RewitzLab

We use the model insect Drosophila melanogaster to study totes dope hormonal regulation of growth & development, as well as models of neuropsychatric disorders.

[RewitzLab @LabRewitz]

This study was supported by @lundbeckfonden, @novonordiskfond, and @Carlsbergfondet — we are grateful for their support. 🙏

[RewitzLab @LabRewitz]

Why do we feel sleepy when sick, and how does gut health affect sleep? 🤒💤
Our new eLife study shows that gut inflammation signals to the brain to trigger sleep.
👉 https://t.co/eQhNEKrKR7
#Neuroscience #SleepResearch #GutBrainAxis

[RewitzLab @LabRewitz]

New from our lab in eLife! 🧠
We uncover how gut inflammation signals to the brain through glial JAK–STAT signaling, revealing a cytokine pathway that links intestinal health to sleep.
👉 https://t.co/eQhNEKrKR7

[ScienceNews @sciencenewsdk]

Researchers have discovered a cell surface receptor that is essential for adipose #tissue responding properly to #insulin. When the receptor is inactivated, the response to insulin is insufficient. However, a researcher says that it may be possible to stimulate the receptor – thereby protecting against the #development of type 2 #diabetes.

#sciencenewsdk

https://t.co/1mjD2aW0YI

[RewitzLab @LabRewitz]

We are thrilled to share that @eLife has now published our "reviewed preprint" on how signaling from the gut to glia connects intestinal inflammation to sleep in #Drosophila!
https://t.co/QYq6qR3EF3
@HalbergLab @Colombani_lab @lundbeckfonden @novonordiskfond @Carlsbergfondet

[RewitzLab @LabRewitz]

We are excited to share our recent work on gut-to-glia communication linking intestinal inflammation with sleep in #Drosophila! Many thanks to @HalbergLab and Andersen and @Colombani_lab!

@lundbeckfonden @novonordiskfond @Carlsbergfondet @UCPH_Research

https://t.co/ajFQmLhaQP

[RewitzLab @LabRewitz]

Thrilled to share our work! Thanks to @NovoNordiskFond and @DFF_raad, we unveil how LGR signaling mediates crosstalk between muscle, neuronal, and adipose tissues, protecting against #insulinresistance and offering insights into #Diabetes and #Obesity.

https://t.co/WvIv3S7avo

[RewitzLab @LabRewitz]

We are excited to share our recent work on gut-to-glia communication linking intestinal inflammation with sleep in #Drosophila! Many thanks to @HalbergLab and Andersen and @Colombani_lab!

@lundbeckfonden @novonordiskfond @Carlsbergfondet @UCPH_Research

https://t.co/ajFQmLhaQP

[HalbergLab @HalbergLab]

Latest from the lab: What are the mechanism by which insects maintain systemic ion and water balance as they interact with their environment? Another great collaboration with @DenholmLab!https://t.co/bVj6fcXXEp

[Nature Metabolism @NatMetabolism]

Online now! Glycolysis-derived alanine from glia fuels neuronal mitochondria for memory in Drosophila https://t.co/YR5uqoMC59

[Meet Zandawala @zandawala]

Let's try this again - look's like twitter can't handle the video 😂. Really excited to share the lab's first Drosophila paper and it's a big one. Check out our preprint https://t.co/Z1oI59uICG where we present the complete neural connectome of an animal circadian clock

[Perrimon Lab @PerrimonLab]

New paper: Petsakou, A., Liu, Y., Liu, Y. Comjean, A., Hu, Y. and Perrimon, N. Cholinergic neurons trigger epithelial Ca2+ currents to heal the gut. Nature (2023). https://t.co/ViGwrU0bHA

[Perrimon Lab @PerrimonLab]

Michael Ashburner (1942-2023).
Rubin GM. Curr Biol. 2023 Aug 18:S0960-9822(23)01072-2. doi: 10.1016/j.cub.2023.08.029.

[RewitzLab @LabRewitz]

Our preprint on #Obesity-driven #InsulinResistance reveals a muscle-neuronal-fat axis adapting to high-sugar-induced obesity conditions by influencing insulin secretion & sensitivity in #Drosophila. @Halberglab https://t.co/gPP2j0aQDd

[J. Colombani & D.S. Andersen lab @Colombani_lab]

Our last review:
Drosophila TNF/TNFRs: At the crossroad between metabolism, immunity, and tissue homeostasis
J. Colombani & D.S. Andersen - FEBS Letters - Wiley Online Library https://t.co/hG3lF8YxGA

[HalbergLab @HalbergLab]

Curious about how some beetles have evolved to drink, not with their mouths, but with their rectum? Check out our latest Quick Guide in the current issue of @CurrentBiology. In collaboration with @RobinBeaven @DenholmLab https://t.co/F1rx2g0t6Q

[HietakangasLab @HietakangasLab]

If you are interested in how genes are regulated in response to dietary sugar, please check out our recent publication 'Sugar-responsive inhibition of Myc-dependent ribosome biogenesis by Clockwork orange': https://t.co/m8oMCMcAEs 1/

[Meet Zandawala @zandawala]

Fresh preprint! Collaborative work with Chris Wegener's lab looking at the release of clock neuropeptide pigment dispersing factor.

[HalbergLab @HalbergLab]

How do animals weigh competing needs to maintain nutrient and fluid balance? Check out our recent review in #BioEssays in which we aim to provide a framework for understanding the polymodal optimization of homeostasis in insects. Also, pretty pictures... https://t.co/Zjesoew8kg

[J. Colombani & D.S. Andersen lab @Colombani_lab]

Thanks @crisprflydesign!
Nice #CRISPR clones showing that the TNF Receptor wgn plays an important role in lipid metabolism in the #Drosophila intestine.

https://t.co/Un5CkvhDbP

[Perrimon Lab @PerrimonLab]

New paper: split-intein Gal4 provides intersectional genetic labeling that is repressible by Gal80.
Ewen-Campen, Luan, Xu, Singh, Joshi, Thakkar, Berger, White, Perrimon. PNAS. 2023 doi: 10.1073/pnas.2304730120. Epub 2023 Jun 5. PMID: 37276389