Cheng Fly Lab

We are interested in how nutrient, and metabolism affects stem cells and tumours

[Peter Mac Cancer Centre @PeterMacCC]

🧠 New research shows the blood–brain barrier helps control #braintumour growth.

Led by Prof Louise Cheng in @LabFly , the study finds glial “gatekeeper” cells and a protein called Path influence how #cancer respond to low nutrients.

Read more: https://t.co/Rp3KPx0N4h

[Ben Hogan @BenjaminHogan13]

Come and join us! We are looking for a bioinformatician to join the lab. Work with single cell, multiome and spatial data from model systems and human samples! Our focus is lymphatics and blood brain barrier in development, regeneration and cancer.
https://t.co/Zw6rcVxK9h

[Cheng Fly Lab @LabFly]

Congratulations @khanh_ng97 on the ECR publication prize @AusFly2024 for https://t.co/WwuSd2H4FP

[Cheng Fly Lab @LabFly]

@Fumiaki1984 @HarveyHippoLab @SHCrossman Great having you in Melbourne, what a nice time we had with you and @Hina_kosakamoto

[Alex Gould Lab, now only @alexgouldlab.bsky.social @AlexGouldLab]

Our latest from @TheCrick …
Sebastian Sorge led on this amazing new chemically defined (holidic) diet for fast larval growth & development in Drosophila. It’s called HoldFast, soon to be available to the community, in powdered form, from @VDRC_flies.

https://t.co/Mhbp023SFE


[Cheng Fly Lab @LabFly]

It was a privilege to appear on @RRR to talk about our research and discuss what patients should know about cancer cachexia - a metabolic wasting disease affecting cancer patient outcomes. Grateful to our consumer Sudhir Sakhuja and my clinical collaborator @HyunKoMD.

[Peter Mac Cancer Centre @PeterMacCC]

"Cancer cachexia" affects 30% of cancer patients - 80% for advanced cancers - and yet few have heard of the term. Assoc Prof Louise Cheng (@LabFly), @HyunKoMD and cancer survivor Sudhir, have explained this muscle wasting condition to @3RRRFM.

Listen: https://t.co/LDeZH61Xi5

[Hongyan Wang @HongyanWang9]

Paper is out! Astrocytes control quiescent NSC reactivation via GPCR signaling–mediated F-actin remodeling | Sci Adv https://t.co/7i1AUONka7
Kudos to super talented lab members @LukeKunYangLin1 @mahekta @jiaen_lin @GaoYang43766353 and wonderful collaborators @Yusuke_Toyama & Tony

[Crete Fly Neuro @CreteFlyneuro]

We are excited to announce the next Workshop on Neural Circuits & Behavior of Drosophila that will be held at the Orthodox Academy of Crete (OAC), Kolymbari, from June 15-21, 2025. Please RT.

[fly-jedi.org @FlyJedi]

Missing our @FlyJedi meetings? The #JEDI are back for great #Drosophila science! Follow us for more news and dates! #thereturnofthejedi

[Kat @KatMitchell_Sci]

Very excited to share our #preprint in @biorxivpreprint in which we found that the transcription factors of JNK and Hippo pathways control epithelial integrity by regulating an overlapping transcriptome 🧵1/10

[Cheng Fly Lab @LabFly]

@PeterMacRes @PeterMacCC @UniMelb

[Cheng Fly Lab @LabFly]

Happy to share the latest work from the lab, led by our PhD student Khanh Nguyen @khanh_ng97
https://t.co/67DQ109dpc @eLife

[Cheng Fly Lab @LabFly]

As the Drosophila OL shares a similar mode of division with mammalian neurogenesis, understanding when and how these progenitors cease proliferation during development can have important implications for mammalian brain size determination and regulation of its overall function.

[Cheng Fly Lab @LabFly]

@jpvincentlab @AlexGouldLab @epiddin @OttolineLeyser Congratulations JP!

[Cheng Fly Lab @LabFly]

@BenjaminHogan13 @vascularbiology @PeterMacRes @UniMelbMDHS Congratulations Ben, loved your lab’s gift to you! Congratulations to the lab too.

[Patricia Jusuf @pr_jusuf]

@LabFly @VeenKellie @UniMelb Amazing work by @VeenKellie and great collaboration with @theo_brainc_lab and @AaronKrylov .

[Cheng Fly Lab @LabFly]

We thank the reviewers @ReviewCommons for expert reviews, fast turn-around and great suggestions.

[Cheng Fly Lab @LabFly]

Two papers out this week from the lab!

[Cheng Fly Lab @LabFly]

As muscle ECM proteins are mostly fat body-derived, the retention of ECM proteins in the fat body causes a reduction in muscle ECM, which results in muscle detachment during cancer cachexia.