Saltiel lab

[Haipeng Fu @Haipeng_Fu]

Thrilled to share that I’ve been awarded an NIH K99/R00 Pathway to Independence Award from NIDDK!

I’m incredibly grateful to my mentor, @LabSaltiel, for his unwavering guidance & support. Excited to continue exploring mitochondrial biology in adipose tissue and metabolic health.

[David Morales-Álamo @D_Morales_Alamo]

New @Nature research article: dietary cholesterol not only raises LDL—it activates RAS→Ral signaling, driving LDLR internalization and CTSA-mediated lysosomal degradation, independent of PCSK9. Blocking CTSA restores LDLR and cuts circulating LDL in mice. https://t.co/YINx7WDq3f

[Saltiel lab @LabSaltiel]

Still a lot to learn about the Ral G proteins.

[nature @Nature]

Nature research paper: Dietary cholesterol activates a Ral-dependent pathway driving LDLR turnover

https://t.co/1ixjOCNGM4

[Saltiel lab @LabSaltiel]

How long-term dietary cholesterol can slow down its own clearance by liver cells https://t.co/wIBCXqi99H
Thanks to Dan Rader for the nice comments about our paper.

[Saltiel lab @LabSaltiel]

Investigational Drug Could Control Cholesterol https://t.co/VPcjuUDDnf
latest from star postdoc Xue Feng. Our continuing effort to explore the biology of Ral proteins.

[Saltiel lab @LabSaltiel]

really nice work. Glycogen plays an important regulatory role in many cells.

[Nature Metabolism @NatMetabolism]

Neuronal glycogen powers anticipatory brain responses to food https://t.co/wtC9gT8Q6Y

[JCI insight @JCI_insight]

@LabSaltiel @UCSanDiego Behind the scenes with first author Churaibhon Wisessaowapak as she prepares Western Blot samples.

[JCI insight @JCI_insight]

How does caloric restriction reduce energy expenditure while preserving energy storage?

https://t.co/T8EZ3a18c2
Alan R. Saltiel @LabSaltiel & team @UCSanDiego show TBK1 acts as a brake on fat burning during fasting—and the combination of a TBK1 inhibitor and an AMPK activator reverses obesity and improves #MetabolicHealth in mice.

The figure: Combined TBK1 inhibition and AMPK activation improve metabolic health in obese mice.

[UMLifeSciences @UMLifeSciences]

Tomorrow (5/12), join us for the 2026 Saltiel Life Sciences Symposium: Decoding #GLP1s.

View the full schedule, including a poster session featuring U-M research:
https://t.co/hJvwBu02hy

[WashU Medicine Endocrinology @WashUMedEndo]

Dr. Irfan Lodhi and collaborators identified a pathway that regulates how the body breaks down fat during metabolic stress, including severe illness and cachexia, revealing insight into how stable fat stores are mobilized under stress conditions. https://t.co/uhCGEJUC4V

[Saltiel lab @LabSaltiel]

@LabSpiegelman are you commenting on my high school yearbook picture?

[Saltiel lab @LabSaltiel]

UC San Diego Professor Elected to American Academy of Arts https://t.co/h8DXpjUKYs
As several of my friends have commented, standards seem to have slipped.

[Saltiel lab @LabSaltiel]

will be great to get back to Ann Arbor for this meeting.

[UMLifeSciences @UMLifeSciences]

Join us May 12 for the 2026 Saltiel Life Sciences Syposium: Decoding GLP-1s!
This full-day event will explore the fundamental cellular mechanisms behind the new generation of hashtag#GLP1 therapeutics, as well as ongoing efforts to improve them.

Speakers include @AmberAlhadeff, @DanielJDrucker, @TimoMueller_IDO, Martin Myers, @tunepers , @seeleyrj and @thewilliamslab

[Saltiel lab @LabSaltiel]

Sad news. Such a sweet guy. Always positive and supportive, a serious scholar and terrific leader. He'll be missed.

[Daniel J Drucker @DanielJDrucker]

A gentleman and scholar, leader in #islet biology, Editor of @Diabetes_ADA Professor Gordon Weir @Harvard @AmDiabetesAssn @JoslinDiabetes https://t.co/z8K8sNinY6 March 27 2026

[Jeffrey Flier @jflier]

With great sadness I report the passing of my scientific mentor Jesse Roth at age 91. Jesse was a brilliant & innovative scientist who led the field of membrane receptor biology from NIH diabetes branch. A small part of that family tree is shown. May his memory be a blessing.

[Saltiel lab @LabSaltiel]

Kvelling again about a former trainee. Xiao-wei Chen in another major breakthrough in Nature. Beautiful paper.

[nature @Nature]

Nature research paper: CLCC1 governs ER bilayer equilibration to maintain lipid homeostasis

https://t.co/fXc3w9vTeP

[Saltiel lab @LabSaltiel]

Very proud of my former trainee Shannon Reilly @ShannonReilly5. An exciting new look at thermogenesis.

[Nature Metabolism @NatMetabolism]

Fatty acids promote uncoupled respiration via ATP/ADP carriers in white adipocytes https://t.co/PZfmm76JAW

[ASBMB @ASBMB]

Meet the sixteen ASBMB members who were recognized for exceptional service and scientific impact across research, education, mentorship, outreach and leadership!

https://t.co/dKacsT3oFD
#ASBMBMemberNews #Biochemistry #MolecularBiology #ASBMBFellows

[ASBMB @ASBMB]

Meet the 2026 ASBMB Fellows

Sixteen members were recognized for exceptional service and scientific impact across research, education, mentorship, outreach and leadership.

Join us in celebrating them at #ASBMB26!

➡️ Learn more about the 2026 fellows: https://t.co/dKacsT3oFD.

[Gaia Trincucci @Gaia_JExpMed]

Today’s 📰#JEMjc @JExpMed highlights the work of
@LabSaltiel @UCSDMedSchool @Nature reporting the role of neutrophil-derived IL-1β in preserving lipid stores during metabolic stress.

https://t.co/dv19Sp0yBb