Friedel Lab

Our goal is to provide a better understanding of the molecular machinery that drives proliferation, invasiveness, and therapy resistance of brain tumor cells.

[Friedel Lab @LabFriedel]

Way to go! 👉 Congrats Jiaxi and #Zoulab team for new study on control of #Schwann cell mediated #nerve repair via #Plexin-B1 🥳
Out now at: https://t.co/Cq3oAn8hyO
@SinaiBrain @MountSinaiNeuro

[Friedman Brain Institute @SinaiBrain]

In @swagata_dey's "The Garden of Forgetfulness", Aβ plaques bloom like toxic flowers in neural landscape of an #Alzheimers brain while a thicket of glial cells attempts to contain the "overgrowth" in biological valley where memory begins to fade. #ArtoftheBrain #14👉Most🧡s wins!

[ISMMSscopes @ISMMSscopes]

@IcahnMountSinai Sign up for Image Analysis Workshop 🔬

Imaging basics & sample prep
Fiji & QuPath analysis
AI tools + beginner Python
Segmentation workflows
🎯 Optimize acquisition, run analysis & know when to use AI or scripting
#microscopy #imageanalysis

[Friedel Lab @LabFriedel]

Congratulations 🥳🥳🥳Dalia, Yiqun, and #Zoulab for pioneering study on control of nerve and #spinalcordinjury repair by transcription factor AhR
Out today at:
https://t.co/lPtqaVWJ57
@SinaiBrain @MountSinaiNeuro

[Joseph A. Sparano, MD @jsparano]

Please support this effort to create and fund the Empire Biomedical Research Institute (EBRI) by signing this petition. If funded, EBRI will support investigator-initiated biomedical research, training, and shared infrastructure in NY state.
https://t.co/9OFS38lh78

[Friedel Lab @LabFriedel]

Our Assistant Professor Dalia Halawani is moving to University of Cologne, after a very productive time on #SCI spinal cord injury research. All the best for your future! Alles Gute! You will be greatly missed!
#Zoulab @SinaiBrain

[Friedel Lab @LabFriedel]

Aloha for #SNO2025 from #Zoulab @LabFriedel 🌴

[Friedel Lab @LabFriedel]

Congratulations @HAOFEINI for a trailblazing study on astrocyte function in spinal cord injury repair! Right after your #SfN2025 poster! 不错 👍🥳
https://t.co/aKFUIaU9yd
@SinaiBrain @MountSinaiNeuro

[Friedel Lab @LabFriedel]

Please join us tomorrow 12 PM for an exciting talk by Dr. Lowenstein on new principles of brain invasion by tumor cells @TischCancer @SinaiBrain

[Mount Sinai Tisch Cancer Center @TischCancer]

We look forward to hearing from Shwetal Mehta, PhD on #Glioblastoma drug development on Oct. 28.
https://t.co/lOihL6s9Fr
@smehtalab @BarrowNeuro
Hosted by Roland Friedel, PhD, @IcahnMountSinai

[Friedman Brain Institute @SinaiBrain]

✨Congratulations to Drs. @SirChrystian & @neurodasilva for receiving the 2025 Nash Family Research Scholar Award for "Mechano-Electrical Regulation of Neurogenesis". Here, Drs. Chrystian Junqueira Alves & Daniel da Silva discuss their work👉https://t.co/3WQYWcxBCO

[Friedman Brain Institute @SinaiBrain]

#MSNseminars APPLICATION DEADLINE EXTENDED➡️Sept 14th! Senior postdocs (at U.S.-based institutes) in all fields of #Neuroscience encouraged to apply. INCREDIBLE OPPORTUNITY to share your research, visit Mount Sinai & meet w/ faculty/trainees!👉Scan QR code on poster to APPLY NOW!

[Friedman Brain Institute @SinaiBrain]

#MSNseminars APPLICATIONS DEADLINE➡️THIS FRIDAY! Senior postdocs (at U.S.-based institutes) in all fields of #Neuroscience encouraged to apply. INCREDIBLE OPPORTUNITY to share your research, visit Mount Sinai & meet w/ faculty/trainees! APPLY NOW👉Scan QR code on poster to apply!

[Costas Hadjipanayis @hadjiMDPhD]

Excited to introduce the new open access Journal of Neuro-Oncology Discovery which will provide another platform for basic, translational, clinical, and interdisciplinary research in neuro-oncology. A big thank you to @jasonpsheehan and @SpringerNature!
https://t.co/g0lh0kYDqS

[Friedel Lab @LabFriedel]

On a break at the first @cshlmeetings
Brain Tumor meeting 🧠 #cshlbtumor 2025 Thank you to the organizers for putting together this exciting event!
@HambardzumyanL1 @RRead_Lab #zoulab

[Friedel Lab @LabFriedel]

Congrats @HAOFEINI for this important work to open up the cell type specific exploration of #Plexin B1 in mice ! 恭喜恭喜!
https://t.co/i9A35NcxI2

More papers to come on this topic soon, stay tuned 🦠🔬 @SinaiBrain @MountSinaiNeuro

[Friedel Lab @LabFriedel]

Congrats 🥳Vivian and Guohao to developing this highly relevant new vascularized 3D #GBM model! Proud to be part of this exciting collaboration
@SinaiBrain @MountSinaiNeuro @TischCancer
https://t.co/patSsjau6U

[Dr. Guohao Dai @guohaodai]

Excited to share our work in Advanced Science. We developed a brain vascular niche model that captures glioblastoma infiltration, dormancy, and gene signatures: https://t.co/dC5cPBbYGo, @endothelialnews @NUBioE1

[Friedel Lab @LabFriedel]

Congratulations @sangjokang.bsky.social and #zoulab for this pioneering study on how microglia shape invasion of brain cancer cells through cell collision mechanism with Plexin-B2. 축하해요 ! 🥳 https://t.co/als2dhWqk5
@SinaiBrain @MountSinaiNeuro @TischCancer

[Jun Kim @Jun_kiim]

Published in @NatureCancer (May 2025), Kang et al. uncover a novel microglia-driven mechanism governing GBM transition from bulk tumor growth to invasive spread.

They reveal that microglia, guided by the protein plexin-B2, undergo a remarkable transformation—initially forming protective “glial nets” around small tumor infiltrates, and subsequently reorganizing into structured pathways called “oncostreams” that actively facilitate collective tumor cell migration. Plexin-B2 is central to this invasive process, orchestrating tumor cell alignment, resolves cell collisions, and remodels the ECM into organized tracks for GBM invasion.

This study provides critical new insights into GBM’s complex TME, positioning microglia as critical architects of tumor invasiveness—opening potential new therapeutic strategies that target stromal interactions to limit GBM progression.

@MountSinaiNeuro @IcahnMountSinai @SinaiBrain

[Friedel Lab @LabFriedel]

Congrats Sita for your Master thesis defense today in the #Zoulab ! Exciting studies on the role of #plexin in #glioblastoma invasion
Well done !!!🙌😀 @LabFriedel @SinaiBrain @MountSinaiNeuro @GradSchoolSinai