Spiegelman Lab

We study metabolic pathways regulating energy homeostasis, mitochondrial biogenesis, and muscle/adipose biology @DanaFarber @HarvardCellBio

[Spiegelman Lab @LabSpiegelman]

When we discovered irisin in 2012 (Bostrom et al), we described its actions in terms of the browning of the white fat and anti-diabetic effects. Here, in collaboration with the Mathis lab, we re-examine this in mechanistic detail. https://t.co/qDVrwgiGuM

[Spiegelman Lab @LabSpiegelman]

Another great annual retreat goes in the books. Our rule is you cant talk about what you work on, and it was so interesting. Props to the lab techs who each gave a great talk. Rockport is so lovely in the spring!

[Nature Metabolism @NatMetabolism]

The exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis https://t.co/bJjswWWSuk

[Spiegelman Lab @LabSpiegelman]

@LabSaltiel Definitely high standards on the AI-enhanced picture of you.

[Spiegelman Lab @LabSpiegelman]

It is interesting to note, that much of the effects of irisin can be ascribed to the subsequent production of IL-33 by stromal cells within the adipose tissues. We never imagined such a mechanism in 2012! Big congrats to Mu and Gang for these determined efforts.

[Spiegelman Lab @LabSpiegelman]

Lab alums Hage Sprenger and Louisa Grauvogel cut loose at Karneval in Köln!!

[Spiegelman Lab @LabSpiegelman]

@BarteltLab Oh, I love me some Boney M!!

[Spiegelman Lab @LabSpiegelman]

@LabSaltiel That's a beautiful piece Al. The invention of affinity chromatography was and remains a fundamental tool in biochemistry and molecular biology! RIP to a very important scientist.

[Spiegelman Lab @LabSpiegelman]

@LabSaltiel Who invented that picture of you looking so young?

[Spiegelman Lab @LabSpiegelman]

Last day of fishing is such a bittersweet day!

[Spiegelman Lab @LabSpiegelman]

Beware of scary scientists on Halloween!

[Sumeet Khetarpal @SumeetKhetarpal]

Here is @Rongtian2's News & Views article: https://t.co/GgJkymqTkT
@LabSpiegelman @rosenzweig_a

[Spiegelman Lab @LabSpiegelman]

Cardiac PGC1a is required for adaptations of the heart to exercise (in mice). A wonderful collaboration with the lab of Tony Rosenzweig. Sumeet is off to start his won lab at UVa (congrats!) https://t.co/gR7B2QuLIt

[Spiegelman Lab @LabSpiegelman]

@ManagerTactical Dude, I enjoy your channel but your hatred of MLS is boring 🥱 were you outraged when players were called up from Belgian or non-big 3 Dutch teams?

[Spiegelman Lab @LabSpiegelman]

Davo was a fantastic cook. This is after our last fishing adventure is June 2025

[Spiegelman Lab @LabSpiegelman]

The passing Of Dave Mangelsdorf is a terrible loss for his family, friends and the science world. Davo will never be forgotten. 😢 https://t.co/JQzVDG9RWS

[Spiegelman Lab @LabSpiegelman]

@CharlieDavies9 @clint_dempsey I'm also an adopted CC-er. Born in NY, faculty in Longwood area at a place you know very well. Boat in Dennis, house in Brewster. Where you at? DM here if you wanna

[Spiegelman Lab @LabSpiegelman]

It's not true that Jared Rutter can only do metabolite signaling! @CapeCod Bay