://t.co/HOdLtPpK9J
#GlobalScience #SingleCellRNA #ScaleBio

[KinnunenLab @KinnunenLab]

Interesting observation: turns out mouse PD-1 is less inhibitory than human PD-1, so many observations in mouse cancer immunotherapy models may not hold true in humans. Another fine example why we need more human studies and/or more humanized rodent models.

[Enfu Hui @hui_enfu]

Thrilled to share our @SciImmunology paper! Rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. Kudos to @MasubuchiTakeya for leading this work, and @jackbuimdphd @ZhengtingZou @CWu2009 et al. for collaboration.https://t.co/N1NbfwibLA See also excellent media report by @mario_maguilera https://t.co/TiHuiMuesI

[Eric Topol @EricTopol]

An exciting advance in Type 1 diabetes
First person to receive her own stem cells, reprogrammed with transcription factors, to reverse it!
@CellCellPress
https://t.co/NzhTO6tZrg
@Nature
https://t.co/zbNNtLCrot

[KinnunenLab @KinnunenLab]

Huge congratulations @SchAnnMari for brilliantly defending your thesis today! And many thanks @lettipitko for acting as the opponent and leading the inspiring discussions.

[University of Eastern Finland @UniEastFinland]

Doctoral defence of Anna-Mari Schroderus, MSc, 13 Dec 2024: Alterations in T-cell landscape observed at different stages of type 1 diabetes progression. @ClinmedUef @UEFMetabolicRC https://t.co/X2LH8hEsvg

[University of Eastern Finland @UniEastFinland]

T-solupopulaatioissa tapahtuu tyypin 1 diabeteksen kehittymisen eri vaiheissa muutoksia, joista voisi ehkä tulla biomarkkereita hoitoon, havaitsi FM Anna-Mari Schroderus väitöstutkimuksessaan. Väitös Kuopiossa 13.12.2024. @ClinmedUef @UEFMetabolicRC https://t.co/61OrGfchxJ

[KinnunenLab @KinnunenLab]

Interesting early success by CAR-T therapies to treat (highly selected!) patients with severe autoimmune diseases, like lupus.

[Eric Topol @EricTopol]

How engineered T cells are changing the face of autoimmune diseases via B cell depletion
https://t.co/yREY9OSeyY @ScienceMagazine @NewsfromScience @jcouzin open-access

[KinnunenLab @KinnunenLab]

@lettipitko No nyt on kova suoritus, hattua päästä ja suuret onnittelut Eliisa! 👏

[Petter Brodin @BrodinPetter]

New paper out @Nature - why are males more vulnerable to severe infections (ex acute #COVID), while females suffer more from autoimmunity (SLE, MS etc and also #LongCovid)? sex chromosomes or hormones?

Here we studied adaptation of human immune systems to gender-affirming testosterone treatment in trans-men assigned female sex at birth: https://t.co/HzCQI6GUwn

[KinnunenLab @KinnunenLab]

@ImmunoSketch Yes, thanks for highlighting our research of course! Science communication is very important. My point is that hopefully people will still read the actual abstracts/papers in the future and not just the AI-generated synopsis…

[KinnunenLab @KinnunenLab]

Ok, so this is the future I guess. Someone made an AI-generated 30 sec highlight of our research paper. Looks and sounds very convincing on the surface, but on a closer look the pictures and texts in the animation are complete gibberish…

[ImmunoSketch @ImmunoSketch]

An early CMV infection can reprogram your immune system's 'software' for years, like a computer update that sticks around.

@KinnunenLab @ClinmedUef @helsinkiuni @UniTurku @UniOulu

https://t.co/xPzsbuRNur

[KinnunenLab @KinnunenLab]

5/ Thanks again to all the collaborators at @ClinmedUef @helsinkiuni @UniTurku @UniOulu, and of course the funding sources @SuomenAkatemia @SigridJuselius

[KinnunenLab @KinnunenLab]

1/ Check out our recent translational research on the effect of early life CMV infection on T cell memory in children!
https://t.co/2DyInckWhk

[KinnunenLab @KinnunenLab]

4/ The mechanism is completely speculative, but recently there have been some evidence for a protective effect on autoimmunity for certain subsets of highly differentiated CD8+ T cell subsets, such as the CD8+KLRG1+TIGIT cells, we recently studied in #T1D: https://t.co/7Rd404S9kU

[University of Eastern Finland @UniEastFinland]

Verenkierron CD8-positiivisissa T-soluissa tapahtuu erityyppisiä muutoksia tyypin 1 diabeteksen kehittymisen eri vaiheissa, osoittaa Itä-Suomen yliopiston tutkimus. Tieto voi auttaa tyypin 1 diabeteksen kehittymisen ennustamisessa. @KinnunenLab @SchAnnMari https://t.co/4s7e1uIV26

[University of Eastern Finland @UniEastFinland]

Two distinct signatures were detected in a subset of circulating, highly differentiated CD8-positive T cells in children at different stages of type 1 diabetes development. The study was led by prof. Tuure Kinnunen at the #UEF. @KinnunenLab @SchAnnMari
https://t.co/cGiiWA4mHA