Maria Domercq

We investigate oligodendrocytes/myelin and microglia in myelination/remyelination at @AchucarroGlia and @upvehu

[Maria Domercq @LabDomercq]

New paper is out in Brain, Behavior, and Immunity!! 🥳

"P2X4 Drives Sex-Specific neuroprotection in autoimmune neuroinflammation"

https://t.co/PuTGIdakL0

We found that the purinergic receptor P2X4 protects against neuroinflammation, but only in females. Why? 🧵👇

[Diego Clemente's lab @DrDiegoClemente]

📢🧠 New preprint from our group available on @medrxivpreprint.

In this longitudinal study in early untreated RRMS patients, circulating M-MDSCs were associated with immune regulatory dynamics and better relapse recovery.

Congratulations to all authors!

https://t.co/UsfNtbf5gP

[Mariela | Neurodocente 🧠 @neurodocente]

Following Bolaños & Magistretti’s October 2025 review on the neuron–astrocyte metabolic unit, the November 2025 Nature Metabolism review by Asimakidou, Pluchino, Silva and colleagues brings microglia–neuron interactions into the discussion.

They are not examining the same cellular mechanism, what connects them is the broader move to place neuronal function within the cellular interactions that shape brain metabolism and brain function.

The November review adds the neuroimmune dimension, linking microglial metabolism to cognition, ageing, and disease.

[Maite Solas @maitesolaszu]

Can't wait for this fantastic Symposium!

[Ali Max Erturk @erturklab]

Does brain aging always mean vessel loss?
🧠We found a surprising hypervascularization, driving cognitive decline & blood-brain barrier damage in aging. 👇🧵https://t.co/i3pWeowcLQ Led by @MihailMuc

[Sauralab @sauralab]

Take a look at our new article! We demonstrate that the Alzheimer´s disease gene Presenilin regulates tau pathology via the autophagy & proteasome pathways. Funded by @CienciaGob @AgEInves @CIBER_ISCIII #CIBERNED @_BrightFocus @INC_UAB https://t.co/jneW86C1n3

[Maria Domercq @LabDomercq]

Today I submitted my review of a manuscript for a journal, which I will not name, and then received the comments sent to authors. There were 7 reviewers!!! Have we lost all sense?

[Science girl @sciencegirl]

Turkish photographer Uğur Gallenkuş portrays two different worlds within a single image

[Maria Domercq @LabDomercq]

@FdeCastroS Gracias Fernando!!

[Maria Domercq @LabDomercq]

New paper is out in Brain, Behavior, and Immunity!! 🥳

"P2X4 Drives Sex-Specific neuroprotection in autoimmune neuroinflammation"

https://t.co/PuTGIdakL0

We found that the purinergic receptor P2X4 protects against neuroinflammation, but only in females. Why? 🧵👇

[Maria Domercq @LabDomercq]

@BaleriolaLab Gracias Jimena!!!

[Maria Domercq @LabDomercq]

Congratulations to @salgado_mata for her excellent work and to all collaborators, particularly @BoueGrabot
@upvehu @AchucarroGlia #ARSEP foundation @bioef_

[Maria Domercq @LabDomercq]

3) This reveals that sex hormones shape neuroinflammatory outcomes through direct modulation of microglial P2X4 function, opening the door to precision, sex-aware therapeutic strategies for MS.

[Thora Karadottir Lab @ThoraKaradottir]

What happens to the brain after focal myelin loss? Our new paper, published today in @Nature tries to answer this question: https://t.co/dCM1kcPd5N
Details in the 🧵 (1/8)

[Maria Domercq @LabDomercq]

@jposeutrilla @AchucarroGlia No, lo siento.

[Maria Domercq @LabDomercq]

Minisimposium on #ASD: genetics, molecular mechanisms, circuits and behaviour. Organized by @UPV/EHU and @AchucarroGlia. Join us!!! Speakers and details below.

[Maria Domercq @LabDomercq]

Achucarro Glia School is backed!!! Please check the program. Excellent speakers. Great opportunity to learn on Glia!!!
https://t.co/Tel5UKau6M

[GlioMatrixLab @GlioMatrixLab]

📢Registration for the Achucarro International Glia School 2026 is now open!
https://t.co/Y5CkxWAcSu
📆Deadline for pre-applications: 31 March 2026.
📜All-inclusive tuition (450€) covers scientific sessions, coffee breaks, lunch, social dinner and accomodation (shared rooms)

[Simons Foundation @SimonsFdn]

A recent study found that mice with variants in autism-associated genes have difficulty flexibly updating their expectations, providing new insights into the neurobiology of autism: https://t.co/olxrmHtWsl #neuroscience #BrainAwarenessWeek #BrainWeek

[Maria Domercq @LabDomercq]

Excited to be back again at Sfari meeting in NY. Excellent meeting, finding colleagues, new ideas, excited findings. Thanks to @SimonsFdn for organising and support