RubinsteinLab

We are located in @TelAvivUni. We study the neuronal and molecular basis for severe epilepsy and autism.

[RubinsteinLab @LabRubinstein]

📢 A novel gene therapy for #Dravet. https://t.co/b4xbqD4drr. Using Canine adenovirus-2 (CAV-2) we delivered the full SCN1A coding sequence into the hippocampus and thalamus of juvenile Dravet mice.

[RubinsteinLab @LabRubinstein]

@BoazStyr @inna_slutsky Congratulations 🎉!!

[RubinsteinLab @LabRubinstein]

@HaitinLab Congratulations!!🎉

[RubinsteinLab @LabRubinstein]

@HaitinLab @TAUMedFaculty @tasmc1 Congratulations!! 🍾🎊

[RubinsteinLab @LabRubinstein]

@HaitinLab @TAUMedFaculty @of_sagol @TelAvivUni Thanks ❤️

[RubinsteinLab @LabRubinstein]

Sleep and thermoregulation are usually coupled. In our new paper, we find that in a #Dravet syndrome 🐭 this coupling collapses, with sleep failing to induce cooling and warmth failing to promote sleep.
https://t.co/7PSnwwWL4S

⸻

[RubinsteinLab @LabRubinstein]

In collaboration with Else Tolner (LUMC) and Eric Kremer (CNRS),  and the amazing teamwork of  Georgii Krivoshein, Hala Majadly, @Anat_Mavashov, Shahak Ranen, Marina Brusel, @iriareyes, and Bernard Boucher 🤩

[RubinsteinLab @LabRubinstein]

This work is dedicated to the memory of Dr. @SajaFadila1, my first student, who led this research 💔

[RubinsteinLab @LabRubinstein]

Congratulation!! 🥳🥳🎈🎈

[HaitinLab @HaitinLab]

🚨It's finally out!🥂 | A few years after solving the structure of human cis-PT, we now tackle its dynamics in @NatureComms, revealing that a conserved interfacial loop serves as an allosteric hub, communicating with the active site to regulate catalysis. https://t.co/fZRY0UHjVg

[HaitinLab @HaitinLab]

🚨It's finally out!🥂 | A few years after solving the structure of human cis-PT, we now tackle its dynamics in @NatureComms, revealing that a conserved interfacial loop serves as an allosteric hub, communicating with the active site to regulate catalysis. https://t.co/fZRY0UHjVg

[RubinsteinLab @LabRubinstein]

@HaitinLab @FEBSJournal @peterslab1 @TAUMedFaculty Congratulations 🎈🎉!! 🍾

[HaitinLab @HaitinLab]

Excited to share our new paper in @FEBSJournal! 🎉
We show how a #MYELOMA-linked GGPPS mutation tweaks hexamerization, substrate binding and product inhibition, revealing an unexpected layer of protein prenylation regulation
🔗 https://t.co/c34uIT8YzQ
@peterslab1 @TAUMedFaculty

[RubinsteinLab @LabRubinstein]

Congratulations!! 🥳🥳

[HaitinLab @HaitinLab]

How does a cytoplasmic enzyme make a membrane product? 🤔🧬

We found that a hydrophobic residue cluster helps the human cis-prenyltransferase feed its product into the ER membrane!

MD simulations + fluorescence = mechanistic insight 👇
🔗https://t.co/NEPH55odQ1

[Igor Ulitsky @IgorUlitsky]

Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share:
"Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression".
A 🧵https://t.co/935AvtPL8S

[RubinsteinLab @LabRubinstein]

@HaitinLab @peterslab1 @AlbGiacomello @TAUMedFaculty @of_sagol Congratulations !!🍾💃🪩 an exciting global collaboration 🌍

[RubinsteinLab @LabRubinstein]

@TAUMedFaculty https://t.co/3tqf72nb6S

[RubinsteinLab @LabRubinstein]

Excited to share our paper! #GRIN2D-DEE 🐭model mirrors patient symptoms, from behavioral deficits and pathological brain activity to synaptic changes🔗 https://t.co/BmUwv1KUy7
An incredible collaboration with a GRIN2D family, @KarenAvraham, researchers & clinicians.

[RubinsteinLab @LabRubinstein]

An outstanding group of devoted students - Mor Yam, Jolan Nassir, Danielle Galber, Shir Quinn, Roni Gal, Eden Peled, Mor Ovadia, Mor Bordeynik Cohen; Wayne Frankel, Christopher Makinson, Moran Hausman-Kedem, Aviva Fattal-Valevski. @TAUMedFaculty

[RubinsteinLab @LabRubinstein]

https://t.co/3tqf72nb6S

[RubinsteinLab @LabRubinstein]

@Eyal_Roz @NYASciences Congratulations!!🍾

[RubinsteinLab @LabRubinstein]

led by the amazing @Anat_Mavashov

[RubinsteinLab @LabRubinstein]

Excited to share our upgraded #CHD2 mouse model! 🐭🧠 It better mimics the disorder, revealing key symptoms like motor deficits, autistic features & altered brain function⚡️
An amazing collaboration with @IgorUlitsky, supported by @curechd2.
🔗 Read more: https://t.co/UnCe5uaxab