Krishnamoorthi Srinivasan

Structural biologist | Postdoctoral researcher at @thisisUIC | Co-founder @biospeakweb | Loves discussing science, psychology, philosophy and football

[Oded Rechavi @OdedRechavi]

Trying to keep up with the literature

[Priya Baid @priyabd1]

Check out our new publication revealing how mycobacterial EF-G2 stands apart than its other counterparts!!

Cryo‐EM structural analyses reveal a unique role for elongation factor G2 (EF‐G2) in Mycobacteria - Baid - The FEBS Journal - Wiley Online Library https://t.co/jt4XF0Yhs4

[Krishnamoorthi Srinivasan @KrishS_023]

@AlbertW_Lab @IGBMC @Inserm @CNRS @unistra @ERC_Research @IMC_Bio @instructhub Beautiful work! Such an elegant system. This answers one of the most fundamental questions on translation initiation. Congratulations to all the authors!

[Carl Anka is on leave @Ankaman616]

I hope the author of Today's Wordle puzzle has a terrible day.

[Krishnamoorthi Srinivasan @KrishS_023]

@debashmitasark5 @CMLSjournal @DuttShilpee @CRI_ACTREC @amartya_acad @SHAINAMANDI Congrats!! 😄

[Krishnamoorthi Srinivasan @KrishS_023]

Massive complex, in magnanimous details! Congrats to all the authors involved!

[conti_lab @LabConti]

Excited to share our latest research on co-translational mRNA decay by the exosome in human cells! We uncover how the exosome-SKI complex is recruited to ribosomes and propose a novel role for SKI in recognizing collided disomes. @MPI_Biochem
👇👇👇

[Krishnamoorthi Srinivasan @KrishS_023]

What a cool discovery!

[ShorterLab @ShorterLab]

Ribosomes hibernate on mitochondria during cellular stress: https://t.co/uVo1MSYpI7

[Ribosome Papers @ribosome_papers]

bioRxiv: Cytoplasmic ribosomes hitchhike on mitochondria to dendrites https://t.co/KbGUrvauAd

[C-CAMP @CCAMP_India]

🚨New #Publication Alert!

The National Electron Cryo Microscopy facility at the Bangalore Life Sciences Cluster @BLiSC_India has supported a new study by researchers from @csir_iicb and @AcSIR_India!

The team decoded the exact mechanism by which mycobacteria resist macrolide #antibiotics.

They found how the protein HflX plays an important role in this resistance, and targeting this mechanism could make #mycobacteria more vulnerable to existing antibiotics!

The team studied how HflX & a nucleotide (A2286) are affected by the antibiotic erythromycin in Mycobacterium smegmatis. They found that the conformation of A2286 is altered by erythromycin binding. HflX senses the presence of erythromycin via this conformation and binds more strongly to ribosomes, which likely acts as a first line of defence against the antibiotic.

These findings help explain how HflX detects macrolides antibiotics and contributes to the bacteria's resistance.

@Taslimarif @DBTIndia @NCBS_Bangalore @DBT_inStem @KrishS_023

[Krishnamoorthi Srinivasan @KrishS_023]

@sushant16m8 @Structure_CP @csir_iicb Unlike the ones incharge of my fellowship, I have done my due diligence, that too in a timely manner😂

[Krishnamoorthi Srinivasan @KrishS_023]

Happy to share a big chunk of my PhD work, published now at @Structure_CP!
Big thanks to my guide Dr. Jayati Sengupta, @csir_iicb and my co-author Aneek Banerjee!

[Structure @Structure_CP]

Online now! Cryo-EM structures reveal the molecular mechanism of HflX-mediated erythromycin resistance in mycobacteria https://t.co/KFjswt4PBt

[Krishnamoorthi Srinivasan @KrishS_023]

@abandopa No we can't. The whole process is stalled now. Vendors say there is no clarity on the exemption, and when they are ordering the chemicals, the sigma site is still showing the enhanced 150% import duty.

[Krishnamoorthi Srinivasan @KrishS_023]

What an experiment🤣🤣

[Juan A. Rodríguez @jrotwitguez]

Then we repeated the experiment, but we dehydrated the tissue first. The architecture was fine. We left it at room temperature for a year. Still fine. Ran over it with a car, had a former Astros starting pitcher throw a fastball at it, fired a shotgun at it. Still fine. (15/18)

[Krishnamoorthi Srinivasan @KrishS_023]

@GbNaib 🤣

[Krishnamoorthi Srinivasan @KrishS_023]

@amuk3702 Many congratulations to the whole team! The world needs more such collaborative efforts!

[Israel Fernandez @IsraelF96135088]

CryoEM labs doing ribosomes!

[Krishnamoorthi Srinivasan @KrishS_023]

@RupamPa96165633 @iiserkol @CopperBioGroup Congrats Dr. Rupam Paul! 😄

[Chennai Super Kings @ChennaiIPL]

“A gift for the fans.” - THA7A FOREVER! 🦁💛

#Dencoming #WhistlePodu

[Sergey Melnikov @SergeyVMelniko1]

Bacteria have an astonishing ability to put their life on pause in the face of stress and starvation by entering a state of dormancy. Here, we discover one aspect of this remarkable self-preservation strategy: https://t.co/iQJ2biOHkx

[Krishnamoorthi Srinivasan @KrishS_023]

@AritraBej @MOZUMDERSukanya Congratulations!