Signoretti Lab

[Signoretti Lab @LabSignoretti]

We are looking for a JUNIOR PATHOLOGIST (at least 1 year of residency training) to join our group and lead one of our translational efforts in kidney cancer. Please contact us if you are interested and willing to spend at least 2 years in the lab.

[GU Oncology Now @GUOncologyNow]

⭐ We spoke with Sabina Signoretti, MD, of @harvardmed, on her team’s analysis of the phase 2 HCRN GU16-260 trial examining biomarkers of response to frontline nivolumab in metastatic clear-cell #RCC: https://t.co/dfB9ZKfgYs
🔎 The study drew on multiplex immunofluorescence and spatial profiling of the tumor microenvironment, and identified immune cell populations associated with favorable and unfavorable outcomes.

[Signoretti Lab @LabSignoretti]

Many congratulations Berkay Simsek for being a recipient of the KCRS 2025 Merit Awards for Translational Research @simsek_berkay_ @kidneycan @MassGenBrigham #KCRS25 #kidneycancer

[Toni Choueiri, MD @DrChoueiri]

The #KCRS2025 ⁦@kidneycan⁩ is also about ART!

[KidneyCAN @kidneycan]

#KCRS25 Oral Abstract: @simsek_berkay_ @BrighamWomens links CD163+ macrophages in RCC tumors to better outcomes with nivolumab. A potential new target for immunotherapy.

Read all the abstracts: https://t.co/Vjemnyfdh7
Register: https://t.co/wOSjrfnhZ2

#AcceleratingCures

[Michelle_Hirsch (Donovan) @MichelleDunno17]

Pathologist representation at this year’s #KCRS25, one of my most important and favorite meetings each year. 🔬🩺🩻 #gupathology #workingtogethertofightRCC @PayalKapur5 @Unclassified1 @drmehrarohit @kidneycan @OncoAlert @urotoday

[Gabriel Roberti, MD @Gabriel_Pathol]

So proud to be part of this incredible research team! #KCRS25 #pathology #kidneycancer @kidneycan

[Signoretti Lab @LabSignoretti]

We are looking for a JUNIOR PATHOLOGIST (at least 1 year of residency training) to join our group and lead one of our translational efforts in kidney cancer. Please contact us if you are interested and willing to spend at least 2 years in the lab.

[Chuck Stravin @CJSTRAV3]

Thanks to our friends at Cure Today for letting me share some advice for new patients. 👊👊 ⁦@DanaFarber⁩ ⁦@DrChoueiri⁩ ⁦@DanaFarber_GU⁩ ⁦@kidneycan⁩ ⁦@TheJimmyFund⁩ ⁦@DanaFarberNews⁩ https://t.co/MN90HwjuFr

[Toni Choueiri, MD @DrChoueiri]

Celebrating Dr Sabina Signoretti @BrighamWomens work and dedication over the years to @DanaFarber @BrighamWomens @df_hcc Pathology!

cc: @LabSignoretti @kaelin_lab @harvardmed

[Tom Powles @tompowles1]

Phase 1/2 Design of the HIF2a inhibitor NKT2152-101 showed response rate of 20% with an ‘in class’ toxicity profile #ESMO24 . The long half like makes it distinct and there in now a dose to take to randomised trials. Advantages over belzurifan are unclear. 2 doses being pursued.

[Neeraj Agarwal, MD, FASCO @neerajaiims]

Sarcomatoid RCC #kidneycancer : Diagnostic Updates and Therapeutic Implications. Comprehensive talk by @SabinaSign16728 @BrighamWomens 👉epigenomics, genetics and inflammed phenotype of Sarcomatoid RCC & Rx implications #KCRS24 @kidneycan @DrChoueiri @TalalZarif1 @OncoAlert

[Renee Maria Saliby @ReneeSaliby]

Kicking off the Trials in Progress session with #ARCITECT evaluating Botensilimab+Balstilimab for pts with mRCC

A trial that aims to "raise the tail" and a fantastic presentation by @MikeSerzanMD

#KCRS24 @kidneycan @OncoAlert

[KidneyCAN @kidneycan]

Great work from these presenters!

[Marc Machaalani, MD @MarcMachaalani]

The #INTerpath-004 trial explores the combination of pembro + personalized mRNA #vaccine for the adjuvant treatment of pts with RCC. Inspiring talk by @DrChoueiri at #KCRS24!

@kidneycan @DanaFarber_GU @OncLive

[Yüksel Ürün @DrYukselUrun]

🟢 Outstanding presentation at #KCRS24 @drmehrarohit
🟠 Role of Pathologist in Kidney Cancer Diagnostics and Research
🟠 Highlighting the morphologic diversity in renal tumors and its diagnostic implications.
🟠 Emphasis on understanding mechanisms to improve patient care.
@KidneyCancer @DrChoueiri @yekeduz_emre @neerajaiims @montypal @NazliDizman @advocatekidneys @HHammersMD @rovingatuscap @BraunMDPhD @DrRanaMcKay @FabioSchutz78 @AlbigesL @OncoAlert #cancer #oncology #KidneyCancer #KCRS24

[Tian Zhang, MD, MHS, FASCO (@tiansterzhangmd.bsky) @TiansterZhang]

We are super interested in the IVC thrombus @UTSWUrology @utswcancer @UTSWHemeOnc! @PayalKapur5 shows IVC correlates and Angioscore for as a biomarker for angiogenic driven tumor. @KCPUTSW #KCRS24 @kidneycan

[Yüksel Ürün @DrYukselUrun]

Thank you Chuck for sharing!
It’s very inspiring!
Advocacy, research, and patient care unite to accelerate the cure! We can’t do it alone – we need each other! @kidneycan @DrChoueiri @advocatekidneys #KCRS24 @OncoAlert @CJSTRAV3 #Advocate @HHammersMD @neerajaiims @yekeduz_emre @montypal @NazliDizman

[Sumanta K. Pal, MD, FASCO @montypal]

Brilliant insights from @tompowles1 @QMBCI. Excellent use of Twitter polls to reconcile tough clinical scenarios (eg IO rechallenge following adj pembro). Shocking to hear rates of IO receipt in real world series - great point from Tom - use the best tx first. @DrChoueiri @brian_rini @Uromigos @AlbigesL #KCRS24

Side note: was running late to the mtg today and used the virtual option to watch Tom’s talk. Thanks to @kidneycan for making it so easy to access!

[KidneyCAN @kidneycan]

#KCRS24 Session 8: Rapid Abstract Presentations are underway!

Tertiary Lymphoid Structures in Sarcomatoid RCC @NickSalgia
Brain-Specific Tropism in mRCC @rmelias2
Latino Ethnicity & Gut Microbiome in mRCC @ReginaBarCar

#KidneyCancer #AcceleratingCures