Perrimon Lab

Dr. Norbert Perrimon's lab at Harvard Medical School researches functional genomics, cell circuitry, and tissue homeostasis in Drosophila melanogaster.

[Perrimon Lab @PerrimonLab]

ABC transporters support Drosophila intestinal stem and progenitor cells during cytotoxic challenge
Dayton, Russo, Kolbert, Williamson, Balciunaite, DSouza, Becker, Hosage, Issa, Lu, Viswanatha, Kondo, Perrimon, Markstein
doi: https://t.co/ELMJomziVi

[Perrimon Lab @PerrimonLab]

Spatial isotope tracing maps compartmentalized nutrient use across the adult fruit fly
Moon, Huang, Blum, New, Park, Chen, Nishida, Pister, Nahid, Hu, Tennessen, Fraenkel, Asara, Davidson, Perrimon
doi: https://t.co/JqDMs7wMAI

[Perrimon Lab @PerrimonLab]

FlyAnatoView: Visualization of Drosophila Single-cell RNA-seq Datasets on Anatomographs
Hu, Kalina, Veal, Ewen-Campen, Tarryn Porter, Julia Song, Luo, Huang, Goutte-Gattat, Brown, Papatheodorou, Perrimon
bioRxiv 2026.09.28.755010; doi: https://t.co/kCCrRlcvb9

[Perrimon Lab @PerrimonLab]

FlyAnatoView: Visualization of Drosophila Single-cell RNA-seq Datasets on Anatomographs
Yanhui Hu et al,
bioRxiv 2026.09.28.755010; doi: https://t.co/kCCrRlbXlB

[Perrimon Lab @PerrimonLab]

Lipids regulate export of lysosomal enzymes from the endoplasmic reticulum.
Xia B, Han M, Park I, Perrimon N. Proc Natl Acad Sci U S A. 2026 Sep 22;123(38):e2616684123. doi: 10.1073/pnas.2616684123. Epub 2026 Sep 17. PMID: 42752232

[Perrimon Lab @PerrimonLab]

The Drosophila Secretome
Yanhui Hu1, Nahid Ausrafuggaman, Jenna Kalina, Austin Veal, Mujeeb Qadiri, Ah-Ram Kim, Norbert Perrimon
doi: https://t.co/EMAF2kgy0V

[Perrimon Lab @PerrimonLab]

Yanagawa K, Perrimon N. Extracellular vesicles in Drosophila and mammals: Conserved mechanisms and emerging functional roles. EXO. 2026;1(3):202615. doi: 10.70401/EXO.2026.0014. PMID: 42598228

[Perrimon Lab @PerrimonLab]

Lee, et al. (2026). Antigen presentation by CD40+ MHC-II+ astrocytes promotes CNS autoimmunity. Nature. doi: 10.1038/s41586-026-10860-6. PMID: 42557325

[Perrimon Lab @PerrimonLab]

In-situ glial cell-surface proteomics identifies pro-longevity factors in Drosophila.
Marques et al. Elife. 2026 Aug 18;14:RP109422. doi: 10.7554/eLife.109422.

[Perrimon Lab @PerrimonLab]

A pro-apoptotic selection strategy enables CRISPR screening in mosquitoes and identifies Lachesin as a chikungunya virus entry factor
Anja C. M. de Bruin et al.
bioRxiv 2026.07.31.742019; doi: https://t.co/VK1122DFzH

[Perrimon Lab @PerrimonLab]

Lachesin is a mosquito receptor for multiple arthritogenic alphaviruses
Plung et al.
bioRxiv 2026.07.28.741058; doi: https://t.co/8mNr17enh5

[Perrimon Lab @PerrimonLab]

Hu, Y., Comjean, A., Gao, C., Veal, A., Yamamoto, S., Mohr, S.E. and Perrimon, N. (2026) DIOPT: the DRSC Integrative Ortholog Prediction Tool, 2026 update. Genetics. doi: 10.1093/genetics/iyag194. PMID: 42504133

[Perrimon Lab @PerrimonLab]

New paper: Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth in Drosophila. Huang K, Miao T, Chen Y, Dantas E, Sanford J, Asara JM, Moon SJ, Hu Y, Wang K, Han M, Goncalves M, Perrimon N. Nat Commun. 2026 Jul 3. doi: 10.1038 s41467-026-75074-w.

[Perrimon Lab @PerrimonLab]

New paper:
Streptomyces produce a diphtheria toxin-like exotoxin that targets insects.
Xu et al.Nat Microbiol. 2026 Apr 30. doi: 10.1038/s41564-026-02315-5. Online ahead of print. PMID: 42062574

[Perrimon Lab @PerrimonLab]

@kapahi_pankaj https://t.co/F4KlbNXbPm

[Perrimon Lab @PerrimonLab]

New paper: Bosch, J. A. et al. (2026) Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking. Nat Commun. doi: 10.1038/s41467-026-71763-8. PMID: 42009678

[Perrimon Lab @PerrimonLab]

Miao, T., Liu, Y., Qadiri, M., Dasseux, A., Asara, J. M., Hu, Y., Sun, X., Pliego-Alcántara, LDC., Dibble, C. and Perrimon, N. (2026) Renal coenzyme A (CoA) production from Vitamin B5 fuels stem cell proliferation and tumor growth. Nat Commun. doi: 10.1038/s41467-026-71716-1.

[Perrimon Lab @PerrimonLab]

https://t.co/0LaX6REOZT

[Perrimon Lab @PerrimonLab]

Han. M., Xia, B., Kim, A-R., Filine, E., Stoneburner, E., Miao, T., Liu, Y., Zirin, J. and Perrimon, N. (2026) Phage display-mediated immuno-PCR to detect low-abundance secreted proteins in Drosophila. PNAS. 14;123(15):e2531777123. doi: 10.1073/pnas.2531777123. PMID: 41941621

[Perrimon Lab @PerrimonLab]

Petsakou, A., Filine. E., Li, M., Zheng, A., and Perrimon, N. (2026) Tumor-induced orexigenic imbalance lowers protein appetite and drives early organ wasting symptoms. Nature Communications. doi: 10.1038/s41467-026-70074-2. PMID: 41792134