Institute of Molecular Immunology

#HBV #Tcells #tissueimmunity #antiviral #anticancer #immuneregulation #immunotherapy #preclinicalmodels #clinicaltranslation #imagingmassspec

[WüSI - Systems Immunology Würzburg @Wue_SI]

A second priming phase promotes high-affinity CD8 T cells by coordinating CD4 help and the relay of IL-2 in subfollicular LN niches. Congrats to @Wue_SI’s Kasia, Deeksha, @Kamu_Lab @GeorgGasteiger . https://t.co/blqqihSvbJ

[Institute of Molecular Immunology @KnolleLab]

Job alert in our Institute of Molecular Immunology!

Two PhD positions in the field of immune regulation in autoimmune liver diseases. Both positions are embedded in the newly funded CRC1700 together with Hamburg.

Please check our official job announcement for more information

[Institute of Molecular Immunology @KnolleLab]

We are proud to host the GASL Annual Meeting 2025 from 14-15 February in Munich. The GASL program with fanatastic talks and poster is out now! Here you can find it👇

[Institute of Molecular Immunology @KnolleLab]

We are proud to announce that the SFB 1700 Initiative "Immunregulation in der Leber: von Homöostase zur Krankheit" in which we will be part of will be funded for the next four years!🥳 Exciting opportunitiy to unravel immune-mediated mechanisms of autoimmune liver diseases!

[DFG public | @[email protected] @dfg_public]

Die #DFG richtet zur weiteren Stärkung der #Spitzenforschung an den Hochschulen 7 neue #Sonderforschungsbereiche (SFB) ein. Die Themen reichen von Materialübergängen oder der Wiedervernässung von Mooren bis zur Immunregulation in der Leber. Einzelheiten:
➡️https://t.co/kXJWN77KRp

[Institute of Molecular Immunology @KnolleLab]

@JBoettcherLab @dgfi_org Huge congrats to Jan and the whole @JBoettcherLab for this fantastic award! Well deserved! 🥳

[Institute of Molecular Immunology @KnolleLab]

@pallett_lab Thank you, Laura! 🥰

[Institute of Molecular Immunology @KnolleLab]

@luglilab @Nature Thank you, Enrico!😊

[Institute of Molecular Immunology @KnolleLab]

We are excited that our study on the liver immune rheostat regulating CD8 T cell immunity in chronic HBV infection is published!🥳 @nature (https://t.co/5iLVpda4lM)

[Institute of Molecular Immunology @KnolleLab]

Huge thanks to all of our collaborationpartners for their contributions and continuos help! @ProtzerLab @JBoettcherLab @maini_lab @LauerLab @LabOxenius

[Institute of Molecular Immunology @KnolleLab]

🔎HBV-specific CD8 T cells are in close & prolonged contact with liver sinusoidal endothelial cells when recognizing their antigen on hepatocytes. We termed this close & prolonged contact an immune rheostat, that increases cAMP-PKA signalling and hampers T cell effector functions

[Institute of Molecular Immunology @KnolleLab]

Huge thanks to all of our collaborationpartners for their contributions and continuos help! @ProtzerLab @JBoettcherLab @maini_lab @LauerLab @LabOxenius

[Cell @CellCellPress]

Now online! Therapeutic potential of co-signaling receptor modulation in hepatitis B https://t.co/UmdmJBGSUi

[Institute of Molecular Immunology @KnolleLab]

@iannaconelab @CellCellPress Wow, amazing study! Huge congratulations 🥳 another major step forward to sucessfully treat HBV patients!

[Waggoner Lab @LabWaggoner]

A single-cell in vivo CRISPR screen highlights genes driving T cell tissue adaptation and plasticity in autoimmunity @SciImmunology https://t.co/GPPfxDkO8t

[Waggoner Lab @LabWaggoner]

NK cells undergo tissue redistribution during fasting, where the spleen and bone marrow microenvironments metabolically reprogram and prime NK cells to increase anti-tumor function @ScientistBecs @SunLab_Official @ImmunityCP https://t.co/ncvFp9DFsk

[Institute of Molecular Immunology @KnolleLab]

Shape of naive T cells shapes the immune response. Pretty cool findings!
://www.science.org/doi/10.1126/science.adh8967

[Mirco J. Friedrich @mircoscopy]

Excited to share our latest publication in @SciImmunology! We've uncovered an NK cell-mediated immune checkpoint (B7H6 : NKp30) that limits CAR T cell persistence, revealing new insights into immune regulation. #Immunology @broadinstitute @DKFZ
https://t.co/kACTBOzomC